Search Results - "Ciccotosto, Giuseppe D."

The Alzheimer's Disease Amyloid Precursor Protein and its Neuritogenic Actions by Luu, Luan, Ciccotosto, Giuseppe D, Cappai, Roberto

“…The Amyloid Precursor Protein (APP) is principally known and studied for its involvement in Alzheimer's disease as the source of the amyloid β peptide;…”
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Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein by Tan, Jiang-Li, Li, Qiao-Xin, Ciccotosto, Giuseppe D, Crouch, Peter John, Culvenor, Janetta Gladys, White, Anthony Robert, Evin, Genevieve

“…BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid β (Aβ)…”
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Neurotoxicity of Prion Peptides on Cultured Cerebellar Neurons by Ciccotosto, Giuseppe D, Jana, Metta, Cappai, Roberto

“…Prion neurotoxicity has been modeled in vitro using synthetic peptides derived from the PrP sequence. The major region of neurotoxicity has been localized to…”
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Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease by Barnham, Kevin J, Kenche, Vijaya B, Ciccotosto, Giuseppe D, Smith, David P, Tew, Deborah J, Liu, Xiang, Perez, Keyla, Cranston, Greg A, Johanssen, Timothy J, Volitakis, Irene, Bush, Ashley I, Masters, Colin L, White, Anthony R, Smith, Jeffrey P, Cherny, Robert A, Cappai, Roberto

“…Amelyoid-β peptide (Aβ) is a major causative agent responsible for Alzheimer's disease (AD). Aβ contains a high affinity metal binding site that modulates…”
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Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina by Ho, Tracy, Vessey, Kirstan A, Cappai, Roberto, Dinet, Virginie, Mascarelli, Frédéric, Ciccotosto, Giuseppe D, Fletcher, Erica L

“…Amyloid precursor protein (APP) is a transmembrane glycoprotein frequently studied for its role in Alzheimer's disease. Our recent study in APP knockout (KO)…”
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Aggregation Distributions on Cells Determined by Photobleaching Image Correlation Spectroscopy by Ciccotosto, Giuseppe D, Kozer, Noga, Chow, Timothy T.Y, Chon, James W.M, Clayton, Andrew H.A

“…The organization of molecules into macromolecular (nanometer scale), supramolecular complexes (submicron-to-micron scale), and within subcellular domains, is…”
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MeCP2 interacts with chromosomal microRNAs in brain by Khan, Abdul Waheed, Ziemann, Mark, Rafehi, Haloom, Maxwell, Scott, Ciccotosto, Giuseppe D, El-Osta, Assam

“…Although methyl CpG binding domain protein-2 (MeCP2) is commonly understood to function as a silencing factor at methylated DNA sequences, recent studies also…”
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Polymyxins for CNS infections: Pharmacology and neurotoxicity by Velkov, Tony, Dai, Chongshan, Ciccotosto, Giuseppe D, Cappai, Roberto, Hoyer, Daniel, Li, Jian

“…Central nervous system (CNS) infections caused by multi-drug resistant (MDR) Gram-negative bacteria present a major health and economic burden worldwide. Due…”
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Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses by Abramov, Efrat, Dolev, Iftach, Fogel, Hilla, Ciccotosto, Giuseppe D, Ruff, Eyal, Slutsky, Inna

“…Even without the symptoms of Alzheimer's disease, normal brain releases a small amount of amyloid-β peptide (Aβ). Abramov and colleagues now show that…”
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Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis by Dai, Chongshan, Ciccotosto, Giuseppe D., Cappai, Roberto, Tang, Shusheng, Li, Daowen, Xie, Sanlei, Xiao, Xilong, Velkov, Tony

“…Neurotoxicity is an unwanted side-effect seen in patients receiving therapy with the “last-line” polymyxin antibiotics. This is the first study to show that…”
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Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue by Ciccotosto, Giuseppe D, James, Simon A, Altissimo, Matteo, Paterson, David, Vogt, Stefan, Lai, Barry, de Jonge, Martin D, Howard, Daryl L, Bush, Ashley I, Cappai, Roberto

