Emergence of Candida auris in Russia

This paper reports the emergence of Candida auris infections in an intensive care unit at a hospital in Moscow. Forty-nine cases were diagnosed in 2016–2017, and the risk factors and antifungal susceptibilities are described. The 30-day all-cause mortality for 19 bloodstream infections in patients w...

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Bibliographic Details
Published in:	The Journal of hospital infection Vol. 102; no. 4; pp. 445 - 448
Main Authors:	Barantsevich, N.E., Orlova, O.E., Shlyakhto, E.V., Johnson, E.M., Woodford, N., Lass-Floerl, C., Churkina, I.V., Mitrokhin, S.D., Shkoda, A.S., Barantsevich, E.P.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2019
Subjects:	Candida auris ERG11 gene Mortality Phylogenetic analysis Risk factors South Asian clade Susceptibility Phylogenetic analysis Candida auris South Asian clade Susceptibility Mortality ERG11 gene Risk factors
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Summary:	This paper reports the emergence of Candida auris infections in an intensive care unit at a hospital in Moscow. Forty-nine cases were diagnosed in 2016–2017, and the risk factors and antifungal susceptibilities are described. The 30-day all-cause mortality for 19 bloodstream infections in patients who did not receive appropriate antifungal therapy was 42.1%. Phylogenetic analysis of the internal transcribed spacer and D1–D2 regions and K143R substitution in the ERG11 gene indicated that the studied C. auris strains were of South Asian origin. This first reported series of C. auris infections in Russia demonstrates the rapid dissemination of this species, and the need for international surveillance and control measures.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0195-6701 1532-2939
DOI:	10.1016/j.jhin.2019.02.021