Search Results - "Chung, Stephen S M"

Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood–brain barrier breakdown after transient ischemia with long-term reperfusion by Zhang, Xu, Yeung, Patrick K.K., McAlonan, Grainne M., Chung, Stephen S.M., Chung, Sookja K.

“…[Display omitted] • TET-1 mice showed increased anxiety after transient MCAO with 7days reperfusion. • TET-1 mice showed cognitive deficit after transient MCAO…”
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Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity by Huang, Weifeng, Liu, Huili, Wang, Tao, Zhang, Tiantian, Kuang, Juntao, Luo, Yu, Chung, Stephen S.M, Yuan, Li, Yang, James Y

“…Osmotic response element binding protein (OREBP) is a Rel-like transcription factor critical for cellular osmoresponses. Previous studies suggest that…”
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Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress by Tong, Edith H Y, Guo, Jin-Jun, Xu, Song-Xiao, Mak, Keri, Chung, Sookja K, Chung, Stephen S M, Huang, Ali-Long, Ko, Ben C B

“…Osmotic Response Element-Binding Protein (OREBP), also known as TonEBP or NFAT5, is a unique transcription factor. It is hitherto the only known mammalian…”
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Diabetic cataracts: mechanisms and management by Obrosova, Irina G., Chung, Stephen S. M., Kador, Peter F.

“…Diabetes mellitus is associated with a 5‐fold higher prevalence of cataracts, which remains a major cause of blindness in the world. Typical diabetic cataracts…”
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Deletion of aldose reductase leads to protection against cerebral ischemic injury by Lo, Amy CY, Cheung, Alvin KH, Hung, Victor KL, Yeung, Chung-Man, He, Qing-Yu, Chiu, Jen-Fu, Chung, Stephen SM, Chung, Sookja K

“…Previously, we reported that transgenic mice overexpressing endothelin-1 in astrocytes showed more severe neurological deficits and increased infarct after…”
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Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage by Yeung, Patrick K K, Shen, Jiangang, Chung, Stephen S M, Chung, Sookja K

“…Endothelin-1 (ET-1) is a potent vasoconstrictor, and astrocytic ET-1 is reported to play a role in the pathogenesis of cerebral ischemic injury and cytotoxic…”
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Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina by Cheung, Simon S F, Leung, Justin W C, Lam, Amy K M, Lam, Karen S L, Chung, Stephen S M, Lo, Amy C Y, Chung, Sookja K

“…The level of endothelin-1 (ET-1), a potent vasoconstrictor, was associated with retinopathy under ischemia. The effects of endothelial endothelin-1 (ET-1)…”
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Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves by Chau, Jenny F. L, Lee, M. K, Law, Janice W. S, Chung, Sookja K, Chung, Stephen S. M

“…ABSTRACTSodium/myo‐inositol cotransporter‐1 (SMIT‐1) is one of the transporters responsible for importing myo‐inositol (MI) into the cells. MI is a precursor…”
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Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet by Lo, Amy CY, Chen, Ann YS, Hung, Victor KL, Yaw, Lai Ping, Fung, Maggie KL, Ho, Maggie CY, Tsang, Margaret CS, Chung, Stephen SM, Chung, Sookja K

“…Stroke patients have increased levels of endothelin-1 (ET-1), a strong vasoconstrictor, in their plasma or cerebrospinal fluid. Previously, we showed high…”
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Regulation of Nucleocytoplasmic Trafficking of Transcription Factor OREBP/TonEBP/NFAT5 by Tong, Edith H.Y., Guo, Jin-Jun, Huang, Ai-Long, Liu, Han, Hu, Chang-Deng, Chung, Stephen S.M., Ko, Ben C.B.

“…The osmotic response element-binding protein (OREBP), also known as tonicity enhancer-binding protein (TonEBP) or NFAT5, regulates the hypertonicity-induced…”
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Phosphorylation by Casein Kinase 1 Regulates Tonicity-induced Osmotic Response Element-binding Protein/Tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking by Xu, SongXiao, Wong, Catherine C.L., Tong, Edith H.Y., Chung, Stephen S.M., Yates, John R., Yin, YiBing, Ko, Ben C.B.

