Search Results - "Chuo Chen"

Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination by Xia, Ji-Bao, Zhu, Chen, Chen, Chuo

“…We report herein an operationally simple method for the direct conversion of benzylic C–H groups to C–F. We show that visible light can activate diarylketones…”
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cGAS is essential for the antitumor effect of immune checkpoint blockade by Wang, Hua, Hu, Shuiqing, Chen, Xiang, Shi, Heping, Chen, Chuo, Sun, Lijun, Chen, Zhijian J.

“…cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses. cGAS catalyzes the synthesis of cGAMP, which functions as a…”
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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA by Wu, Jiaxi, Sun, Lijun, Chen, Xiang, Du, Fenghe, Shi, Heping, Chen, Chuo, Chen, Zhijian J.

“…Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity. This DNA…”
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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING by Zhang, Xu, Shi, Heping, Wu, Jiaxi, Zhang, Xuewu, Sun, Lijun, Chen, Chuo, Chen, Zhijian J.

“…The presence of microbial or self DNA in the cytoplasm of mammalian cells is a danger signal detected by the DNA sensor cyclic-GMP-AMP (cGAMP) synthase (cGAS),…”
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Syntheses of cyclic guanidine-containing natural products by Ma, Yuyong, De, Saptarshi, Chen, Chuo

“…[Display omitted]…”
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Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING by Shi, Heping, Jiaxi Wu, Zhijian J. Chen, Chuo Chen

“…Cyclic GMP-AMP containing a unique combination of mixed phosphodiester linkages (2′3′-cGAMP) is an endogenous second messenger molecule that activates the…”
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Stromal–epithelial crosstalk regulates kidney progenitor cell differentiation by Das, Amrita, Tanigawa, Shunsuke, Karner, Courtney M., Xin, Mei, Lum, Lawrence, Chen, Chuo, Olson, Eric N., Perantoni, Alan O., Carroll, Thomas J.

“…Present models suggest that the fate of the kidney epithelial progenitors is solely regulated by signals from the adjacent ureteric bud. The bud provides…”
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An approach for the synthesis of nakamuric acid by Wang, Xiaolei, Chen, Chuo

“…The biosynthesis of dimeric pyrrole–imidazole alkaloids is likely mediated by enzyme-catalyzed reversible single-electron transfer (SET) cycloaddition. We now…”
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Synthesis and Structure Revision of Nakiterpiosin by Gao, Shuanhu, Wang, Qiaoling, Chen, Chuo

“…This manuscript describes a convergent synthesis and the revision of the relative stereochemistry of nakiterpiosin, a marine C-nor-D-homosteroid. Our synthesis…”
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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer by Lum, Lawrence, Chen, Baozhi, Dodge, Michael E, Tang, Wei, Lu, Jianming, Ma, Zhiqiang, Fan, Chih-Wei, Wei, Shuguang, Hao, Wayne, Kilgore, Jessica, Williams, Noelle S, Roth, Michael G, Amatruda, James F, Chen, Chuo

“…The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to identify small molecules that…”
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Asymmetric Synthesis of Axinellamines A and B by Ma, Zhiqiang, Wang, Xiao, Ma, Yuyong, Chen, Chuo

“…Axinellamines A and B are broad‐spectrum antibacterial pyrrole–imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these…”
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Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development by Karner, Courtney M, Das, Amrita, Ma, Zhendong, Self, Michelle, Chen, Chuo, Lum, Lawrence, Oliver, Guillermo, Carroll, Thomas J

“…The mammalian kidney is composed of thousands of individual epithelial tubules known as nephrons. Deficits in nephron number are associated with myriad…”
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Dimeric pyrrole-imidazole alkaloids: synthetic approaches and biosynthetic hypotheses by Wang, Xiao, Ma, Zhiqiang, Wang, Xiaolei, De, Saptarshi, Ma, Yuyong, Chen, Chuo

“…The pyrrole-imidazole alkaloids are a group of structurally unique and biologically interesting marine sponge metabolites. Among them, the cyclic dimers have…”
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Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence by Ma, Zhiqiang, Wang, Xiaolei, Wang, Xiao, Rodriguez, Rodrigo A., Moore, Curtis E., Gao, Shuanhu, Tan, Xianghui, Ma, Yuyong, Rheingold, Arnold L., Baran, Phil S., Chen, Chuo

“…Cycloaddition is an essential tool in chemical synthesis. Instead of using light or heat as a driving force, marine sponges promote cycloaddition with a more…”
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In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains by Moro, Enrico, Ozhan-Kizil, Gunes, Mongera, Alessandro, Beis, Dimitris, Wierzbicki, Claudia, Young, Rodrigo M., Bournele, Despina, Domenichini, Alice, Valdivia, Leonardo E., Lum, Lawrence, Chen, Chuo, Amatruda, James F., Tiso, Natascia, Weidinger, Gilbert, Argenton, Francesco

“…The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific cell signaling events during cell migration, differentiation and…”
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Ketone-catalyzed photochemical C(sp3)–H chlorination by Han, Lei, Xia, Ji-Bao, You, Lin, Chen, Chuo

“…Photoexcited arylketones catalyze the direct chlorination of C(sp3)–H groups by N- chlorosuccinimide. Acetophenone is the most effective catalyst for…”
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An Approach to the Core Skeleton of Lancifodilactone F by Wang, Qiaoling, Chen, Chuo

“…Two cycloaddition reactions were utilized for the construction of the 5,6,7-tricyclic skeleton of lancifodilactone F and buxapentalactone. A [2+2] ketene…”
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Label-Free Detection of Small-Molecule-Protein Interactions by Using Nanowire Nanosensors by Wang, Wayne U., Chen, Chuo, Lin, Keng-hui, Fang, Ying, Lieber, Charles M., El-Sayed, Mostafa A.

“…Development of miniaturized devices that enable rapid and direct analysis of the specific binding of small molecules to proteins could be of substantial…”
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Natural Products as Inspiration for the Development of New Synthetic Methods by Ma, Zhiqiang, Chen, Chuo

“…Natural products have played an important role in shaping modern synthetic organic chemistry. In particular, their complex molecular skeletons have stimulated…”
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Palladium-Catalyzed C-H Arylation of 1,2,3-Triazoles by Zhang, Chengwei, You, Lin, Chen, Chuo

“…Palladium(II) acetate, in combination with triphenylphosphine, catalyzes direct arylation of 1,4-disubstituted 1,2,3-triazoles effectively. This C-H arylation…”
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