Search Results - "Church, Kathleen"

Five-Year Extension Results of the Phase 1 START Trial of Onasemnogene Abeparvovec in Spinal Muscular Atrophy by Mendell, Jerry R, Al-Zaidy, Samiah A, Lehman, Kelly J, McColly, Markus, Lowes, Linda P, Alfano, Lindsay N, Reash, Natalie F, Iammarino, Megan A, Church, Kathleen R, Kleyn, Aaron, Meriggioli, Matthew N, Shell, Richard

“…This ongoing study assesses long-term safety and durability of response in infants with spinal muscular atrophy (SMA) type 1 after dosing with onasemnogene…”
Get more information

Territoriality modifies the effects of habitat complexity on animal behavior: a meta-analysis by Church, Kathleen D W, Matte, Jean-Michel, Grant, James W A

“…Abstract Augmenting habitat complexity by adding structure has been used to increase the population density of some territorial species in the wild and to…”
Get full text

Does increasing habitat complexity favour particular personality types of juvenile Atlantic salmon, Salmo salar? by Church, Kathleen D.W., Grant, James W.A.

“…The costs and benefits of a particular behavioural trait, such as boldness or aggression, may vary depending on the physical environment. We tested whether the…”
Get full text

Ideal despotic distributions in convict cichlids (Amatitlania nigrofasciata)? Effects of predation risk and personality on habitat preference by Church, Kathleen D.W., Grant, James W.A.

“…•Dominant fish preferred structurally complex versus open habitats.•Subordinate fish, but not dominants, altered habitat use in response to predation…”
Get full text

Effects of habitat complexity, dominance and personality on habitat selection: Ideal despotic cichlids by Church, Kathleen D. W., Grant, James W. A., Wright, Jonathan

“…Habitat structure can impede visibility and movement, resulting in lower resource monopolization and aggression. Consequently, dominant individuals may prefer…”
Get full text

Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomes by Mendell, Jerry R., Sahenk, Zarife, Al-Zaidy, Samiah, Rodino-Klapac, Louise R., Lowes, Linda P., Alfano, Lindsay N., Berry, Katherine, Miller, Natalie, Yalvac, Mehmet, Dvorchik, Igor, Moore-Clingenpeel, Melissa, Flanigan, Kevin M., Church, Kathleen, Shontz, Kim, Curry, Choumpree, Lewis, Sarah, McColly, Markus, Hogan, Mark J., Kaspar, Brian K.

“…Sporadic inclusion body myositis, a variant of inflammatory myopathy, has features distinct from polymyositis/dermatomyositis. The disease affects men more…”
Get full text

AVXS-101 (Onasemnogene Abeparvovec) for SMA1: Comparative Study with a Prospective Natural History Cohort by Al-Zaidy, Samiah A, Kolb, Stephen J, Lowes, Linda, Alfano, Lindsay N, Shell, Richard, Church, Kathleen R, Nagendran, Sukumar, Sproule, Douglas M, Feltner, Douglas E, Wells, Courtney, Ogrinc, Francis, Menier, Melissa, L'Italien, James, Arnold, W David, Kissel, John T, Kaspar, Brian K, Mendell, Jerry R

“…Spinal muscular atrophy type 1 (SMA1) is the leading genetic cause of infant mortality for which therapies, including AVXS-101 (onasemnogene abeparvovec,…”
Get more information

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy by Mendell, Jerry R., Al-Zaidy, Samiah, Shell, Richard, Arnold, W. Dave, Rodino-Klapac, Louise R., Prior, Thomas W., Lowes, Linda, Alfano, Lindsay, Berry, Katherine, Church, Kathleen, Kissel, John T., Nagendran, Sukumar, L’Italien, James, Sproule, Douglas M., Wells, Courtney, Cardenas, Jessica A., Heitzer, Marjet D., Kaspar, Allan, Corcoran, Sarah, Braun, Lyndsey, Likhite, Shibi, Miranda, Carlos, Meyer, Kathrin, Foust, K.D., Burghes, Arthur H.M., Kaspar, Brian K.

