Search Results - "Chylinski, Daphne"
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Complexity and compositionality in fluid intelligence
Published in Proceedings of the National Academy of Sciences - PNAS (16-05-2017)“…Compositionality, or the ability to build complex cognitive structures from simple parts, is fundamental to the power of the human mind. Here we relate this…”
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Timely coupling of sleep spindles and slow waves is linked to early amyloid-β burden and predicts memory decline
Published in eLife (31-05-2022)“…Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer's disease (AD). While the fine-tuned coalescence of sleep microstructure…”
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Increased cortical excitability but stable effective connectivity index during attentional lapses
Published in Sleep (New York, N.Y.) (01-06-2021)“…Abstract Modern lifestyle curtails sleep and increases nighttime work and leisure activities. This has a deleterious impact on vigilance and attention,…”
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Sleep–wake regulation and the hallmarks of the pathogenesis of Alzheimer’s disease
Published in Sleep (New York, N.Y.) (01-04-2019)“…Abstract While efficient treatments for Alzheimer’s disease (AD) remain elusive, a growing body of research has highlighted sleep–wake regulation as a…”
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Variability of sleep stage scoring in late midlife and early old age
Published in Journal of sleep research (01-02-2022)“…Sleep stage scoring can lead to important inter‐expert variability. Although likely, whether this issue is amplified in older populations, which show…”
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Effort During Prolonged Wakefulness Is Associated With Performance to Attentional and Executive Tasks but Not With Cortical Excitability in Late-Middle-Aged Healthy Individuals
Published in Neuropsychology (01-01-2023)“…Objective: Sleep loss negatively affects brain function with repercussion not only on objective measures of performance but also on many subjective dimensions,…”
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In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
Published in Scientific reports (27-11-2023)“…The regional integrity of brain subcortical structures has been implicated in sleep–wake regulation, however, their associations with sleep parameters remain…”
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Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers
Published in Neurobiology of disease (01-12-2022)“…Insomnia disorder (ID) is the second most common neuropsychiatric disorder. Its socioeconomic burden is enormous while diagnosis and treatment are difficult. A…”
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Prediction of cognitive decline in healthy aging based on neuropsychiatric symptoms and PET-biomarkers of Alzheimer's disease
Published in Journal of neurology (01-04-2024)“…Neuropsychiatric symptoms (NPS) have been associated with a risk of accelerated cognitive decline or conversion to dementia of the Alzheimer’s Disease (AD)…”
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Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife
Published in Sleep (New York, N.Y.) (09-11-2022)“…Abstract Study Objectives The ability to generate slow waves (SW) during non-rapid eye movement (NREM) sleep decreases as early as the 5th decade of life,…”
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Relationship between brain AD biomarkers and episodic memory performance in healthy aging
Published in Brain and cognition (01-03-2021)“…•AD brain biomarkers are present in healthy aging and influence memory performance.•Hippocampal atrophy was associated with visual episodic memory after 60…”
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Using quantitative magnetic resonance imaging to track cerebral alterations in multiple sclerosis brain: A longitudinal study
Published in Brain and behavior (01-05-2023)“…Introduction Quantitative MRI quantifies tissue microstructural properties and supports the characterization of cerebral tissue damages. With an MPM protocol,…”
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Heterogeneity in the links between sleep arousals, amyloid-β, and cognition
Published in JCI insight (22-12-2021)“…BACKGROUNDTight relationships between sleep quality, cognition, and amyloid-β (Aβ) accumulation, a hallmark of Alzheimer's disease (AD) neuropathology, have…”
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Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status
Published in Frontiers in aging neuroscience (28-05-2021)“…Studies exploring the simultaneous influence of several physiological and environmental factors on domain-specific cognition in late middle-age remain scarce…”
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Author Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
Published in Scientific reports (13-03-2024)Get full text
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Locus coeruleus activity while awake is associated with REM sleep quality in older individuals
Published in JCI insight (23-10-2023)“…BACKGROUNDThe locus coeruleus (LC) is the primary source of norepinephrine in the brain and regulates arousal and sleep. Animal research shows that it plays…”
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Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load
Published in Aging (Albany, NY.) (08-09-2019)“…We investigated whether cognitive fitness in late midlife is associated with physiological and psychological factors linked to increased risk of age-related…”
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Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging
Published in JCI insight (25-01-2021)“…BACKGROUNDNeuronal hyperexcitability characterizes the early stages of Alzheimer's disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein…”
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Validation of an Automatic Arousal Detection Algorithm for Whole-Night Sleep EEG Recordings
Published in Clocks & Sleep (Online) (01-09-2020)“…Arousals during sleep are transient accelerations of the EEG signal, considered to reflect sleep perturbations associated with poorer sleep quality. They are…”
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Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations
Published in Communications biology (2019)“…Age-related cognitive decline arises from alterations in brain structure as well as in sleep-wake regulation. Here, we investigated whether preserved…”
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