Search Results - "Churchill, Madeline J."

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs by Baptista, Marco A S, Dave, Kuldip D, Frasier, Mark A, Sherer, Todd B, Greeley, Melanie, Beck, Melissa J, Varsho, Julie S, Parker, George A, Moore, Cindy, Churchill, Madeline J, Meshul, Charles K, Fiske, Brian K

“…The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson's disease at 1-, 2-, 4-, 8-, 12-, and…”
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Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin by Churchill, Madeline J, du Bois, Haley, Heim, Taylor A, Mudianto, Tenny, Steele, Maria M, Nolz, Jeffrey C, Lund, Amanda W

“…Lymphatic vessels are often considered passive conduits that flush antigenic material, pathogens, and cells to draining lymph nodes. Recent evidence, however,…”
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Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease by Spinelli, Kateri J, Taylor, Jonathan K, Osterberg, Valerie R, Churchill, Madeline J, Pollock, Eden, Moore, Cynthia, Meshul, Charles K, Unni, Vivek K

“…Parkinson's disease and dementia with Lewy bodies are associated with abnormal neuronal aggregation of α-synuclein. However, the mechanisms of aggregation and…”
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Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter by Bentea, Eduard, Villers, Agnès, Moore, Cynthia, Funk, Adam J., O’Donovan, Sinead M., Verbruggen, Lise, Lara, Olaya, Janssen, Pauline, De Pauw, Laura, Declerck, Noemi B., DePasquale, Erica A. K., Churchill, Madeline J., Sato, Hideyo, Hermans, Emmanuel, Arckens, Lutgarde, Meshul, Charles K., Ris, Laurence, McCullumsmith, Robert E., Massie, Ann

“…The astrocytic cystine/glutamate antiporter system x c − represents an important source of extracellular glutamate in the central nervous system, with…”
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PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection by Oyesola, Oyebola O, Shanahan, Michael T, Kanke, Matt, Mooney, Bridget M, Webb, Lauren M, Smita, Shuchi, Matheson, Macy K, Campioli, Pamela, Pham, Duc, Früh, Simon P, McGinty, John W, Churchill, Madeline J, Cahoon, Jordan L, Sundaravaradan, Pavithra, Flitter, Becca A, Mouli, Karthik, Nadjsombati, Marija S, Kamynina, Elena, Peng, Seth A, Cubitt, Rebecca L, Gronert, Karsten, Lord, James D, Rauch, Isabella, von Moltke, Jakob, Sethupathy, Praveen, Tait Wojno, Elia D

“…Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth…”
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MPTP-induced parkinsonism in mice alters striatal and nigral xCT expression but is unaffected by the genetic loss of xCT by Bentea, Eduard, Sconce, Michelle D., Churchill, Madeline J., Van Liefferinge, Joeri, Sato, Hideyo, Meshul, Charles K., Massie, Ann

“…•MPTP treatment increases levels of xCT in the striatum.•MPTP treatment decreases levels of xCT in the substantia nigra.•Mice lacking xCT are equally sensitive…”
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Epithelial Pyroptosis in Host Defense by Churchill, Madeline J., Mitchell, Patrick S., Rauch, Isabella

“…[Display omitted] •Epithelial cells undergo inflammasome mediated-pyroptosis.•Intestinal epithelial cells extrude upon inflammasome activation.•We discuss…”
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Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson’s Disease by Massaquoi, Michelle S., Liguore, William A., Churchill, Madeline J., Moore, Cindy, Melrose, Heather L., Meshul, Charles K.

“…•DHF causes motor and striatal TH recovery in a progressive MPTP animal model of PD.•DHF induced motor recovery is not facilitated by restoration of dopamine…”
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Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease by Churchill, Madeline J., Cantu, Mark A., Kasanga, Ella A., Moore, Cindy, Salvatore, Michael F., Meshul, Charles K.

“…Parkinson's disease (PD) is the second most common neurodegenerative disease and there are no effective treatments that either slow or reverse the degeneration…”
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Dietary therapy restores glutamatergic input to orexin/hypocretin neurons after traumatic brain injury in mice by Elliott, Jonathan E, De Luche, Samuel E, Churchill, Madeline J, Moore, Cindy, Cohen, Akiva S, Meshul, Charles K, Lim, Miranda M

“…Abstract Study Objectives In previous work, dietary branched-chain amino acid (BCAA) supplementation, precursors to de novo glutamate and γ-aminobutyric acid…”
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Plastic changes at corticostriatal synapses predict improved motor function in a partial lesion model of Parkinson's disease by Bentea, Eduard, Moore, Cynthia, Deneyer, Lauren, Verbruggen, Lise, Churchill, Madeline J, Hood, Rebecca L, Meshul, Charles K, Massie, Ann

“…Highlights • Lactacystin leads to a partial loss of nigral cells and deficits in the rotarod task. • Lactacystin increases the length and area of the…”
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Lymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodes by Heim, Taylor A, Schultz, Austin C, Delclaux, Ines, Cristaldi, Vanessa, Churchill, Madeline J, Ventre, Katherine S, Lund, Amanda W

“…Lymphatic transport shapes the homeostatic immune repertoire of lymph nodes (LNs). LN-resident memory T cells (T ) play an important role in site-specific…”
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors by Steele, Maria M, Churchill, Madeline J, Breazeale, Alec P, Lane, Ryan S, Nelson, Nicholas A, Lund, Amanda W

“…Leukocyte egress from peripheral tissues to draining lymph nodes is not only critical for immune surveillance and initiation but also contributes to the…”
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Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease by Tamburrino, Anna, Churchill, Madeline J, Wan, Oi W, Colino-Sanguino, Yolanda, Ippolito, Rossana, Bergstrand, Sofie, Wolf, Daniel A, Herz, Niculin J, Sconce, Michelle D, Björklund, Anders, Meshul, Charles K, Decressac, Mickael

“…The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases)…”
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NAIP—NLRC4 inflammasome activation in tuft cells contributes to host defense against bacteria by Churchill, Madeline J, Rauch, Isabella

“…Abstract The small intestinal epithelium is exposed to various microbes, and intestinal epithelial cells (IECs) have developed an array of host defense…”
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The contributions of NAIP/NLRC4 inflammasome activation in Tuft cells to host barrier defense and immunity by Churchill, Madeline J, Rauch, Isabella

“…Abstract The small intestine is a key interface between host cells and potentially pathogenic agents, and as such has developed an array of host defense…”
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12.3 SYSTEM XC- AS A NOVEL MODULATOR OF CORTICOSTRIATAL NEUROTRANSMISSION by Bentea, Eduard, Moore, Cynthia, Villers, Agnès, Churchill, Madeline J, Hood, Rebecca L, Deneyer, Lauren, Verbruggen, Lise, Albertini, Giulia, Sato, Hideyo, Ris, Laurence, Meshul, Charles K, Massie, Ann

“…Abstract Background System xc- is a plasma membrane amino acid antiporter, of mainly glial origin, that couples the import of cystine with the export of…”
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