Search Results - "Chwalenia, Katarzyna"

Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD by Hanson, Britt, Stenler, Sofia, Ahlskog, Nina, Chwalenia, Katarzyna, Svrzikapa, Nenad, Coenen-Stass, Anna M.L., Weinberg, Marc S., Wood, Matthew J.A., Roberts, Thomas C.

“…Duchenne muscular dystrophy (DMD) is the most prevalent inherited myopathy affecting children, caused by genetic loss of the gene encoding the dystrophin…”
Get full text

miR-146a deficiency does not aggravate muscular dystrophy in mdx mice by Bronisz-Budzyńska, Iwona, Chwalenia, Katarzyna, Mucha, Olga, Podkalicka, Paulina, Karolina-Bukowska-Strakova, Józkowicz, Alicja, Łoboda, Agnieszka, Kozakowska, Magdalena, Dulak, Józef

“…Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and…”
Get full text

Connections between Transcription Downstream of Genes and cis-SAGe Chimeric RNA by Chwalenia, Katarzyna, Qin, Fujun, Singh, Sandeep, Tangtrongstittikul, Panjapon, Li, Hui

“…cis-Splicing between adjacent genes (cis-SAGe) is being recognized as one way to produce chimeric fusion RNAs. However, its detail mechanism is not clear…”
Get full text

Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy by Winkelsas, Audrey M., Grunseich, Christopher, Harmison, George G., Chwalenia, Katarzyna, Rinaldi, Carlo, Hammond, Suzan M., Johnson, Kory, Bowerman, Melissa, Arya, Sukrat, Talbot, Kevin, Wood, Matthew J., Fischbeck, Kenneth H.

“…Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All patients have at least one copy…”
Get full text

Chimeric RNAs in cancer and normal physiology by Chwalenia, Katarzyna, Facemire, Loryn, Li, Hui

“…Traditionally, chimeric RNAs were considered to be exclusive to cancer cells. When occasionally observed in normal samples, they were usually considered to be…”
Get full text

A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes by Chwalenia, Katarzyna, Qin, Fujun, Singh, Sandeep, Li, Hui

“…Abstract Chimeric RNAs generated by cis-splicing between adjacent genes (cis-SAGe) are increasingly recognized as a widespread phenomenon. These chimeric…”
Get full text

A switch of N-glycosylation of proteome and secretome during differentiation of intestinal epithelial cells by Link-Lenczowski, Paweł, Jastrzębska, Martyna, Chwalenia, Katarzyna, Pierzchalska, Małgorzata, Leja-Szpak, Anna, Bonior, Joanna, Pierzchalski, Piotr, Jaworek, Jolanta

“…The maintenance of homeostasis of the intestinal epithelium depends on the complex process of epithelial cells differentiation, which repeatedly continues…”
Get full text

Control of backbone chemistry and chirality boost oligonucleotide splice switching activity by Kandasamy, Pachamuthu, McClorey, Graham, Shimizu, Mamoru, Kothari, Nayantara, Alam, Rowshon, Iwamoto, Naoki, Kumarasamy, Jayakanthan, Bommineni, Gopal R, Bezigian, Adam, Chivatakarn, Onanong, Butler, David C D, Byrne, Michael, Chwalenia, Katarzyna, Davies, Kay E, Desai, Jigar, Shelke, Juili Dilip, Durbin, Ann F, Ellerington, Ruth, Edwards, Ben, Godfrey, Jack, Hoss, Andrew, Liu, Fangjun, Longo, Kenneth, Lu, Genliang, Marappan, Subramanian, Oieni, Jacopo, Paik, Ik-Hyeon, Estabrook, Erin Purcell, Shivalila, Chikdu, Tischbein, Maeve, Kawamoto, Tomomi, Rinaldi, Carlo, Rajão-Saraiva, Joana, Tripathi, Snehlata, Yang, Hailin, Yin, Yuan, Zhao, Xiansi, Zhou, Cong, Zhang, Jason, Apponi, Luciano, Wood, Matthew J A, Vargeese, Chandra

“…Abstract Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular…”
Get full text

Exon skipping induces uniform dystrophin rescue with dose-dependent restoration of serum miRNA biomarkers and muscle biophysical properties by Chwalenia, Katarzyna, Oieni, Jacopo, Zemła, Joanna, Lekka, Małgorzata, Ahlskog, Nina, Coenen-Stass, Anna M.L., McClorey, Graham, Wood, Matthew J.A., Lomonosova, Yulia, Roberts, Thomas C.

“…Therapies that restore dystrophin expression are presumed to correct Duchenne muscular dystrophy (DMD), with antisense-mediated exon skipping being the leading…”
Get full text

Dystrophin involvement in peripheral circadian SRF signalling by Betts, Corinne A, Jagannath, Aarti, van Westering, Tirsa LE, Bowerman, Melissa, Banerjee, Subhashis, Meng, Jinhong, Falzarano, Maria Sofia, Cravo, Lara, McClorey, Graham, Meijboom, Katharina E, Bhomra, Amarjit, Lim, Wooi Fang, Rinaldi, Carlo, Counsell, John R, Chwalenia, Katarzyna, O'Donovan, Elizabeth, Saleh, Amer F, Gait, Michael J, Morgan, Jennifer E, Ferlini, Alessandra, Foster, Russell G, Wood, Matthew Ja

“…Absence of dystrophin, an essential sarcolemmal protein required for muscle contraction, leads to the devastating muscle-wasting disease Duchenne muscular…”
Get full text