Search Results - "Chursov, Andrey"

Conservation of mRNA secondary structures may filter out mutations in Escherichia coli evolution by Chursov, Andrey, Frishman, Dmitrij, Shneider, Alexander

“…Recent reports indicate that mutations in viral genomes tend to preserve RNA secondary structure, and those mutations that disrupt secondary structural…”
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RNAtips: Analysis of temperature-induced changes of RNA secondary structure by Chursov, Andrey, Kopetzky, Sebastian J, Bocharov, Gennady, Frishman, Dmitrij, Shneider, Alexander

“…Although multiple biological phenomena are related to temperature (e.g. elevation of body temperature due to an illness, adaptation to environmental…”
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1295 Integrating drug structure and target binding affinity for improved prediction of survival in cancer patients treated with immune checkpoint inhibitors by Kumar, Sunil, Kuperwaser, Felicia, Tracy, Dillon, Sherman, Jeff, Chursov, Andrey, Vucic, Emily, Baron, Maayan

“…BackgroundImmune checkpoint inhibitors (ICIs) have transformed cancer therapy, yet their response rates remain modest, ranging from 20–40% across different…”
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1296 Reconstructing gene expression from clinical and genetic panel data for predictions of tumor microenvironment features and response to immune checkpoint inhibitor therapy by Kuperwaser, Felicia, Kumar, Sunil, Tracy, Dillon, Sherman, Jeff, Chursov, Andrey, Baron, Maayan, Vucic, Emily

“…BackgroundThe development of immune checkpoint inhibitor (ICI) therapy has fundamentally changed the landscape of cancer treatment. While ICIs have exhibited…”
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Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector by Venanzi, Franco, Shifrin, Victor, Sherman, Michael, Gabai, Vladimir, Kiselev, Oleg, Komissarov, Andrey, Grudinin, Mikhail, Shartukova, Maria, Romanovskaya-Romanko, Ekaterina A, Kudryavets, Yuri, Bezdenezhnykh, Natalya, Lykhova, Oleksandra, Semesyuk, Nadiia, Concetti, Antonio, Tsyb, Anatoly, Filimonova, Marina, Makarchuk, Victoria, Yakubovsky, Raisa, Chursov, Andrey, Shcherbinina, Vita, Shneider, Alexander

“…Autophagy plays an important role in neoplastic transformation of cells and in resistance of cancer cells to radio- and chemotherapy. p62 (SQSTM1) is a key…”
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Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus by Chursov, Andrey, Kopetzky, Sebastian J., Leshchiner, Ignaty, Kondofersky, Ivan, Theis, Fabian J., Frishman, Dmitrij, Shneider, Alexander

“…For decades, cold-adapted, temperature-sensitive (ca/ts) strains of influenza A virus have been used as live attenuated vaccines. Due to their great public…”
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Use of a systems-biology informed machine learning model to predict drug response using clinically available NGS data by Baron, Maayan, Chursov, Andrey, Funkhouser, Brandon, Kaffey, Jacob, Kumar, Sunil, Komatsoulis, George Anthony, Kuperwaser, Felicia, Ramchandran, Maya, Sherman, Jeff, Vucic, Emily

“…3136 Background: Tremendous progress towards understanding the molecular underpinnings of cancer has ushered in an era of precision medicine, where actionable…”
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Abstract 2509: Analysis of clonal hematopoiesis-associated mutations in the cell-free DNA of advanced cancer patients by Yen, Jennifer, Quinn, Katie, Helman, Elena, Chursov, Andrey, Nance, Tracy, Jaimovich, Ariel, Banks, Kimberly, Franovic, Aleksandra, Gleitsman, Kristin, Latham, John, Yablonovitch, Arielle, Sikora, Marcin, Fairclough, Stephen, Chudova, Darya, Lanman, Richard B., Talasaz, AmirAli

“…Background: Clonal hematopoiesis (CH) is the acquisition of mutations in hematopoietic progenitor cells that can lead to clonal expansion. Recent studies…”
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Pilot study of p62 DNA vaccine in dogs with mammary tumors by Gabai, Vladimir, Venanzi, Franco M, Bagashova, Elena, Rud, Oksana, Mariotti, Francesca, Vullo, Cecilia, Catone, Giuseppe, Sherman, Michael Y, Concetti, Antonio, Chursov, Andrey, Latanova, Anastasia, Shcherbinina, Vita, Shifrin, Victor, Shneider, Alexander

“…Our previous data demonstrated profound anti-tumor and anti-metastatic effects of p62 (sqstm1) DNA vaccine in rodents with various types of transplantable…”
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Sequence-structure relationships in yeast mRNAs by Chursov, Andrey, Walter, Mathias C., Schmidt, Thorsten, Mironov, Andrei, Shneider, Alexander, Frishman, Dmitrij

“…It is generally accepted that functionally important RNA structure is more conserved than sequence due to compensatory mutations that may alter the sequence…”
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P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions by Halenova, Tatiana, Savchuk, Oleksii, Ostapchenko, Ludmila, Chursov, Andrey, Fridlyand, Nathan, Komissarov, Andrey B, Venanzi, Franco, Kolesnikov, Sergey I, Sufianov, Albert A, Sherman, Michael Y, Gabai, Vladimir L, Shneider, Alexander M

“…A high-calorie diet (HCD) induces two mutually exacerbating effects contributing to diet-induced obesity (DIO): impaired glucose metabolism and increased food…”
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Safety and efficacy of p62 DNA vaccine ELENAGEN in a first-in-human trial in patients with advanced solid tumors by Ponomarenko, Dmitry M, Klimova, Irina D, Chapygina, Yulia A, Dvornichenko, Viktoria V, Zhukova, Natalia V, Orlova, Rashida V, Manikhas, Georgy M, Zyryanov, Alexandr V, Burkhanova, Lilya A, Badrtdinova, Irina I, Oshchepkov, Basile N, Filippova, Elena V, Orlov, Sergei V, Kolesnikov, Sergei I, Sufianov, Albert A, Baum, Svetlana R, Zaitzeva, Olga Y, Komissarov, Andrey B, Grudinin, Mikhail P, Kiselev, Oleg I, Tsyb, Anatoly F, Venanzi, Franco, Shcherbinina, Vita, Chursov, Andrey, Gabai, Vladimir L, Shneider, Alexander M

“…Elenagen is a plasmid encoding p62/SQSTM1, the first DNA vaccine possessing two mutually complementing mechanisms of action: it elicits immune response against…”
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