Search Results - "Ciaccio, Natalie"

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter by Connolly, Brian D., Petry, Chris, Yadav, Sandeep, Demeule, Barthélemy, Ciaccio, Natalie, Moore, Jamie M.R., Shire, Steven J., Gokarn, Yatin R.

“…Weak protein-protein interactions are thought to modulate the viscoelastic properties of concentrated antibody solutions. Predicting the viscoelastic behavior…”
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Nanostructured Thin Film Polymer Devices for Constant-Rate Protein Delivery by Bernards, Daniel A, Lance, Kevin D, Ciaccio, Natalie A, Desai, Tejal A

“…Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein…”
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Effects of Disulfide Bond Formation and Protein Helicity on the Aggregation of Activating Transcription Factor 5 by Ciaccio, Natalie A, Laurence, Jennifer S

“…Amorphous aggregation is a major problem for protein biopharmaceuticals, and aggregate formation in a drug formulation can have serious health implications for…”
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In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device by Lance, Kevin D., Bernards, Daniel A., Ciaccio, Natalie A., Good, Samuel D., Mendes, Thaís S., Kudisch, Max, Chan, Elliot, Ishikiriyama, Mynna, Bhisitkul, Robert B., Desai, Tejal A.

“…Current administration of ranibizumab and other therapeutic macromolecules to the vitreous and retina carries ocular risks, a high patient treatment burden,…”
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Influence of the Valine Zipper Region on the Structure and Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5) by Ciaccio, Natalie A, Reynolds, T. Steele, Middaugh, C. Russell, Laurence, Jennifer S

“…Protein aggregation is a major problem for biopharmaceuticals. While the control of aggregation is critically important for the future of protein…”
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High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5 by Ciaccio, Natalie A., Moreno, Matthew L., Bauer, Rachel L., Laurence, Jennifer S.

“…Activating transcription factor 5 (ATF5) recently has been demonstrated to play a critical role in promoting the survival of human glioblastoma cells…”
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A comparison of background membrane imaging versus flow technologies for subvisible particle analysis of biologics by Vargas, Stephanie K., Eskafi, Aydin, Carter, Eric, Ciaccio, Natalie

“…[Display omitted] A recently developed high-throughput background membrane imaging (BMI) technique, the HORIZON, was assessed for its ability to quantify…”
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Planar Microdevices for Enhanced In Vivo Retention and Oral Bioavailability of Poorly Permeable Drugs by Chirra, Hariharasudhan D., Shao, Ling, Ciaccio, Natalie, Fox, Cade B., Wade, Jennifer M., Ma, Averil, Desai, Tejal A.

“…The development of novel oral drug delivery platforms for administering therapeutics in a safe and effective manner through the harsh gastrointestinal…”
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Polycaprolactone thin-film drug delivery systems: Empirical and predictive models for device design by Schlesinger, Erica, Ciaccio, Natalie, Desai, Tejal A

“…To define empirical models and parameters based on theoretical equations to describe drug release profiles from two polycaprolactone thin-film drug delivery…”
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Involvement of endothelin in morphine tolerance in neuroblastoma (SH-SY5Y) cells by Bhalla, Shaifali, Ciaccio, Natalie, Wang, Zaijie Jim, Gulati, Anil

“…Long-term use of morphine in pain management leads to adverse effects, such as development of antinociceptive tolerance. We have previously shown the…”
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Investigating the Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5) by Ciaccio, Natalie A

“…Protein aggregation is a major problem for biopharmaceuticals. Aggregate formation in a drug formulation can have serious health implications for the patient…”
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Investigating the Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5) by Ciaccio, Natalie A

“…Protein aggregation is a major problem for biopharmaceuticals. Aggregate formation in a drug formulation can have serious health implications for the patient…”
Get full text