Search Results - "Ciavolella, Antonella"

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity by Ciavolella, Antonella, Rainoldi, Sonia, Isacchi, Antonella, Santocanale, Corrado, Tenca, Pierluigi, Montagnoli, Alessia, Valsasina, Barbara, Brotherton, Deborah, Croci, Valter, Cattoni, Marina, Patton, Veronica, Avanzi, Nilla, Alzani, Rachele, Tibolla, Marcello, Volpi, Daniele, Bensimon, Aaron, Albanese, Clara, Molinari, Antonio, Pesenti, Enrico, Healy, Sandra, Sola, Francesco, Moll, Jurgen, Vanotti, Ermes, Menichincheri, Maria, Marchesi, Vanessa, Fiorentini, Francesco, Ballinari, Dario

“…Cdc7 is an essential kinase that promotes DNA replication by activating origins of replication. Here, we characterized the potent Cdc7 inhibitor PHA-767491 ( 1…”
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Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors by Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

“…Polo-like kinase 1 (Plk1) is a fundamental regulator of mitotic progression whose overexpression is often associated with oncogenesis and therefore is…”
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Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding by Menichincheri, Maria, Albanese, Clara, Alli, Cristina, Ballinari, Dario, Bargiotti, Alberto, Caldarelli, Marina, Ciavolella, Antonella, Cirla, Alessandra, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, D’Anello, Matteo, Ermoli, Antonella, Fiorentini, Francesco, Forte, Barbara, Galvani, Arturo, Giordano, Patrizia, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Moll, Jürgen K, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Vianello, Paola, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53…”
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Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships by Vanotti, Ermes, Amici, Raffaella, Bargiotti, Alberto, Berthelsen, Jens, Bosotti, Roberta, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, D’Alessio, Roberto, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado

“…Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates that Cdc7 inhibition can cause selective…”
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Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships by Ermoli, Antonella, Bargiotti, Alberto, Brasca, Maria Gabriella, Ciavolella, Antonella, Colombo, Nicoletta, Fachin, Gabriele, Isacchi, Antonella, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Pillan, Antonio, Rainoldi, Sonia, Sirtori, Federico Riccardi, Sola, Francesco, Thieffine, Sandrine, Tibolla, Marcellino, Valsasina, Barbara, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 kinase has recently emerged as an attractive target for cancer therapy and low-molecular-weight inhibitors of Cdc7 kinase have been found to be effective…”
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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery by Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

“…Cdc7 kinase is a key regulator of the S-phase of the cell cycle, known to promote the activation of DNA replication origins in eukaryotic organisms. Cdc7…”
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Antitumor Efficacy of Edotecarin as a Single Agent and in Combination with Chemotherapy Agents in a Xenograft Model by CIOMEI, Marina, CROCI, Valter, CIAVOLELLA, Antonella, BALLINARI, Dario, PESENTI, Enrico

“…The novel indolocarbazole edotecarin (J-107088, formerly ED-749) differs from other topoisomerase I inhibitors both pharmacokinetically and…”
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Abstract 5805: A novel platform of diversified payloads to drive ADC innovation by Orsini, Paolo, Salsa, Matteo, Rizzi, Simona, Cucchi, Ulisse, Faiardi, Daniela, Burocchi, Alessia, Ciavolella, Antonella, Lupi, Rosita, Gasparri, Fabio, Valsasina, Barbara

“…Abstract First generation of antibody drug conjugates (ADCs) for anticancer therapy has been described more than two decades ago with gemtuzumab-ozogamicin…”
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NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies by Valsasina, Barbara, Beria, Italo, Alli, Cristina, Alzani, Rachele, Avanzi, Nilla, Ballinari, Dario, Cappella, Paolo, Caruso, Michele, Casolaro, Alessia, Ciavolella, Antonella, Cucchi, Ulisse, De Ponti, Anna, Felder, Eduard, Fiorentini, Francesco, Galvani, Arturo, Gianellini, Laura M, Giorgini, Maria L, Isacchi, Antonella, Lansen, Jaqueline, Pesenti, Enrico, Rizzi, Simona, Rocchetti, Maurizio, Sola, Francesco, Moll, Jürgen

“…Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase considered to be the master player of cell-cycle regulation during mitosis. It is indeed…”
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Abstract 509: The MPS1/TTK inhibitor, NMS-01940153, synergizes with tisotumab vedotin in colorectal cancer by Texido, Gemma, Gasparri, Fabio, Ciavolella, Antonella, Gianellini, Laura, Pedersen, Anders E., Ocaña, Alberto, Colombo, Riccardo, Roberti, Domenico, Mahnke, Lisa, Perrera, Claudia

“…Abstract Background: MPS1 kinase plays a crucial role in maintaining genomic integrity by controlling the spindle assembly checkpoint (SAC). MPS1 is highly…”
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Abstract 1223: NMS-P293, a novel potent and selective PARP-1 inhibitor with high antitumor efficacy and tolerability by Montagnoli, Alessia, Rainoldi, Sonia, Ciavolella, Antonella, Ballinari, Dario, Caprera, Francesco, Ceriani, Lucio, Lupi, Rosita, Ciomei, Marina, Felder, Eduard, Isacchi, Antonella, Donati, Daniele, Galvani, Arturo, Papeo, Gianluca

