Search Results - "Church, Dawn"

Expression of spermidine/spermine N(1) -acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis by Huang, Wei, Eickhoff, Jens C, Mehraein-Ghomi, Farideh, Church, Dawn R, Wilding, George, Basu, Hirak S

“…Prostate cancer (PCa) in many patients remains indolent for the rest of their lives, but in some patients, it progresses to lethal metastatic disease. Gleason…”
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Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species by Huang, Sheng-Xiong, Bong-Sik Yun, Ming Ma, Hirak S. Basu, Dawn R. Church, Gudrun Ingenhorst, Yong Huang, Dong Yang, Jeremy R. Lohman, Gong-Li Tang, Jianhua Ju, Tao Liu, George Wilding, Ben Shen

“…Leinamycin (LNM) is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140, featuring an unusual 1,3-dioxo-1,2-dithiolane moiety that is…”
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Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo by Ewald, Jonathan A., Desotelle, Joshua A., Church, Dawn R., Yang, Bing, Huang, Wei, Laurila, Timo A., Jarrard, David F.

“…BACKGROUND The treatment of non‐localized prostate cancer involves androgen deprivation (AD) therapy which results in tumor regression. Apoptosis has been…”
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Protein kinase Cε interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer by AZIZ, Moammir H, MANOHARAN, Herbert T, CHURCH, Dawn R, DRECKSCHMIDT, Nancy E, WEIXIONG ZHONG, OBERLEY, Terry D, WILDING, George, VERMA, Ajit K

“…Abstract Prostate cancer is the most common type of cancer in men and ranks second only to lung cancer in cancer-related deaths. The management of locally…”
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Androgen Receptor Requires JunD as a Coactivator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells by MEHRAEIN-GHOMI, Farideh, BASU, Hirak S, CHURCH, Dawn R, HOFFMANN, F. Michael, WILDING, George

“…Relatively high oxidative stress levels in the prostate are postulated to be a major factor for prostate carcinogenesis and prostate cancer (CaP) progression…”
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Targeting androgen receptor and JunD interaction for prevention of prostate cancer progression by Mehraein-Ghomi, Farideh, Kegel, Stacy J., Church, Dawn R., Schmidt, Joseph S., Reuter, Quentin R., Saphner, Elizabeth L., Basu, Hirak S., Wilding, George

“…BACKGROUND Multiple studies show that reactive oxygen species (ROS) play a major role in prostate cancer (PCa) development and progression. Previously, we…”
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A Small Molecule Polyamine Oxidase Inhibitor Blocks Androgen-Induced Oxidative Stress and Delays Prostate Cancer Progression in the Transgenic Adenocarcinoma of the Mouse Prostate Model by BASU, Hirak S, THOMPSON, Todd A, CHURCH, Dawn R, CLOWER, Cynthia C, MEHRAEIN-GHOMI, Farideh, AMLONG, Corey A, MARTIN, Christopher T, WOSTER, Patrick M, LINDSTROM, Mary J, WILDING, George

“…High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence,…”
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Expression of spermidine/spermine N1-acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis by Huang, Wei, Eickhoff, Jens C., Mehraein-Ghomi, Farideh, Church, Dawn R., Wilding, George, Basu, Hirak S.

“…INTRODUCTION Prostate cancer (PCa) in many patients remains indolent for the rest of their lives, but in some patients, it progresses to lethal metastatic…”
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JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells by Mehraein-Ghomi, Farideh, Lee, Elyse, Church, Dawn R., Thompson, Todd A., Basu, Hirak S., Wilding, George

“…BACKGROUND Numerous and compelling evidence shows that high level of reactive oxygen species (ROS) plays a key role in prostate cancer occurrence, recurrence…”
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Inhibitor of p52 NF-κB subunit and androgen receptor (AR) interaction reduces growth of human prostate cancer cells by abrogating nuclear translocation of p52 and phosphorylated AR(ser81) by Mehraein-Ghomi, Farideh, Church, Dawn R, Schreiber, Cynthia L, Weichmann, Ashley M, Basu, Hirak S, Wilding, George

