Search Results - "Cihlar, Tomas"

Current status and prospects of HIV treatment by Cihlar, Tomas, Fordyce, Marshall

“…•With no available cure, treatment of HIV infection requires life-long therapy.•A combination of three drugs is the current standard for chronic HIV…”
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Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection by de Wit, Emmie, Feldmann, Friederike, Cronin, Jacqueline, Jordan, Robert, Okumura, Atsushi, Thomas, Tina, Scott, Dana, Cihlar, Tomas, Feldmann, Heinz

“…The continued emergence of Middle East Respiratory Syndrome (MERS) cases with a high case fatality rate stresses the need for the availability of effective…”
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV by Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections…”
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A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19 by Xie, Xuping, Muruato, Antonio E., Zhang, Xianwen, Lokugamage, Kumari G., Fontes-Garfias, Camila R., Zou, Jing, Liu, Jianying, Ren, Ping, Balakrishnan, Mini, Cihlar, Tomas, Tseng, Chien-Te K., Makino, Shinji, Menachery, Vineet D., Bilello, John P., Shi, Pei-Yong

“…A high-throughput platform would greatly facilitate coronavirus disease 2019 (COVID-19) serological testing and antiviral screening. Here we present a…”
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Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets by Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.

“…Remdesivir is an antiviral approved for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may…”
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Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy by Tsai, Angela, Irrinki, Alivelu, Kaur, Jasmine, Cihlar, Tomas, Kukolj, George, Sloan, Derek D, Murry, Jeffrey P

“…Antiretroviral therapy can suppress HIV replication to undetectable levels but does not eliminate latent HIV, thus necessitating lifelong therapy. Recent…”
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses by Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S

“…Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the…”
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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease by Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

“…Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated…”
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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses by Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.

“…GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It…”
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Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid by Peng, Ke, Muranyi, Walter, Glass, Bärbel, Laketa, Vibor, Yant, Stephen R, Tsai, Luong, Cihlar, Tomas, Müller, Barbara, Kräusslich, Hans-Georg

“…The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined…”
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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses by Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

“…The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history with over 28,000 cases, resulting in >11,000 deaths including >500…”
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Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat by Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S

“…Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the…”
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TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy by Lim, So-Yon, Osuna, Christa E, Hraber, Peter T, Hesselgesser, Joe, Gerold, Jeffrey M, Barnes, Tiffany L, Sanisetty, Srisowmya, Seaman, Michael S, Lewis, Mark G, Geleziunas, Romas, Miller, Michael D, Cihlar, Tomas, Lee, William A, Hill, Alison L, Whitney, James B

“…Antiretroviral therapy (ART) can halt HIV-1 replication but fails to target the long-lived latent viral reservoir. Several pharmacological compounds have been…”
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Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing by Wei, Datsen George, Chiang, Vicki, Fyne, Elizabeth, Balakrishnan, Mini, Barnes, Tiffany, Graupe, Michael, Hesselgesser, Joseph, Irrinki, Alivelu, Murry, Jeffrey P, Stepan, George, Stray, Kirsten M, Tsai, Angela, Yu, Helen, Spindler, Jonathan, Kearney, Mary, Spina, Celsa A, McMahon, Deborah, Lalezari, Jacob, Sloan, Derek, Mellors, John, Geleziunas, Romas, Cihlar, Tomas

“…Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation…”
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PREVAIL IV: A Randomized, Double-Blind, 2-Phase, Phase 2 Trial of Remdesivir vs Placebo for Reduction of Ebola Virus RNA in the Semen of Male Survivors by Higgs, Elizabeth S, Gayedyu-Dennis, Dehkontee, Fischer II, William A, Nason, Martha, Reilly, Cavan, Beavogui, Abdoul Habib, Aboulhab, Jamila, Nordwall, Jacqueline, Lobbo, Princess, Wachekwa, Ian, Cao, Huyen, Cihlar, Tomas, Hensley, Lisa, Lane, H Clifford

“…Abstract Background Ebola virus RNA persists in the semen of male Ebola survivors for months to years after the acute infection, and male-to-female sexual…”
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Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice by Martinez, David R., Schäfer, Alexandra, Leist, Sarah R., Li, Dapeng, Gully, Kendra, Yount, Boyd, Feng, Joy Y., Bunyan, Elaine, Porter, Danielle P., Cihlar, Tomas, Montgomery, Stephanie A., Haynes, Barton F., Baric, Ralph S., Nussenzweig, Michel C., Sheahan, Timothy P.

“…Improving clinical care for individuals infected with SARS-CoV-2 variants is a global health priority. Small-molecule antivirals like remdesivir (RDV) and…”
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Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells by Balakrishnan, Mini, Yant, Stephen R, Tsai, Luong, O'Sullivan, Christopher, Bam, Rujuta A, Tsai, Angela, Niedziela-Majka, Anita, Stray, Kirsten M, Sakowicz, Roman, Cihlar, Tomas

“…HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site…”
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Author Correction: A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19 by Xie, Xuping, Muruato, Antonio E., Zhang, Xianwen, Lokugamage, Kumari G., Fontes-Garfias, Camila R., Zou, Jing, Liu, Jianying, Ren, Ping, Balakrishnan, Mini, Cihlar, Tomas, Tseng, Chien-Te K., Makino, Shinji, Menachery, Vineet D., Bilello, John P., Shi, Pei-Yong

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Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells by Sloan, Derek D, Lam, Chia-Ying Kao, Irrinki, Alivelu, Liu, Liqin, Tsai, Angela, Pace, Craig S, Kaur, Jasmine, Murry, Jeffrey P, Balakrishnan, Mini, Moore, Paul A, Johnson, Syd, Nordstrom, Jeffrey L, Cihlar, Tomas, Koenig, Scott

“…HIV reservoirs and production of viral antigens are not eliminated in chronically infected participants treated with combination antiretroviral therapy (cART)…”
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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy by Burdette, Dara L, Lazerwith, Scott, Yang, Jenny, Chan, Henry L Y, Delaney Iv, William E, Fletcher, Simon P, Cihlar, Tomas, Feierbach, Becket

“…Nucleos(t)ide analogs are standard-of-care for the treatment of chronic hepatitis B and can effectively reduce hepatitis B virus (HBV) replication but rarely…”
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