Search Results - "Churchill, Thomas"

Preoperative opioid use is associated with worse patient outcomes after Total joint arthroplasty: a systematic review and meta-analysis by Goplen, C Michael, Verbeek, Wesley, Kang, Sung Hyun, Jones, C Allyson, Voaklander, Donald C, Churchill, Thomas A, Beaupre, Lauren A

“…A significant number of patients use opioids prior to total joint arthroplasty (TJA) in North America and there is growing concern that preoperative opioid use…”
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I-FABP as biomarker for the early diagnosis of acute mesenteric ischemia and resultant lung injury by Khadaroo, Rachel G, Fortis, Spyridon, Salim, Saad Y, Streutker, Catherine, Churchill, Thomas A, Zhang, Haibo

“…Acute mesenteric ischemia (AMI) is a life-threatening condition that can result in multiple organ injury and death. A timely diagnosis and treatment would have…”
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Metabolomic profiling to characterize acute intestinal ischemia/reperfusion injury by Khadaroo, Rachel G, Churchill, Thomas A, Tso, Victor, Madsen, Karen L, Lukowski, Chris, Salim, Saad Y

“…Sepsis and septic shock are the leading causes of death in critically ill patients. Acute intestinal ischemia/reperfusion (AII/R) is an adaptive response to…”
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Urine intestinal fatty acid-binding protein predicts acute mesenteric ischemia in patients by Salim, Saad Y., Young, Pang Y., Churchill, Thomas A., Khadaroo, Rachel G.

“…Acute mesenteric ischemia (AMI) has a high morbidity and mortality and often presents as a diagnostic challenge. Currently, there is no blood, urine, or…”
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Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study by Li, Yibo, Pederson, Jenelle L, Churchill, Thomas A, Wagg, Adrian S, Holroyd-Leduc, Jayna M, Alagiakrishnan, Kannayiram, Padwal, Raj S, Khadaroo, Rachel G

“…Frailty is a state of vulnerability to diverse stressors. We assessed the impact of frailty on outcomes after discharge in older surgical patients. We…”
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Thigh Ultrasound Used to Identify Frail Elderly Patients with Sarcopenia Undergoing Surgery: A Pilot Study by Salim, Saad Y., Al-Khathiri, Omar, Tandon, Puneeta, Baracos, Vickie E., Churchill, Thomas A., Warkentin, Lindsey M., Khadaroo, Rachel G.

“…Computed tomography (CT) scan quantifying skeletal muscle mass is the gold standard tool to identify sarcopenia. Unfortunately, high cost, limited…”
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Organ-Specific Solutions and Strategies for the Intestinal Preservation by Oltean, Mihai, Churchill, Thomas A.

“…Among the intraabdominal organs, the intestine is the most susceptible to storage injury and as a consequence its safe cold ischemic time in the clinic is…”
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Incidence and predictors of postoperative delirium in the older acute care surgery population: a prospective study by Saravana-Bawan, Bianka, Warkentin, Lindsey M., Rucker, Diana, Carr, Frances, Churchill, Thomas A., Khadaroo, Rachel G.

“…Among older inpatients, the highest incidence of delirium is within the surgical population. Limited data are available regarding postoperative delirium risk…”
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Hypoxia-increased expression of genes involved in inflammation, dedifferentiation, pro-fibrosis, and extracellular matrix remodeling of human bladder smooth muscle cells by Wiafe, Bridget, Adesida, Adetola, Churchill, Thomas, Adewuyi, Esther Ekpe, Li, Zack, Metcalfe, Peter

“…Partial bladder outlet obstruction (pBOO) is characterized by exaggerated stretch, hydrodynamic pressure, and inflammation which cause significant damage and…”
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Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis by Ewaschuk, Julia, Endersby, Ryan, Thiel, David, Diaz, Hugo, Backer, Jody, Ma, Mang, Churchill, Thomas, Madsen, Karen

