Controlled release of 5-aminosalicylicacid from chitosan based pH and temperature sensitive hydrogels

Controlled release of 5-aminosalicylicacid from chitosan based pH and temperature sensitive hydrogels

A series of temperature and pH responsive hydrogels based on chitosan and poly(N-isopropyl acrylamide) (PNIPA) was prepared by redox polymerization. Effect of the composition on swelling behavior of the hydrogels and the release of 5-aminosaylcilic acid (5-ASA) at different temperatures and pHs have...

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Bibliographic Details
Published in:International journal of biological macromolecules Vol. 52; pp. 177 - 183
Main Authors: Bostan, Muge Sennaroglu, Senol, Murat, Cig, Tugce, Peker, Ismail, Goren, Ahmet C., Ozturk, Turan, Eroglu, Mehmet S.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-01-2013
Subjects:
5-ASA
acrylamides
Acrylic Resins - chemistry
ambient temperature
calorimeters
Chitosan
Chitosan - chemistry
Delayed-Action Preparations - chemistry
Drug release
Epoxy Compounds - chemistry
fluorescence emission spectroscopy
gelatinization temperature
Hot Temperature
hydrocolloids
Hydrogel
Hydrogels - chemistry
Mesalamine - chemistry
Methacrylates - chemistry
NIPA
phase transition
polymerization
Drug release
NIPA
Chitosan
Hydrogel
5-ASA
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Summary:A series of temperature and pH responsive hydrogels based on chitosan and poly(N-isopropyl acrylamide) (PNIPA) was prepared by redox polymerization. Effect of the composition on swelling behavior of the hydrogels and the release of 5-aminosaylcilic acid (5-ASA) at different temperatures and pHs have been investigated. Ammonium persulphate and TEMED were used as a redox pair at room temperature. As a cross linker, methacrylated chitosan was synthesized through the reaction of chitosan with glycidyl methacrylate (GMA). Introduction of the cross-linker provided the hydrogels with pH and temperature sensitivities. The phase transition temperatures of the hydrogels were determined by derivative differential scanning calorimeter (DDSC). Their phase transition temperatures were increased by chitosan content. Swelling behaviors and the release of 5-ASA varied significantly with pH, temperature and the gel composition. The release of 5-ASA from the hydrogels was followed by UV–Vis and fluorescence spectroscopy.
Bibliography:http://dx.doi.org/10.1016/j.ijbiomac.2012.09.018
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ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2012.09.018