Search Results - "Cid, J"
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Prevention of transfusion‐associated graft‐versus‐host disease with pathogen‐reduced platelets with amotosalen and ultraviolet A light: a review
Published in Vox sanguinis (01-10-2017)“…Background and Objectives Transfusion‐associated graft‐versus‐host disease (TA‐GVHD) is a serious complication of blood component transfusion therapy, caused…”
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The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism
Published in PLoS pathogens (16-04-2020)“…Brucella species are facultative intracellular Gram-negative bacteria relevant to animal and human health. Their ability to establish an intracellular niche…”
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Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer
Published in The New England journal of medicine (22-11-2018)“…The addition of pembrolizumab, an anti–PD-1 antibody, to a platinum–taxane chemotherapy combination significantly prolonged progression-free and overall…”
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On the existence of periodic oscillations for pendulum-type equations
Published in Advances in nonlinear analysis (01-01-2021)“…We provide new sufficient conditions for the existence of -periodic solutions for the -laplacian pendulum equation ( ′))′ + ′ + sin = ), where ∈ . Our main…”
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A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
Published in Human molecular genetics (01-11-2011)“…The PTEN (phosphatase and tensin homolog) phosphatase is unique in mammals in terms of its tumor suppressor activity, exerted by dephosphorylation of the lipid…”
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Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent
Published in PLoS pathogens (19-03-2020)“…Klebsiella pneumoniae is recognized as an urgent threat to human health due to the increasing isolation of multidrug resistant strains. Hypervirulent strains…”
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A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Published in Nature communications (16-02-2023)“…Bacteria can inhibit the growth of other bacteria by injecting effectors using a type VI secretion system (T6SS). T6SS effectors can also be injected into…”
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Heterologous Expression and Auto-Activation of Human Pro-Inflammatory Caspase-1 in Saccharomyces cerevisiae and Comparison to Caspase-8
Published in Frontiers in immunology (14-07-2021)“…Caspases are a family of cysteine proteases that play an essential role in inflammation, apoptosis, cell death, and development. Here we delve into the effects…”
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Positivity and lower and upper solutions for fourth order boundary value problems
Published in Nonlinear analysis (01-09-2007)“…This paper is devoted to the study the boundary value problem { u ( 4 ) ( t ) = f ( t , u ( t ) ) for all t ∈ I = [ 0 , 1 ] , u ( 0 ) = u ( 1 ) = u ″ ( 0 ) =…”
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10
The full power of the half-power
Published in Expositiones mathematicae (01-12-2022)“…We use the complex square root to define a very simple homotopic invariant over the non-vanishing functions defined on the circle. As a consequence we provide…”
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A ring-theoretic approach to the double-sidedness of the matrix inverse
Published in Elemente der Mathematik (01-01-2024)“…We present an inductive proof of the double-sidedness of the matrix inverse based on a property that holds true for associative rings with unity…”
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12
Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
Published in Open biology (24-05-2023)“…Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the…”
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A modular route to boron doped PAHs by combining borylative cyclisation and electrophilic C-H borylation
Published in Chemical science (Cambridge) (2017)“…Heteroatom doping into polyaromatic hydrocarbons (PAHs) is a powerful approach for modifying key physical properties, however, there are extremely few modular…”
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14
A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity
Published in PloS one (15-04-2015)“…Spatial regulation of the tumor suppressor PTEN is exerted through alternative plasma membrane, cytoplasmic, and nuclear subcellular locations. The N-terminal…”
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Heterologous mammalian Akt disrupts plasma membrane homeostasis by taking over TORC2 signaling in Saccharomyces cerevisiae
Published in Scientific reports (16-05-2018)“…The Akt protein kinase is the main transducer of phosphatidylinositol-3,4,5- tris phosphate (PtdIns3,4,5P 3 ) signaling in higher eukaryotes, controlling cell…”
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Progress in the developement of positive allosteric modulators of the metabotropic glutamate receptor 2
Published in Current medicinal chemistry (2011)“…The metabotropic glutamate type 2 (mGlu2) receptor is a G-protein coupled receptor (GPCR) expressed on presynaptic nerve terminals where it negatively…”
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Oxidation of edible animal fats. Comparison of the performance of different quantification methods and of a proposed new semi-objective colour scale-based method
Published in Food chemistry (15-02-2017)“…•The performance of methods used for fat oxidation assessment was compared.•Samples of three types of animal fats with different oxidation level were…”
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Functional analysis of PTEN variants of unknown significance from PHTS patients unveils complex patterns of PTEN biological activity in disease
Published in European journal of human genetics : EJHG (01-05-2023)“…Heterozygous germline mutations in PTEN gene predispose to hamartomas and tumors in different tissues, as well as to neurodevelopmental disorders, and define…”
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The Salmonella effector SteA binds phosphatidylinositol 4‐phosphate for subcellular targeting within host cells
Published in Cellular microbiology (01-07-2016)“…Summary Many bacterial pathogens use specialized secretion systems to deliver virulence effector proteins into eukaryotic host cells. The function of these…”
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Randomized control trial to assess the efficacy of metacognitive training compared with a psycho-educational group in people with a recent-onset psychosis
Published in Psychological medicine (01-07-2017)“…Aims were to assess the efficacy of metacognitive training (MCT) in people with a recent onset of psychosis in terms of symptoms as a primary outcome and…”
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