“…A breakdown in intestinal barrier function and increased bacterial translocation are key events in the pathogenesis of sepsis and liver disease. Altering gut…”
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Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection by MANJI, Rizwan A, ZHU, Lin F, NIJJAR, Nimrit K, RAYNER, David C, KORBUTT, Greg S, CHURCHILL, Thomas A, RAJOTTE, Ray V, KOSHAL, Arvind, ROSS, David B

“…Glutaraldehyde fixation (G-F) decreases but likely does not eliminate the antigenicity of bioprosthetic heart valves. Rejection (with secondary dystrophic…”
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Oncostatin M Receptor Type II Knockout Mitigates Inflammation and Improves Survival from Sepsis in Mice by Salim, Saad Y, AlMalki, Nour, Macala, Kimberly F, Wiedemeyer, Alyssa, Mueller, Thomas F, Churchill, Thomas A, Bourque, Stephane L, Khadaroo, Rachel G

“…Sepsis remains one of the leading causes of death worldwide. Oncostatin M (OSM), an interleukin (IL)-6 family cytokine, can be found at high levels in septic…”
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Analysis of postdischarge costs following emergent general surgery in elderly patients by Eamer, Gilgamesh J, Clement, Fiona, Pederson, Jenelle L, Churchill, Thomas A, Khadaroo, Rachel G

“…As populations age, more elderly patients will undergo surgery. Frailty and complications are considered to increase in-hospital cost in older adults, but…”
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Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease by Tso, Victor K, Sydora, Beate C, Foshaug, Rae R, Churchill, Thomas A, Doyle, Jason, Slupsky, Carolyn M, Fedorak, Richard N

“…Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the…”
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Effect of preoperative long-term opioid therapy on patient outcomes after total knee arthroplasty: an analysis of multicentre population-based administrative data by Goplen, C Michael, Kang, Sung Hyun, Randell, Jason R, Jones, C Allyson, Voaklander, Donald C, Churchill, Thomas A, Beaupre, Lauren A

“…Up to 40% of patients are receiving opioids at the time of total knee arthroplasty (TKA) in the United States despite evidence suggesting opioids are…”
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Analysis of postdischarge costs following emergent general surgery in elderly patients by Eamer, Gilgamesh J, Clement, Fiona, Pederson, Jenelle L, Churchill, Thomas A, Khadaroo, Rachel G

“…As populations age, more elderly patients will undergo surgery. Frailty and complications are considered to increase in-hospital cost in older adults, but…”
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Surface Expression of Toll-Like Receptor 9 Is Upregulated on Intestinal Epithelial Cells in Response to Pathogenic Bacterial DNA by Ewaschuk, Julia B, Backer, Jody L, Churchill, Thomas A, Obermeier, Florian, Krause, Denis O, Madsen, Karen L

“…Colonic epithelial cells are constantly exposed to high levels of bacterial DNA in the intestinal lumen and must recognize and respond appropriately to…”
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Comparison of aortic valve allograft decellularization techniques in the rat by Meyer, Steven R., Chiu, Brian, Churchill, Thomas A., Zhu, Linfu, Lakey, Jonathan R.T., Ross, David B.

“…Rodent models have been essential to understanding the immune‐mediated failure of aortic valve allografts (AVAs). Decellularization has been proposed to reduce…”
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Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches by Lehr, Eric J., MD, PhD, Rayat, Gina R., PhD, Chiu, Brian, MD, Churchill, Thomas, PhD, McGann, Locksley E., PhD, Coe, James Y., MD, Ross, David B., MD

“…Objectives Allograft vascular tissue is important in the repair of complex structural lesions of the heart and great vessels, but induces a deleterious immune…”
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Sirolimus drug-eluting, hydrogel-impregnated polypropylene mesh reduces intra-abdominal adhesion formation in a mouse model by Maciver, Allison H., MD, McCall, Michael D., MD, Edgar, Ryan L., BSc, Thiesen, Aducio L., MD, PhD, Bigam, David L., MD, MSc, Churchill, Thomas A., PhD, Shapiro, A.M. James, MD, PhD

“…Background Prosthetic mesh is used frequently in abdominal wall hernia reconstruction but is prone to postoperative adhesion formation. Complications resulting…”
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