Get full text

Evaluating potential effects of solar power facilities on wildlife from an animal behavior perspective by Chock, Rachel Y., Clucas, Barbara, Peterson, Elizabeth K., Blackwell, Bradley F., Blumstein, Daniel T., Church, Kathleen, Fernández‐Juricic, Esteban, Francescoli, Gabriel, Greggor, Alison L., Kemp, Paul, Pinho, Gabriela M., Sanzenbacher, Peter M., Schulte, Bruce A., Toni, Pauline

“…Solar power is a renewable energy source with great potential to help meet increasing global energy demands and reduce our reliance on fossil fuels. However,…”
Get full text

P314: Long-term safety and sustained functional benefit in patients with DMD 4 years post-treatment with delandistrogene moxeparvovec: A phase 1/2a study by O’Rourke, Erin, Mendell, Jerry R., Sahenk, Zarife, Lehman, Kelly J., Lowes, Linda P., Reash, Natalie F., Iammarino, Megan, Alfano, Lindsay, Lewis, Sarah, Church, Kathleen, Shell, Richard, Potter, Rachael A., Griffin, Danielle, Hogan, Mark J., Wang, Shufang, Mason, Stefanie, Darton, Eddie, Rodino-Klapac, Louise

Get full text

A Novel Method of Genomic DNA Extraction for Cactaceae by Fehlberg, Shannon D, Allen, Jessica M, Church, Kathleen

“…Premise of the study: Genetic studies of Cactaceae can at times be impeded by difficult sampling logistics and/or high mucilage content in tissues. Simplifying…”
Get full text

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial by Mendell, Jerry R, Sahenk, Zarife, Lehman, Kelly, Nease, Carrie, Lowes, Linda P, Miller, Natalie F, Iammarino, Megan A, Alfano, Lindsay N, Nicholl, Amanda, Al-Zaidy, Samiah, Lewis, Sarah, Church, Kathleen, Shell, Richard, Cripe, Linda H, Potter, Rachael A, Griffin, Danielle A, Pozsgai, Eric, Dugar, Ashish, Hogan, Mark, Rodino-Klapac, Louise R

“…Micro-dystrophin gene transfer shows promise for treating patients with Duchenne muscular dystrophy (DMD) using recombinant adeno-associated virus serotype…”
Get more information

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy by Mendell, Jerry R, Al-Zaidy, Samiah, Shell, Richard, Arnold, W. Dave, Rodino-Klapac, Louise R, Prior, Thomas W, Lowes, Linda, Alfano, Lindsay, Berry, Katherine, Church, Kathleen, Kissel, John T, Nagendran, Sukumar, L’Italien, James, Sproule, Douglas M, Wells, Courtney, Cardenas, Jessica A, Heitzer, Marjet D, Kaspar, Allan, Corcoran, Sarah, Braun, Lyndsey, Likhite, Shibi, Miranda, Carlos, Meyer, Kathrin, Foust, K.D, Burghes, Arthur H.M, Kaspar, Brian K

“…Fifteen children with spinal muscular atrophy type 1 received gene-replacement therapy with a single dose of adeno-associated virus containing SMN. In marked…”
Get full text

Impact of Age and Motor Function in a Phase 1/2A Study of Infants With SMA Type 1 Receiving Single-Dose Gene Replacement Therapy by Lowes, Linda P., Alfano, Lindsay N., Arnold, W. David, Shell, Richard, Prior, Thomas W., McColly, Markus, Lehman, Kelly J., Church, Kathleen, Sproule, Douglas M., Nagendran, Sukumar, Menier, Melissa, Feltner, Douglas E., Wells, Courtney, Kissel, John T., Al-Zaidy, Samiah, Mendell, Jerry

