Search Results - "Cika, Jaclyn"

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation by Mitrea, Diana M., Cika, Jaclyn A., Stanley, Christopher B., Nourse, Amanda, Onuchic, Paulo L., Banerjee, Priya R., Phillips, Aaron H., Park, Cheon-Gil, Deniz, Ashok A., Kriwacki, Richard W.

“…Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of the nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes…”
Get full text

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA by Mitrea, Diana M, Cika, Jaclyn A, Guy, Clifford S, Ban, David, Banerjee, Priya R, Stanley, Christopher B, Nourse, Amanda, Deniz, Ashok A, Kriwacki, Richard W

“…The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation of its components from the surrounding nucleoplasm. Here, we show that…”
Get full text

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles by Lee, Kyung-Ha, Zhang, Peipei, Kim, Hong Joo, Mitrea, Diana M., Sarkar, Mohona, Freibaum, Brian D., Cika, Jaclyn, Coughlin, Maura, Messing, James, Molliex, Amandine, Maxwell, Brian A., Kim, Nam Chul, Temirov, Jamshid, Moore, Jennifer, Kolaitis, Regina-Maria, Shaw, Timothy I., Bai, Bing, Peng, Junmin, Kriwacki, Richard W., Taylor, J. Paul

“…Expansion of a hexanucleotide repeat GGGGCC (G4C2) in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia…”
Get full text

Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA by Dayeh, Daniel M., Cika, Jaclyn, Moon, Youmi, Henderson, Steven, Di Grandi, Deanna, Fu, Yue, Muthusamy, Kathir, Palackal, Nisha, Ihnat, Peter M., Pyles, Erica A.

“…•Characterized thermally stressed mRNAs using a panel of chromatographic assays.•Implemented SEC-MALS to confirm transcripts reflect full-length sequence…”
Get full text

Yeast Display Enables Identification of Covalent Single-Domain Antibodies against Botulinum Neurotoxin Light Chain A by Alcala-Torano, Rafael, Islam, Mariha, Cika, Jaclyn, Lam, Kwok Ho, Jin, Rongsheng, Ichtchenko, Konstantin, Shoemaker, Charles B., Van Deventer, James A.

“…While covalent drug discovery is reemerging as an important route to small-molecule therapeutic leads, strategies for the discovery and engineering of…”
Get full text

Two Decades of IDPs; What have we Learned? by Kriwacki, Richard, Mitrea, Diana M., Follis, Ariele, Iconaru, Luigi, Cika, Jaclyn, Ban, David, Philllips, Aaron

Get full text

The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions by Cika, Jaclyn Alicia

“…Nucleoli are nuclear membrane-less organelles that are the sites for ribosome biogenesis and serve as sensors of cellular stress. Weak, multivalent…”
Get full text