“…The osmotic response element-binding protein (OREBP), also known as tonicity enhancer-binding protein (TonEBP) or NFAT5, is the only known osmo-sensitive…”
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Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson’s disease by Yeung, Patrick KK, Lai, Angela KW, Son, Hyo Jin, Zhang, Xu, Hwang, Onyou, Chung, Stephen SM, Chung, Sookja K

“…Abstract Fungicide exposure causes degeneration of dopaminergic neurons and contributes to Parkinson’s disease (PD). Benomyl inhibits enzymes responsible for…”
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Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism by Yang, James Y, Tam, W Y, Tam, Sidney, Guo, Hong, Wu, Xiaochun, Li, Guohua, Chau, Jenny F L, Klein, Janet D, Chung, Sookja K, Sands, Jeff M, Chung, Stephen S M

“…To investigate the underlying causes for aldose reductase deficiency-induced diabetes insipidus, we carried out studies with three genotypic groups of mice…”
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Selective Astrocytic Endothelin-1 Overexpression Contributes to Dementia Associated with Ischemic Stroke by Exaggerating Astrocyte-Derived Amyloid Secretion by Hung, Victor KL, Yeung, Patrick KK, Lai, Angela KW, Ho, Maggie CY, Lo, Amy CY, Chan, Kevin C, Wu, Ed XK, Chung, Stephen SM, Cheung, Chi W, Chung, Sookja K

“…Endothelin-1 (ET-1) is synthesized by endothelial cells and astrocytes in stroke and in brains of Alzheimer's disease patients. Our transgenic mice with ET-1…”
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Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion by Leung, Justin W.C, Chung, Stephen S.M, Chung, Sookja K

“…Abstract Endothelin-1 (ET-1) is up-regulated in the endothelial cells and astrocytes under ischemia. Transgenic mice with astrocytic ET-1 over-expression…”
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Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice by CHEUNG, Alvin K. H, FUNG, Maggie K. L, LO, Amy C. Y, LAM, Terence T. L, KWOK FAI SO, CHUNG, Stephen S. M, CHUNG, Sookja K

“…Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice Alvin K.H…”
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Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo by WONG, Vincent K. W, CHIU, Pauline, CHUNG, Stephen S. M, CHOW, Larry M. C, ZHAO, Yun-Zhe, YANG, Burton B, KO, Ben C. B

“…Purpose: Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi that has been used as an antifungal remedy in…”
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Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow by Li, Gui‐Rong, Deng, Xiu‐Ling, Sun, Haiying, Chung, Stephen S.M., Tse, Hung‐Fat, Lau, Chu‐Pak

“…Mesenchymal stem cells (MSCs) from bone marrow are believed to be an ideal cell source for cardiomyoplasty; however, cellular electrophysiology is not…”
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Aldose Reductase Regulates Hepatic Peroxisome Proliferator-activated Receptor α Phosphorylation and Activity to Impact Lipid Homeostasis by Qiu, Longxin, Wu, Xiaochun, Chau, Jenny F.L., Szeto, Irene Y.Y., Tam, Wing Yip, Guo, Zongsheng, Chung, Sookja K., Oates, Peter J., Chung, Stephen S.M., Yang, James Y.

“…Aldose reductase (AR) is implicated in the development of a number of diabetic complications, but the underlying mechanisms remain to be fully elucidated. We…”
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More severe type 2 diabetes-associated ischemic stroke injury is alleviated in aldose reductase-deficient mice by Yeung, Chung-Man, Lo, Amy C.Y., Cheung, Alvin K.H., Chung, Stephen S.M., Wong, David, Chung, Sookja K.

“…Aldose reductase (AR), the first enzyme in the polyol pathway, has been implicated in a wide variety of physiological and pathological functions, such as…”
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