Search Results - "Churchill, Mair E.A."

The high mobility group box: the ultimate utility player of a cell by Malarkey, Christopher S., Churchill, Mair E.A.

“…High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure…”
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Structural and functional analysis of domains of the progesterone receptor by Hill, Krista K., Roemer, Sarah C., Churchill, Mair E.A., Edwards, Dean P.

“…► This paper reviews the structural dynamics of steroid hormone receptors. ► The hinge region and amino-terminal domain (NTD) are intrinsically disordered…”
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The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for non-sequence-specific DNA recognition by Murphy IV, Frank V., Sweet, Robert M., Churchill, Mair E.A.

“…The high mobility group (HMG) chromosomal proteins, which are common to all eukaryotes, bind DNA in a non‐sequence‐specific fashion to promote chromatin…”
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The histone shuffle: histone chaperones in an energetic dance by Das, Chandrima, Tyler, Jessica K., Churchill, Mair E.A.

“…Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex called chromatin in a manner that enables it to be rapidly accessed…”
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Structural Basis for the Histone Chaperone Activity of Asf1 by English, Christine M., Adkins, Melissa W., Carson, Joshua J., Churchill, Mair E.A., Tyler, Jessica K.

“…Anti-silencing function 1 (Asf1) is a highly conserved chaperone of histones H3/H4 that assembles or disassembles chromatin during transcription, replication,…”
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Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer by Duex, Jason E, Swain, Kalin E, Dancik, Garrett M, Paucek, Richard D, Owens, Charles, Churchill, Mair E A, Theodorescu, Dan

“…Urothelial carcinoma accounts for most of the bladder cancer cases. Using next-generation sequencing (NGS) technology, we found that a significant percentage…”
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De Novo Mutations in EBF3 Cause a Neurodevelopmental Syndrome by Sleven, Hannah, Welsh, Seth J., Yu, Jing, Churchill, Mair E.A., Wright, Caroline F., Henderson, Alex, Horvath, Rita, Rankin, Julia, Vogt, Julie, Magee, Alex, McConnell, Vivienne, Green, Andrew, King, Mary D., Cox, Helen, Armstrong, Linlea, Lehman, Anna, Nelson, Tanya N., Williams, Jonathan, Clouston, Penny, Hagman, James, Németh, Andrea H.

“…Early B cell factor 3 (EBF3) is an atypical transcription factor that is thought to influence the laminar formation of the cerebral cortex. Here, we report…”
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Watching flipping junctions by Churchill, Mair E.A

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Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A by Gangelhoff, Todd A, Mungalachetty, Purnima S, Nix, Jay C, Churchill, Mair E.A

“…The mitochondrial transcription factor A (mtTFA) is central to assembly and initiation of the mitochondrial transcription complex. Human mtTFA (h-mtTFA) is a…”
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Histone transfer among chaperones by Liu, Wallace H, Churchill, Mair E A

“…The eukaryotic processes of nucleosome assembly and disassembly govern chromatin dynamics, in which histones exchange in a highly regulated manner to promote…”
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Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding by Pascreau, Gaetan, Eckerdt, Frank, Churchill, Mair E.A, Maller, James L

“…Centrosomes have recently emerged as key regulators of the cell cycle. The G1/S transition requires a functional centrosome, and centrosomal localization of…”
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Structural Basis and Specificity of Acyl-Homoserine Lactone Signal Production in Bacterial Quorum Sensing by Watson, William T., Minogue, Timothy D., Val, Dale L., von Bodman, Susanne Beck, Churchill, Mair E.A.

“…Synthesis and detection of acyl-homoserine lactones (AHLs) enables many gram-negative bacteria to engage in quorum sensing, an intercellular signaling…”
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A Progesterone Receptor Co-activator (JDP2) Mediates Activity through Interaction with Residues in the Carboxyl-terminal Extension of the DNA Binding Domain by Hill, Krista K., Roemer, Sarah C., Jones, David N.M., Churchill, Mair E.A., Edwards, Dean P.

“…Progesterone receptor (PR) belongs to the nuclear receptor family of ligand-dependent transcription factors and mediates the major biological effects of…”
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N-(3-Hydroxyhexanoyl)-L-Homoserine Lactone Is the Biologically Relevant Quormone That Regulates the phz Operon of Pseudomonas chlororaphis Strain 30-84 by Khan, Sharik R, Herman, Jake, Krank, Jessica, Serkova, Natalie J, Churchill, Mair E.A, Suga, Hiroaki, Farrand, Stephen K

“…Phenazine production by Pseudomonas fluorescens 2-79 and P. chlororaphis isolates 30-84 and PCL1391 is regulated by quorum sensing through the activator PhzR…”
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Centrosomal localization of cyclins E and A: Structural similarities and functional differences by Pascreau, Gaetan, Churchill, Mair E.A., Maller, James L.

“…Recent identification of the modular CLS motifs responsible for cyclins A and E localization on centrosomes has revealed a tight linkage between the nuclear…”
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Mechanism of high-mobility group protein B enhancement of progesterone receptor sequence-specific DNA binding by Roemer, Sarah C, Adelman, James, Churchill, Mair E.A, Edwards, Dean P

“…The DNA-binding domain (DBD) of progesterone receptor (PR) is bipartite containing a zinc module core that interacts with progesterone response elements (PRE),…”
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The Aurora A and Aurora B Protein Kinases: A Single Amino Acid Difference Controls Intrinsic Activity and Activation by TPX2 by Eyers, Patrick A., Churchill, Mair E.A., Maller, James L.

“…The Aurora A and B protein kinases are key players in mitotic control and the etiology of human cancer. Despite the near identity of amino acid sequence in the…”
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The C-terminal Extension (CTE) of the Nuclear Hormone Receptor DNA Binding Domain Determines Interactions and Functional Response to the HMGB-1/-2 Co-regulatory Proteins by Melvin, Vida Senkus, Roemer, Sarah C., Churchill, Mair E.A., Edwards, Dean P.

“…Previously, we and others reported that the high mobility group proteins, HMGB-1/-2, enhance DNA binding in vitro and transactivation in situ by the steroid…”
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Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription by Dostal, Vishantie, Churchill, Mair E.A.

“…In eukaryotes, cytosine methylation of nuclear DNA at CpG sequences (5mCpG) regulates epigenetic inheritance through alterations in chromatin structure…”
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Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1 by Sauer, Paul V, Gu, Yajie, Liu, Wallace H, Mattiroli, Francesca, Panne, Daniel, Luger, Karolin, Churchill, Mair EA

“…Abstract Eukaryotic chromatin is a highly dynamic structure with essential roles in virtually all DNA-dependent cellular processes. Nucleosomes are a barrier…”
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