Search Results - "Ciaffoni, F"

Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits by Bravo, E, D'Amore, E, Ciaffoni, F, Mammola, C L

“…There is a general consensus that liver fibrosis in humans is potentially reversible, while scepticism prevails on the concept that cirrhosis can be truly…”
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The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature by Zingariello, M, Sancillo, L, Martelli, F, Ciaffoni, F, Marra, M, Varricchio, L, Rana, R A, Zhao, C, Crispino, J D, Migliaccio, A R

“…Myelofibrosis (MF) is characterized by hyperactivation of thrombopoietin (TPO) signaling, which induces a RPS14 deficiency that de-regulates GATA1 in…”
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The thrombopoietin/MPL axis is activated in the Gata1 low mouse model of myelofibrosis and is associated with a defective RPS14 signature by Zingariello, M, Sancillo, L, Martelli, F, Ciaffoni, F, Marra, M, Varricchio, L, Rana, R A, Zhao, C, Crispino, J D, Migliaccio, A R

“…Myelofibrosis (MF) is characterized by hyperactivation of thrombopoietin (TPO) signaling, which induces a RPS14 deficiency that de-regulates GATA1 in…”
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The N370S (Asn super(370)-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C by Salvioli, Rosa, Tatti, Massimo, Scarpa, Susanna, Moavero, Sabrina Maria, Ciaffoni, Fiorella, Felicetti, Federica, Kaneski, Christine R, Brady, Roscoe O, Vaccaro, Anna Maria

“…The properties of the endolysosomal enzyme GCase (glucosylceramidase), carrying the most prevalent mutation observed in Gaucher patients, namely substitution…”
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Saposins and their interaction with lipids by VACCARO, A. M, SALVIOLI, R, TATTI, M, CIAFFONI, F

“…The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a…”
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Glucosylceramidase Mass and Subcellular Localization Are Modulated by Cholesterol in Niemann-Pick Disease Type C by Salvioli, Rosa, Scarpa, Susanna, Ciaffoni, Fiorella, Tatti, Massimo, Ramoni, Carlo, Vanier, Marie T., Vaccaro, Anna Maria

“…Niemann-Pick disease type C (NPC) is characterized by the accumulation of cholesterol and sphingolipids in the late endosomal/lysosomal compartment. The…”
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Interaction of saposin D with membranes: effect of anionic phospholipids and sphingolipids by Ciaffoni, Fiorella, Tatti, Massimo, Salvioli, Rosa, Vaccaro, Anna Maria

“…Saposin (Sap) D is an endolysosomal protein that, together with three other similar proteins, Sap A, Sap B and Sap C, is involved in the degradation of…”
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Saposin D Solubilizes Anionic Phospholipid-containing Membranes by Ciaffoni, F, Salvioli, R, Tatti, M, Arancia, G, Crateri, P, Vaccaro, A M

“…Saposin (Sap) D is a late endosomal/lysosomal small protein, generated together with three other similar proteins, Sap A, B, and C, from the common precursor,…”
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Polymorphism of galactose-1-phosphate uridyltransferase in the Albanian and Croatian settlements of Molise (Italy) by Vaccaro, Anna Maria, Mandara, I., Ciaffoni, F., Biondi, G.

“…Four Albanian and three Croatian communities settled in Molise (Italy) have been investigated for galactose-1-phosphate uridyltransferase (GALT) polymorphism…”
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Polymorphism of erythrocyte galactose-1-phosphate uridyl-transferase in Italy: segregation analysis in 693 families by Vaccaro, A M, Mandara, I, Muscillo, M, Ciaffoni, F, De Pellegrin, S, Benincasa, A, Novelletto, A, Terrenato, L

“…In the course of a population study in Italy, blood samples collected from 802 unrelated newborns and both their parents (when possible) have been examined for…”
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Further studies on the reconstitution of glucosylceramidase activity by Sap C and anionic phospholipids by Salvioli, Rosa, Tatti, Massimo, Ciaffoni, Fiorella, Vaccaro, Anna Maria

“…The reconstitution of the activity of the lysosomal enzyme glucosylceramidase requires anionic phospholipids and, at least, a protein factor, saposin C (Sap…”
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pH-dependent Conformational Properties of Saposins and Their Interactions with Phospholipid Membranes (∗) by Vaccaro, Anna Maria, Ciaffoni, Fiorella, Tatti, Massimo, Salvioli, Rosa, Barca, Alessandra, Tognozzi, Deborah, Scerch, Chiara

“…Saposins A, B, C, and D are small lysosomal glycoproteins released by proteolysis from a single precursor polypeptide, prosaposin. We have presently…”
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Structural analysis of saposin C and B. Complete localization of disulfide bridges by Vaccaro, A.M. (Istituto Superiore di Sanita, Roma, Italy.), Salvioli, R, Barca, A, Tatti, M, Ciaffoni, F, Maras, B, Siciliano, R, Zappacosta, F, Amoresano, A, Pucci, P

“…Saposins A, B, C, and D are a group of homologous glycoproteins derived from a single precursor, prosaposin, and apparently involved in the stimulation of the…”
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Effect of Saposins A and C on the Enzymatic Hydrolysis of Liposomal Glucosylceramide by Vaccaro, Anna Maria, Tatti, Massimo, Ciaffoni, Fiorella, Salvioli, Rosa, Barca, Alessandra, Scerch, Chiara

“…The degradation of glucosylceramide in lysosomes is accomplished by glucosylceramidase with the assistance of, at least, another protein, saposin C (Sap C),…”
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Factors affecting the binding of glucosylceramidase to its natural substrate dispersion by Vaccaro, A M, Tatti, M, Ciaffoni, F, Salvioli, R

“…This paper reports the results of ultracentrifugation experiments devised for investigating the interactions occurring in the conditions of the enzymatic assay…”
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Saposin C induces pH-dependent destabilization and fusion of phosphatidylserine-containing vesicles by Vaccaro, Anna Maria, Tatti, Massimo, Ciaffoni, Fiorella, Salvioli, Rosa, Serafino, Annalucia, Barca, Alessandra

“…We have previously shown that saposin C (Sap C), a glucosylceramidase activator protein, interacts with phosphatidylserine (PS) large unilamellar vesicles…”
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Function of saposin C in the reconstitution of glucosylceramidase by phosphatidylserine liposomes by Vaccaro, Anna Maria, Tatti, Massimo, Ciaffoni, Fiorella, Salvioli, Rosa, Maras, Bruno, Barca, Alessandra

“…The function of saposin C (Sap C), a glucosylceramidase activator protein, in the enzyme stimulation by phosphatidylserine (PS) liposomes has been…”
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Structural and membrane‐binding properties of saposin D by Tatti, Massimo, Salvioli, Rosa, Ciaffoni, Fiorella, Pucci, Piero, Andolfo, Annapaola, Amoresano, Angela, Vaccaro, Anna Maria

“…Saposin D is generated together with three similar proteins, saposins A, B and C, from a common precursor, called prosaposin, in acidic organelles such as late…”
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Function of saposin C in the reconstitution of glycosylceramidase by phosphatidylserine liposomes by VACCARO, A. M, TATTI, M, CIAFFONI, F, SALVIOLI, R, MARAS, B, BARCA, A

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Correlation between the activity of glucosylceramidase and its binding to glucosylceramide-containing liposomes. Role of acidic phospholipids and fatty acids by Vaccaro, A M, Tatti, M, Salvioli, R, Ciaffoni, F, Gallozzi, E

“…Optimal enzymatic hydrolysis of glucosylceramide inserted into liposomes has been obtained when both acidic phospholipids and the appropriate fatty acids were…”
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