The HLA-Cw06 allele and −1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

The HLA-Cw06 allele and −1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator...

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Bibliographic Details
Published in:Rheumatology international Vol. 33; no. 4; pp. 913 - 919
Main Authors: Cibulova, Anna, Zajacova, Marta, Fojtikova, Marketa, Stolfa, Jiri, Sedova, Liliana, Cejkova, Pavlina, Lippert, Jan, Arenberger, Petr, Cerna, Marie
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-04-2013
Springer Nature B.V
Subjects:
Adult
Alleles
Arthritis, Psoriatic - genetics
Arthritis, Psoriatic - immunology
Czech Republic
European Continental Ancestry Group - genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
HLA-C Antigens - genetics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Polymorphism, Single Nucleotide
Prolactin - genetics
Promoter Regions, Genetic
Psoriasis - genetics
Psoriasis - immunology
Rheumatology
Czech Republic
Psoriasis vulgaris
Prolactin
HLA-Cw
Age of psoriasis onset
Psoriatic arthritis
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Summary:Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to both diseases. We tested on an association of HLA-Cw alleles and functional polymorphism −1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw*06 allele and PsV ( P corrected  = 0.0013) that was most prominent in early onset disease subtype ( P corrected  = 0.0013). The association between HLA-Cw*06 and PsA was low ( P corrected  = 0.0585) and restricted to PsA patients with early PsV onset ( P corrected  = 0.0195). We found no association of −1149 G/T PRL gene polymorphism with either PsV or PsA.
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ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-012-2472-7