“…This study characterizes motor function responses after early dosing of AVXS-101 (onasemnogene abeparvovec) in gene replacement therapy in infants with severe…”
Get full text

Health outcomes in spinal muscular atrophy type 1 following AVXS‐101 gene replacement therapy by Al‐Zaidy, Samiah, Pickard, A. Simon, Kotha, Kavitha, Alfano, Lindsay N., Lowes, Linda, Paul, Grace, Church, Kathleen, Lehman, Kelly, Sproule, Douglas M., Dabbous, Omar, Maru, Benit, Berry, Katherine, Arnold, W. David, Kissel, John T., Mendell, Jerry R., Shell, Richard

“…Background Spinal Muscular Atrophy type 1 (SMA1) is a rare genetic neuromuscular disease where 75% of SMA1 patients die/require permanent‐ventilation by 13.6…”
Get full text

Aggressive interactions between two invasive species: the round goby (Neogobius melanostomus) and the spinycheek crayfish (Orconectes limosus) by Church, Kathleen, Iacarella, Josephine C., Ricciardi, Anthony

“…The invasion success of introduced species may be limited by competitive interactions with phylogenetically unrelated invaders. The round goby ( Neogobius…”
Get full text

260  Gene transfer with rAAVrh74.MHCK7.SGCB increased β-sarcoglycan expression in LGMD type 2E patients by Richardson, James, Rodino-Klapac, Louise, Pozsgai, Eric, Lewis, Sarah, Griffin, Danielle, Lehman, Kelly, Church, Kathleen, Miller, Natalie, Iammarino, Megan, Lowes, Linda, Mendell, Jerry

“…These are initial findings of ongoing, phase 1 multiple ascending-dose gene transfer trial of ≤9 LGMD2E patients who received rAAVrh74.MHCK7.SGCB…”
Get full text

130  Safety, β-sarcoglycan expression and functional outcomes from systemic gene transfer of rAAVrh74.MHCK7.SGCB in LGMD2E/R4 by Rodino-Klapac, Louise, Pozsgai, Eric, Lewis, Sarah, Griffin, Danielle, Meadows, Aaron, Lehman, Kelly, Church, Kathleen, Lowes, Linda, Richardson, James, Mendell, Jerry

“…Limb-girdle muscular dystrophy type 2E/R4 (LGMD2E/R4) is caused by β-sarcoglycan (SGCB) gene mutations, resulting in loss of functional protein and…”
Get full text

Long‐term safety and functional outcomes of delandistrogene moxeparvovec gene therapy in patients with Duchenne muscular dystrophy: A phase 1/2a nonrandomized trial by Mendell, Jerry R., Sahenk, Zarife, Lehman, Kelly J., Lowes, Linda P., Reash, Natalie F., Iammarino, Megan A., Alfano, Lindsay N., Lewis, Sarah, Church, Kathleen, Shell, Richard, Potter, Rachael A., Griffin, Danielle A., Hogan, Mark, Wang, Shufang, Mason, Stefanie, Darton, Eddie, Rodino‐Klapac, Louise R.

“…Introduction/Aims Delandistrogene moxeparvovec is indicated in the United States for the treatment of ambulatory pediatric patients aged 4 through 5 years with…”
Get full text

Long-term Safety and Efficacy in Patients with DMD 4 Years Post-Treatment with Delandistrogene Moxeparvovec (SRP-9001) in a Phase 1/2a Study (P3-8.006) by Mendell, Jerry, Sahenk, Zarife, Lehman, Kelly, Lowes, Linda, Reash, Natalie, Iammarino, Megan, Alfano, Lindsay, Lewis, Sarah, Church, Kathleen, Shell, Richard, Potter, Rachael, Griffin, Danielle, Hogan, Mark, Wang, Shufang, Mason, Stefanie, Darton, Eddie, Rodino-Klapac, Louise

“…Abstract only…”
Get full text