“…Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in oncology…”
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Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors by Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

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Abstract 1615: NMS-812, a novel potent PERK inhibitor that also inhibits GCN2, exhibits strong anti-tumor activity as single agent and in combination in preclinical models by Perrera, Claudia, Pulici, Maurizio, Banfi, Patrizia, Avanzi, Nilla, Carenzi, Davide, Casero, Daniele, Ciavolella, Antonella, Gianellini, Laura, Gasparri, Fabio, Saturno, Grazia, Valsasina, Barbara, Ardini, Elena, Montagnoli, Alessia, Galvani, Arturo P., Isacchi, Antonella

“…Abstract PERK and GCN2 are eIF-2α serine-threonine kinases activated by endoplasmic reticulum (ER) stress and amino acid deprivation respectively. These…”
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Cell-cycle inhibitor profiling by high-content analysis by Gasparri, Fabio, Ciavolella, Antonella, Galvani, Arturo

“…The discovery of agents which disrupt cancer cell division by specifically targeting key components of the cell-cycle machinery represents a major focus of…”
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Abstract 2851: Preclinical characterization of NMS-P648, a novel and potent PARP-1/-3 inhibitor by Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Cirla, Alessandra, Ciavolella, Antonella, Albanese, Clara, Modugno, Michele, Bosotti, Roberta, Somaschini, Alessio, Carapezza, Giovanni, Lupi, Rosita, Ballinari, Dario, Ciomei, Marina, Pesenti, Enrico, Donati, Daniele, Isacchi, Antonella, Galvani, Arturo

“…Abstract PARP-1 and PARP-2 are nuclear enzymes activated by DNA strand breaks and are involved in recruitment of DNA repair proteins to sites of damage. PARP-1…”
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Abstract 3259: Novel isoquinolinone derivatives with dual PARP-1/PARP-3 inhibitory activity are highly active against pTEN mutated colorectal cancer and glioblastoma models by Montagnoli, Alessia, Rainoldi, Sonia, Mazzoleni, Stefania, Ciavolella, Antonella, Lupi, Rosita, Casale, Elena, Ciomei, Marina, Pesenti, Enrico, Donati, Daniele, Galvani, Arturo, Papeo, Gianluca

“…Abstract Inhibitors of the poly(ADP-ribose) polymerases (PARPs) family of proteins are currently in clinical trials as potential anticancer agents. PARP-1 is a…”
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Abstract 1775: Characterization of new highly selective and potent PARP-1 inhibitors by Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Ciavolella, Antonella, Sola, Francesco, Lupi, Rosita, Ciomei, Marina, Cirla, Alessandra, Scolaro, Alessandra, Posteri, Helena, Donati, Daniele, Felder, Eduard, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo

“…Abstract Poly (ADP-ribose) polymerase 1 (PARP-1) is a key nuclear enzyme that is activated by DNA-strand breaks; activation of PARP-1 protects DNA breaks and…”
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9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds by Calogero, Francesco, Borrelli, Stella, Speciale, Gaetano, Christodoulou, Michael S., Cartelli, Daniele, Ballinari, Dario, Sola, Francesco, Albanese, Clara, Ciavolella, Antonella, Passarella, Daniele, Cappelletti, Graziella, Pieraccini, Stefano, Sironi, Maurizio

“…The introduction of a hydrophobic group at position 7 of 9‐fluorenone‐2‐carboxylic acid generates new tubulin binders, the design of which is suggested by…”
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Abstract DD01-01: NMS-1116354: More than an inhibitor of Cdc 7 kinase in S-phase by Colotta, Francesco, Moll, Jurgen, Valsasina, Barbara, Vanotti, Ermes, Rainoldi, Sonia, Sola, Francesco, Marchesi, Vanessa, Menichincheri, Maria, Ciavolella, Antonella, Patton, Veronica, Albanese, Clara, Volpi, Daniele, Avanzi, Nilla, Ballinari, Dario, Fiorentini, Francesco, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo, Santocanale, Corrado, Montagnoli, Alessia

“…Abstract Most of the widely used anticancer drugs target the elongation step of DNA synthesis, either directly, for example by restricting the pool of dNTPs or…”
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Abstract 691: In vitro and in vivo characterization of selective orally available Parp-1 inhibitors with demonstrated antitumor efficacy in BRCA negative cancer models by Papeo, Gianluca, Rainoldi, Sonia, Gianellini, Laura, Ciavolella, Antonella, Leone, Antonella, Lupi, Rosita, Sola, Francesco, Caprera, Francesco, Paolucci, Mauro, Thieffine, Sandrine, Perego, Rita, Albanese, Clara, Casale, Elena, Forte, Barbara, Guanci, Marco, Orsini, Paolo, Posteri, Helena, Scolaro, Alessandra, Riccardi-Sirtori, Federico, Zuccotto, Fabio, Donati, Daniele, Moll, Jurgen, Montagnoli, Alessia

“…Abstract Poly (ADP-ribose) polymerase 1 and 2 (Parp-1 and Parp-2) are nuclear enzymes responsible for signaling the presence of DNA damages by catalyzing the…”
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