Amelioration of obesity-related biomarkers by Lactobacillus sakei CJLS03 in a high-fat diet-induced obese murine model

Recent progresses in clinical diagnostic analyses have demonstrated the decisive influence of host gut microbiota on the status of metabolic disorders. Short chain fatty acids (SCFAs) produced by gut microbiota, in particular, are considered as a key biomarker, both of communication between gut micr...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 6821
Main Authors:	Ji, Yosep, Park, Soyoung, Chung, Youngmee, Kim, Bobae, Park, Haryung, Huang, Eunchong, Jeong, Dahye, Jung, Hoe-Yune, Kim, Bongjoon, Hyun, Chang-Kee, Holzapfel, Wilhelm H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02-05-2019 Nature Publishing Group
Subjects:	38/22 38/77 45/47 631/326/2522 631/45 64/60 82/80 82/83 Adipocytes - metabolism Adipose Tissue - metabolism Animal models Animals Biomarkers Body weight Diet, High-Fat Digestive system Disease Models, Animal Fatty acids Fatty Acids, Volatile - metabolism Gastrointestinal Microbiome Gastrointestinal tract High fat diet Homeostasis Humanities and Social Sciences Intestinal microflora Intestine Lactobacillus sakei Metabolic disorders Metabolism Mice Mice, Obese Microbiota multidisciplinary Obesity Obesity - etiology Obesity - metabolism Probiotics Science Science (multidisciplinary) Weight Gain
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Summary:	Recent progresses in clinical diagnostic analyses have demonstrated the decisive influence of host gut microbiota on the status of metabolic disorders. Short chain fatty acids (SCFAs) produced by gut microbiota, in particular, are considered as a key biomarker, both of communication between gut microbiota and the host, and of impact on host metabolic homeostasis. Microbiota modulation and concomitant anti-obesity effects of probiotics have been reported by different researchers. However, the underlying modulatory functions of probiotics on gut microbiota towards host metabolic homeostasis are still not fully understood. In this study, the impact of Lactobacillus sakei CJLS03 (isolated from Korean kimchi) on obesity-related biomarkers was investigated using a diet-induced obese mouse model. Body weight increase, SCFAs, the gut microbiota and various obesity-associated biomarkers were significantly and beneficially influenced by L. sakei CJLS03 administration compared to the control groups. Analytical data on faecal samples support the role of the colonic microbial population in SCFA production. The composition of the latter may be influenced by modulation of the distal gastro-intestinal microbiota by putative probiotics such as L. sakei CJLS03.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-43092-y