Insulin-Like Growth Factor Binding Protein-3 Inhibits Colitis-Induced Carcinogenesis

PURPOSE: METHODS: RESULTS:A total of 20 mice (10 in each group) were included in the study. The severity of colitis was not significantly different between the two groups (mean colitis score wild-type = 13.2; IFGB-3 transgenic = 11; P = not significant). The average number of aberrant crypt foci per...

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Bibliographic Details
Published in:	Diseases of the colon & rectum Vol. 50; no. 9; pp. 1377 - 1383
Main Authors:	Belizon, A, Balik, E, Kirman, I, Remotti, H, Ciau, N, Jain, S, Whelan, R L
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Secaucus, NJ The ASCRS 01-09-2007 Springer Lippincott Williams & Wilkins Ovid Technologies
Subjects:	Animals Azoxymethane - toxicity Biological and medical sciences Colitis - chemically induced Colitis - complications Colitis - pathology Colonic Neoplasms - etiology Colonic Neoplasms - pathology Colonic Neoplasms - prevention & control Disease Progression Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Insulin-Like Growth Factor Binding Protein 3 - therapeutic use Medical sciences Mice Mice, Transgenic Neoplasms, Experimental Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome Tumors Intraperitoneal administration Anthropometry Body weight Adenoma Epidemiology Carcinogenesis Inflammatory disease Incidence Insulin like growth factor binding protein Blood substitute Intestinal disease Colon premalignant lesion Benign neoplasm Premalignant lesion Oral administration Corporal biometry Colonic disease Dextran Inflammatory bowel disease Crohn disease Insulin-like growth factor binding protein-3 Chronic Treatment Animal Digestive diseases Colitis Growth factor Ulcerative colitis
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Summary:	PURPOSE: METHODS: RESULTS:A total of 20 mice (10 in each group) were included in the study. The severity of colitis was not significantly different between the two groups (mean colitis score wild-type = 13.2; IFGB-3 transgenic = 11; P = not significant). The average number of aberrant crypt foci per colon was significantly lower in the IFGB-3 transgenic mice compared with the wild-type mice (1.5 ± 1.4 vs. 4.5 ± 2.7, respectively; P < 0.0001). The number of adenomas per colon was significantly lower in IFGB-3 transgenic group (1.2 ± 1.8) compared with the wild-type mice (3.7 ± 2.7; P = 0.005). In addition the average size of adenomas was significantly smaller in IFGB-3 transgenic mice (1.4 ± 1.3 mm) compared with the wild-type mice (2.6 ± 2 mm; P = 0.013). CONCLUSIONS:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-007-0258-x