Search Results - "Cicila, G T"

Spectrum of aerobic endurance running performance in eleven inbred strains of rats by Barbato, John C, Koch, Lauren Gerard, Darvish, Ahmad, Cicila, George T, Metting, Patricia J, Britton, Steven L

“…Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614-5804 The goal of this study was to identify inbred rat strains…”
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Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats by Cicila, G T, Rapp, J P, Bloch, K D, Kurtz, T W, Pravenec, M, Kren, V, Hong, C C, Quertermous, T, Ng, S C

“…To determine whether the endothelin-1 or endothelin-3 genes are genetically linked with blood pressure and relative heart weight in segregating rat…”
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Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats by Garrett, M R, Dene, H, Walder, R, Zhang, Q Y, Cicila, G T, Assadnia, S, Deng, A Y, Rapp, J P

“…An F2 population (n = 151) derived from Dahl salt-sensitive (S) and Lewis rats was raised on a 8% NaCl diet for 9 weeks and analyzed for blood pressure…”
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Cloned cDNA sequence for the human mesothelial protein mesosecrin discloses its identity as a plasminogen activator inhibitor (PAI-1) and a recent evolutionary change in transcript processing by CICILA, G. T, O'CONNELL, T. M, HAHN, W. C, RHEINWALD, J. G

“…Mesosecrin, a Mr approximately 46 x 10(3) glycoprotein secreted in abundance by human mesothelial cells in culture, was recently described by this laboratory…”
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Cultured myofibroblasts generate angiotensin peptides de novo by Katwa, L C, Campbell, S E, Tyagi, S C, Lee, S J, Cicila, G T, Weber, K T

“…Scar tissue found at the site of myocardial infarction (MI) contains phenotypically transformed fibroblast-like cells termed myofibroblasts (myoFb). In injured…”
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Functional genomics in rat models of hypertension: using differential expression and congenic strains to identify and evaluate candidate genes by Lee, Soon Jin, Cicila, George T

“…Hypertension is a leading contributor to cardiovascular diseases such as heart attack and stroke. Genetic and environmental factors contribute to the…”
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High-Resolution Mapping of the Blood Pressure QTL on Chromosome 7 Using Dahl Rat Congenic Strains by Cicila, George T, Garrett, Michael R, Lee, Soon Jin, Liu, Jun, Dene, Howard, Rapp, John P

“…It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat…”
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A Genome Scan for Loci Associated with Aerobic Running Capacity in Rats by Ways, Justin A, Cicila, George T, Garrett, Michael R, Koch, Lauren Gerard

“…Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA…”
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Linkage analysis of neointimal hyperplasia and vascular wall transformation after balloon angioplasty by Nestor, Andrea L, Cicila, George T, Karol, Seth E, Langenderfer, Kay M, Hollopeter, Stacy L, Allison, David C

“…1 Departments of Surgery, Pharmacology, Metabolism, and Cardiovascular Science, Medical University of Ohio, Toledo, Ohio 2 Physiology, Pharmacology,…”
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Estimate of the genetic divergence between inbred Dahl salt-sensitive and salt-resistant rats by Ginn, D I, Baptista, C A, Alam, K Y, Deng, A Y, Cicila, G T, Margolius, H S, Rapp, J P

“…The genetic divergence of inbred Dahl salt-sensitive (SS/Jr) rats from inbred Dahl salt-resistant (SR/Jr) rats and various other inbred strains was measured…”
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Gene expression profiling of the left ventricles in a rat model of intrinsic aerobic running capacity by Lee, Soon Jin, Ways, Justin A, Barbato, John C, Essig, David, Pettee, Krista, DeRaedt, Sarah J, Yang, Siming, Weaver, David A, Koch, Lauren G, Cicila, George T

“…1 Department of Physiology and Cardiovascular Genomics, Medical University of Ohio, Toledo; and 2 Department of Cell Biology, Lerner Research Institute,…”
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Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat by Cicila, George T, Rapp, John P, Wang, Jia-Ming, St. Lezin, Elizabeth, Chung Ng, Shi, Kurtz, Theodore W

“…In Dahl salt-hypertension sensitive (S) and resistant (R) strains fed a high NaCl diet, 11 beta-hydroxylase polymorphisms cosegregate with the adrenal capacity…”
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Valvular interstitial cells express angiotensinogen and cathepsin D, and generate angiotensin peptides by Katwa, Laxmansa C., Tyagi, Suresh C., Campbell, Scott E., Lee, Soon Jin, Cicila, George T., Weber, Karl T.

“…Cells capable of de novo angiotensin (Ang)II generation in the heart remain unidentified. High-density angiotensin converting enzyme (ACE) binding has been…”
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Two blood pressure/cardiac mass quantitative trait loci on Chromosome 3 in Dahl rats by Cicila, G T, Choi, C, Dene, H, Lee, S J, Rapp, J P

“…Interval mapping was used to identify putative quantitative trait loci (QTL) for blood pressure and cardiac mass on Chromosome (Chr) 3 in F₁(S × R) × S…”
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Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats by Cicila, G T, Dukhanina, O I, Kurtz, T W, Walder, R, Garrett, M R, Dene, H, Rapp, J P

“…11 beta-hydroxylase (Cyp11b1) mutations were previously linked to altered steroid biosynthesis and blood pressure in Dahl salt-resistant (R) and Dahl…”
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Regulation of the genes for 11β-hydroxysteroid dehydrogenase type 1 and type 2 in the kidney of the Dahl rat by Franco-Saenz, Roberto, Shen, Peijuan, Lee, Soon Jin, Cicila, George T, Henrich, W L

“…BACKGROUNDAn isoenzyme of 11β-hydroxysteroid dehydrogenase (11β-HSD), 11β-HSD-2 confers aldosterone specificity on the mineralocorticoid receptor (MR) and is…”
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Identifying Candidate Genes for Blood Pressure Quantitative Trait Loci Using Differential Gene Expression and a Panel of Congenic Strains by Cicila, George T., Lee, Soon Jin

“…The most difficult step in dissecting the molecular basis of a quantitative trait is proceeding from chromosomal locations associated with this trait (i.e.,…”
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improved linkage map of rat Chromosome 3 with three mapping panels by Dene, H, Choi, C R, Cicila, G T, Garrett, M R, Dukhanina, O I, Bihoreau, M T, Hoebee, B, Rapp, J P

“…Our purposes were to develop an improved linkage map for rat Chromosome 3 and to develop new markers polymorphic between Dahl salt-sensitive (S) and Dahl…”
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Regulation of the genes for 11beta-hydroxysteroid dehydrogenase type 1 and type 2 in the kidney of the Dahl rat by Franco-Saenz, R, Shen, P, Lee, S J, Cicila, G T, Henrich, W L

“…An isoenzyme of 11beta-hydroxysteroid dehydrogenase (11beta-HSD), 11beta-HSD-2 confers aldosterone specificity on the mineralocorticoid receptor (MR) and is…”
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Strategy for uncovering complex determinants of hypertension using animal models by Cicila, G T

“…Hypertension is a complex, multifactorial disorder resulting from the interaction of multiple genetic and environmental factors. While rodent models of…”
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