“…The amyloid precursor protein (APP) gene family includes APP and the amyloid precursor-like proteins, APLP1 and APLP2. These proteins contain metal binding…”
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Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress by Dai, Chongshan, Ciccotosto, Giuseppe D, Cappai, Roberto, Wang, Yang, Tang, Shusheng, Xiao, Xilong, Velkov, Tony

“…Neurotoxicity is an adverse effect patients experience during colistin therapy. The development of effective neuroprotective agents that can be co-administered…”
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Bacterial Membrane Vesicles: The Missing Link Between Bacterial Infection and Alzheimer Disease by Butler, Catherine A, Ciccotosto, Giuseppe D, Rygh, Nathaniel, Bijlsma, Elly, Dashper, Stuart G, Brown, Angela C

“…Abstract Periodontitis is a common chronic inflammatory disease, affecting approximately 19% of the global adult population. A relationship between periodontal…”
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Trafficking of a Secretory Granule Membrane Protein Is Sensitive to Copper by De, Mithu, Ciccotosto, Giuseppe D., Mains, Richard E., Eipper, Betty A.

“…We explored the effect of copper availability on the synthesis and trafficking of peptidylglycine α-amidating monooxygenase (PAM), an essential cuproenzyme…”
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Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways by Dai, Chongshan, Ciccotosto, Giuseppe D, Cappai, Roberto, Wang, Yang, Tang, Shusheng, Hoyer, Daniel, Schneider, Elena K, Velkov, Tony, Xiao, Xilong

“…Our previous studies showed that colistin-induced neurotoxicity involves apoptosis and oxidative damage. The present study demonstrates a neuroprotective…”
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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export by Lei, Peng, Ayton, Scott, Finkelstein, David I, Spoerri, Loredana, Ciccotosto, Giuseppe D, Wright, David K, Wong, Bruce X W, Adlard, Paul A, Cherny, Robert A, Lam, Linh Q, Roberts, Blaine R, Volitakis, Irene, Egan, Gary F, McLean, Catriona A, Cappai, Roberto, Duce, James A, Bush, Ashley I

“…Tau aggregation is associated with neurodegenerative diseases called tauopathies. Ashley Bush and colleagues now report that aged tau-deficient mice develop…”
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Chronic Oral Inoculation of Porphyromonas gingivalis and Treponema denticola Induce Different Brain Pathologies in a Mouse Model of Alzheimer Disease by Ciccotosto, Giuseppe D, Mohammed, Ali I, Paolini, Rita, Bijlsma, Elly, Toulson, Su, Holden, James, Reynolds, Eric C, Dashper, Stuart G, Butler, Catherine A

“…Abstract Periodontitis is a chronic inflammatory disease driven by dysbiosis in subgingival microbial communities leading to increased abundance of a limited…”
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Membrane‐bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons by Jana, Metta K., Cappai, Roberto, Pham, Chi L. L., Ciccotosto, Giuseppe D.

“…Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques deposited in the brains of Alzheimer's disease patients and is central…”
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Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease by Duce, James A., Tsatsanis, Andrew, Cater, Michael A., James, Simon A., Robb, Elysia, Wikhe, Krutika, Leong, Su Ling, Perez, Keyla, Johanssen, Timothy, Greenough, Mark A., Cho, Hyun-Hee, Galatis, Denise, Moir, Robert D., Masters, Colin L., McLean, Catriona, Tanzi, Rudolph E., Cappai, Roberto, Barnham, Kevin J., Ciccotosto, Giuseppe D., Rogers, Jack T., Bush, Ashley I.

“…Alzheimer's Disease (AD) is complicated by pro-oxidant intraneuronal Fe 2+ elevation as well as extracellular Zn 2+ accumulation within amyloid plaque. We…”
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Fluorescence imaging of the interaction of amyloid beta 40 peptides with live cells and model membrane by Jamasbi, Elaheh, Hossain, Mohammed Akhter, Tan, Marsha, Separovic, Frances, Ciccotosto, Giuseppe D.

“…Amyloid beta peptides (Aβ) found in plaques in the brain have been widely recognised as a hallmark of Alzheimer's disease although the underlying mechanism is…”
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