Search Results - "Ciani, Yari"

Two distinct immunopathological profiles in autopsy lungs of COVID-19 by Nienhold, Ronny, Ciani, Yari, Koelzer, Viktor H., Tzankov, Alexandar, Haslbauer, Jasmin D., Menter, Thomas, Schwab, Nathalie, Henkel, Maurice, Frank, Angela, Zsikla, Veronika, Willi, Niels, Kempf, Werner, Hoyler, Thomas, Barbareschi, Mattia, Moch, Holger, Tolnay, Markus, Cathomas, Gieri, Demichelis, Francesca, Junt, Tobias, Mertz, Kirsten D.

“…Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a…”
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Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer by Walerych, Dawid, Lisek, Kamil, Sommaggio, Roberta, Piazza, Silvano, Ciani, Yari, Dalla, Emiliano, Rajkowska, Katarzyna, Gaweda-Walerych, Katarzyna, Ingallina, Eleonora, Tonelli, Claudia, Morelli, Marco J., Amato, Angela, Eterno, Vincenzo, Zambelli, Alberto, Rosato, Antonio, Amati, Bruno, Wiśniewski, Jacek R., Del Sal, Giannino

“…In cancer, the tumour suppressor gene TP53 undergoes frequent missense mutations that endow mutant p53 proteins with oncogenic properties. Until now, a…”
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Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism by Antoniali, Giulia, Serra, Fabrizio, Lirussi, Lisa, Tanaka, Mikiei, D’Ambrosio, Chiara, Zhang, Shiheng, Radovic, Slobodanka, Dalla, Emiliano, Ciani, Yari, Scaloni, Andrea, Li, Mengxia, Piazza, Silvano, Tell, Gianluca

“…Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress…”
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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action by Campaner, Elena, Rustighi, Alessandra, Zannini, Alessandro, Cristiani, Alberto, Piazza, Silvano, Ciani, Yari, Kalid, Ori, Golan, Gali, Baloglu, Erkan, Shacham, Sharon, Valsasina, Barbara, Cucchi, Ulisse, Pippione, Agnese Chiara, Lolli, Marco Lucio, Giabbai, Barbara, Storici, Paola, Carloni, Paolo, Rossetti, Giulia, Benvenuti, Federica, Bello, Ezia, D’Incalci, Maurizio, Cappuzzello, Elisa, Rosato, Antonio, Del Sal, Giannino

“…The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly…”
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miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1 by DINAMI, Roberto, ERCOLANI, Cristiana, BENETTI, Roberta, MOTTOLESE, Marcella, SCHNEIDER, Claudio, BLANDINO, Giovanni, SCHOEFTNER, Stefan, PETTI, Eleonora, PIAZZA, Silvano, CIANI, Yari, SESTITO, Rosanna, SACCONI, Andrea, BIAGIONI, Francesca, LE SAGE, Carlos, AGAMI, Reuven

“…Telomeres consist of DNA tandem repeats that recruit the multiprotein complex shelterin to build a chromatin structure that protects chromosome ends. Although…”
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HMGA1 promotes breast cancer angiogenesis supporting the stability, nuclear localization and transcriptional activity of FOXM1 by Zanin, Rossella, Pegoraro, Silvia, Ros, Gloria, Ciani, Yari, Piazza, Silvano, Bossi, Fleur, Bulla, Roberta, Zennaro, Cristina, Tonon, Federica, Lazarevic, Dejan, Stupka, Elia, Sgarra, Riccardo, Manfioletti, Guidalberto

“…Breast cancer is the most common malignancy in women worldwide. Among the breast cancer subtypes, triple-negative breast cancer (TNBC) is the most aggressive…”
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Epigenetic silencing of miR-296 and miR-512 ensures hTERT dependent apoptosis protection and telomere maintenance in basal-type breast cancer cells by Dinami, Roberto, Buemi, Valentina, Sestito, Rosanna, Zappone, Antonina, Ciani, Yari, Mano, Miguel, Petti, Eleonora, Sacconi, Andrea, Blandino, Giovanni, Giacca, Mauro, Piazza, Silvano, Benetti, Roberta, Schoeftner, Stefan

“…The catalytic subunit of the telomerase complex, hTERT, ensures unlimited proliferative potential of cancer cells by maintaining telomere function and…”
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High-throughput assessment of the antibody profile in ovarian cancer ascitic fluids by Antony, Frank, Deantonio, Cecilia, Cotella, Diego, Soluri, Maria Felicia, Tarasiuk, Olga, Raspagliesi, Francesco, Adorni, Fulvio, Piazza, Silvano, Ciani, Yari, Santoro, Claudio, Macor, Paolo, Mezzanzanica, Delia, Sblattero, Daniele

“…The identification of effective biomarkers for early diagnosis, prognosis, and response to treatments remains a challenge in ovarian cancer (OC) research…”
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Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations by Fedrizzi, Tarcisio, Ciani, Yari, Lorenzin, Francesca, Cantore, Thomas, Gasperini, Paola, Demichelis, Francesca