“…Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer,…”
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Growth inhibition and differentiation in human prostate carcinoma cells induced by the vitamin D analog 1α,24-dihydroxyvitamin D2 by Bauer, Joshua A., Thompson, Todd A., Church, Dawn R., Ariazi, Eric A., Wilding, George

“…Background Vitamin D has been suggested as a chemopreventive and therapeutic modality for prostate cancer. However, hypercalcemic toxicity has limited the use…”
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Induction of AP-1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells by Church, Dawn R., Lee, Elyse, Thompson, Todd A., Basu, Hirak S., Ripple, Maureen O., Ariazi, Eric A., Wilding, George

“…BACKGROUND The androgen receptor and activator protein‐1 (AP‐1) transcription factors affect growth regulation in normal and cancerous prostate cells. Effects…”
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Expression of spermidine/spermine N 1 ‐acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis by Huang, Wei, Eickhoff, Jens C., Mehraein‐Ghomi, Farideh, Church, Dawn R., Wilding, George, Basu, Hirak S.

“…INTRODUCTION Prostate cancer (PCa) in many patients remains indolent for the rest of their lives, but in some patients, it progresses to lethal metastatic…”
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Abstract 4968: “Moonlighting Functions” of glycolytic enzymes relate to human prostate cancer invasion by Yu, Jiaquan, Weichmann, Ashley M., Craig, Alexandria, Huang, Wei, Church, Dawn R., Mehraein, Farideh, Parker, Laurie L., Beebe, David J., Wilding, George, Basu, Hirak S.

“…Abstract Background: Castrate-resistant prostate cancer (CRPC) is the second leading cause of cancer deaths among US men. Currently, a large number of small…”
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Abstract 2899: Mitophagy imparts enzalutamide resistance in prostate cancer by Basu, Hirak S., Schrieber, Cynthia L., Sperger, Jamie M., Naundorf, Maryanne, Weichman, Ashley M., Mehraein-Ghomi, Farideh, Church, Dawn R., Lang, Joshua M., Wilding, George

“…Abstract Purpose: Anti-androgens are widely used in androgen deprivation therapy (ADT), a standard-of-care for patients with recurrent prostate cancer (PCa)…”
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Inhibitor of p52 NF-κB subunit and androgen receptor (AR) interaction reduces growth of human prostate cancer cells by abrogating nuclear translocation of p52 and phosphorylated ARser81 by Mehraein-Ghomi, Farideh, Church, Dawn R., Schreiber, Cynthia L., Weichmann, Ashley M., Basu, Hirak S., Wilding, George

“…Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer,…”
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Targeting androgen receptor and JunD interaction for prevention of prostate cancer progression: Inhibitors of AR-JunD Interaction in Prostate Cancer by Mehraein-Ghomi, Farideh, Kegel, Stacy J., Church, Dawn R., Schmidt, Joseph S., Reuter, Quentin R., Saphner, Elizabeth L., Basu, Hirak S., Wilding, George

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Abstract 2844: Inhibiting androgen receptor and JunD protein interaction to prevent prostate cancer progression by Schmidt, Joseph, Kegel, Stacy, Mehraein-Ghomi, Farideh, Saphner, Elizabeth, Reuter, Quentin, Church, Dawn, Hoffmann, F Michael, Basu, Hirak S., Wilding, George

“…Abstract Development of an effective therapy to prevent prostate cancer (PCa) progression to castrate-resistant PCa (CRPCa) remains an unmet medical need,…”
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Androgen Receptor Requires JunD as a Co-activator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells by Mehraein-Ghomi, Farideh, Basu, Hirak S., Church, Dawn R., Hoffmann, F. Michael, Wilding, George

“…Relatively high oxidative stress levels in the prostate are postulated to be a major factor for prostate carcinogenesis and prostate cancer (CaP) progression…”
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Abstract 2583: Targeting a novel pathway for prostate cancer therapy by Kegel, Stacy, Mehraein-Ghomi, Farideh, Reuter, Quentin, Schmidt, Joseph, Church, Dawn, Hoffmann, F. Michael, Basu, Hirak, Wilding, George

“…Abstract Development of an effective therapy to prevent prostate cancer (PCa) progression to castrate-resistant PCa (CRPCa) remains an unmet medical need,…”
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