“…[Display omitted] Mutual Exclusivity analysis of genomic aberrations contributes to the exploration of potential synthetic lethal (SL) relationships thus…”
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GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration by Scolz, Massimilano, Widlund, Per O, Piazza, Silvano, Bublik, Debora Rosa, Reber, Simone, Peche, Leticia Y, Ciani, Yari, Hubner, Nina, Isokane, Mayumi, Monte, Martin, Ellenberg, Jan, Hyman, Anthony A, Schneider, Claudio, Bird, Alexander W

“…The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is…”
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Critical role of lysosomes in the dysfunction of human Cardiac Stem Cells obtained from failing hearts by Gianfranceschi, Giuseppe, Caragnano, Angela, Piazza, Silvano, Manini, Ivana, Ciani, Yari, Verardo, Roberto, Toffoletto, Barbara, Finato, Nicoletta, Livi, Ugolino, Beltrami, Carlo Alberto, Scoles, Giacinto, Aleksova, Aneta, Cesselli, Daniela, Beltrami, Antonio Paolo

“…Abstract The in vivo reparative potential of Cardiac Stem Cells (CSC), cultured from explanted failing hearts (E-), is impaired by cellular senescence…”
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HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness by Pegoraro, Silvia, Ros, Gloria, Piazza, Silvano, Sommaggio, Roberta, Ciani, Yari, Rosato, Antonio, Sgarra, Riccardo, Del Sal, Giannino, Manfioletti, Guidalberto

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Integrating extracellular vesicle and circulating cell‐free DNA analysis using a single plasma aliquot improves the detection of HER2 positivity in breast cancer patients by Mugoni, Vera, Ciani, Yari, Quaini, Orsetta, Tomasini, Simone, Notarangelo, Michela, Vannuccini, Federico, Marinelli, Alessia, Leonardi, Elena, Pontalti, Stefano, Martinelli, Angela, Rossetto, Daniele, Pesce, Isabella, Mansy, Sheref S., Barbareschi, Mattia, Ferro, Antonella, Caffo, Orazio, Attard, Gerhardt, Di Vizio, Dolores, D'Agostino, Vito Giuseppe, Nardella, Caterina, Demichelis, Francesca

“…Multi‐analyte liquid biopsies represent an emerging opportunity for non‐invasive cancer assessment. We developed ONCE (One Aliquot for Circulating Elements),…”
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Specific Mesothelial Signature Marks the Heterogeneity of Mesenchymal Stem Cells From High‐Grade Serous Ovarian Cancer by Verardo, Roberto, Piazza, Silvano, Klaric, Enio, Ciani, Yari, Bussadori, Giulio, Marzinotto, Stefania, Mariuzzi, Laura, Cesselli, Daniela, Beltrami, Antonio P., Mano, Miguel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Beltrami, Carlo A., Schneider, Claudio

“…Mesenchymal stem/stromal cells (MSCs) are the precursors of various cell types that compose both normal and cancer tissue microenvironments. In order to…”
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Circulating RNAs in prostate cancer patients by Mugoni, Vera, Ciani, Yari, Nardella, Caterina, Demichelis, Francesca

“…Growing bodies of evidence have demonstrated that the identification of prostate cancer (PCa) biomarkers in the patients’ blood and urine may remarkably…”
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Casting a wider net: The clinical potential of EV transcriptomics in multi-analyte liquid biopsy by Ciani, Yari, Nardella, Caterina, Demichelis, Francesca

“…Cancer cells release cell-free DNA (cfDNA) and extracellular vesicles (EVs) into the bloodstream, allowing disease non-invasive monitoring. In this issue of…”
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Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells by Lisek, Kamil, Campaner, Elena, Ciani, Yari, Walerych, Dawid, Del Sal, Giannino

“…NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated…”
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PIN1 in breast development and cancer: a clinical perspective by Rustighi, Alessandra, Zannini, Alessandro, Campaner, Elena, Ciani, Yari, Piazza, Silvano, Del Sal, Giannino

“…Mammary gland development, various stages of mammary tumorigenesis and breast cancer progression have the peptidyl-prolyl cis/trans isomerase PIN1 at their…”
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A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness by Pegoraro, Silvia, Ros, Gloria, Ciani, Yari, Sgarra, Riccardo, Piazza, Silvano, Manfioletti, Guidalberto

“…High Mobility Group A1 (HMGA1) is an architectural chromatin factor that promotes neoplastic transformation and progression. However, the mechanism by which…”
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ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA by Casiraghi, Nicola, Orlando, Francesco, Ciani, Yari, Xiang, Jenny, Sboner, Andrea, Elemento, Olivier, Attard, Gerhardt, Beltran, Himisha, Demichelis, Francesca, Romanel, Alessandro

“…Abstract Motivation The use of liquid biopsies for cancer patients enables the non-invasive tracking of treatment response and tumor dynamics through single or…”
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