Search Results - "Chung, Kyoung‐Jin"

Innate immune cells in the adipose tissue by Chung, Kyoung-Jin, Nati, Marina, Chavakis, Triantafyllos, Chatzigeorgiou, Antonios

“…Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including…”
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The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease by Nati, Marina, Chung, Kyoung-Jin, Chavakis, Triantafyllos

“…Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and is linked to obesity and related conditions, such as the…”
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DEL-1 promotes macrophage efferocytosis and clearance of inflammation by Kourtzelis, Ioannis, Li, Xiaofei, Mitroulis, Ioannis, Grosser, Daniel, Kajikawa, Tetsuhiro, Wang, Baomei, Grzybek, Michal, von Renesse, Janusz, Czogalla, Aleksander, Troullinaki, Maria, Ferreira, Anaisa, Doreth, Christian, Ruppova, Klara, Chen, Lan-Sun, Hosur, Kavita, Lim, Jong-Hyung, Chung, Kyoung-Jin, Grossklaus, Sylvia, Tausche, Anne Kathrin, Joosten, Leo A. B., Moutsopoulos, Niki M., Wielockx, Ben, Castrillo, Antonio, Korostoff, Jonathan M., Coskun, Ünal, Hajishengallis, George, Chavakis, Triantafyllos

“…Resolution of inflammation is essential for tissue homeostasis and represents a promising approach to inflammatory disorders. Here we found that developmental…”
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Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis by Troullinaki, Maria, Alexaki, Vasileia‐Ismini, Mitroulis, Ioannis, Witt, Anke, Klotzsche–von Ameln, Anne, Chung, Kyoung‐Jin, Chavakis, Triantafyllos, Economopoulou, Matina

“…The mechanism underlying vasoproliferative retinopathies like retinopathy of prematurity (ROP) is hypoxia‐triggered neovascularisation. Nerve growth factor…”
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A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity by Chung, Kyoung-Jin, Chatzigeorgiou, Antonios, Economopoulou, Matina, Garcia-Martin, Ruben, Alexaki, Vasileia I, Mitroulis, Ioannis, Nati, Marina, Gebler, Janine, Ziemssen, Tjalf, Goelz, Susan E, Phieler, Julia, Lim, Jong-Hyung, Karalis, Katia P, Papayannopoulou, Thalia, Blüher, Matthias, Hajishengallis, George, Chavakis, Triantafyllos

“…Obesity is commonly accompanied by inflammatory responses in white adipose tissues. Chavakis and colleagues identify a vicious cycle involving α 4 integrins…”
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The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss by Eskan, Mehmet A, Jotwani, Ravi, Abe, Toshiharu, Chmelar, Jindrich, Lim, Jong-Hyung, Liang, Shuang, Ciero, Paul A, Krauss, Jennifer L, Li, Fenge, Rauner, Martina, Hofbauer, Lorenz C, Choi, Eun Young, Chung, Kyoung-Jin, Hashim, Ahmed, Curtis, Michael A, Chavakis, Triantafyllos, Hajishengallis, George

“…Periodontitis is associated with aging and more neutrophil-mediated tissue pathology. Hajishengallis and colleagues show an inverse correlation between…”
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Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice by Chung, Kyoung-Jin, Legaki, Aigli-Ioanna, Papadopoulos, Grigorios, Gercken, Bettina, Gebler, Janine, Schwabe, Robert F, Chavakis, Triantafyllos, Chatzigeorgiou, Antonios

“…Non-alcoholic fatty liver disease (NAFLD) can progress to non-alcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis. Fibrosis is…”
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The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance by Chmelar, Jindrich, Chung, Kyoung-Jin, Chavakis, Triantafyllos

“…Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose…”
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Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance by Caratti, Giorgio, Stifel, Ulrich, Caratti, Bozhena, Jamil, Ali J. M., Chung, Kyoung-Jin, Kiehntopf, Michael, Gräler, Markus H., Blüher, Matthias, Rauch, Alexander, Tuckermann, Jan P.

“…Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven inflammation of adipose tissue. Whether anti-inflammatory…”
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The RNA binding protein human antigen R is a gatekeeper of liver homeostasis by Subramanian, Pallavi, Gargani, Sofia, Palladini, Alessandra, Chatzimike, Margarita, Grzybek, Michal, Peitzsch, Mirko, Papanastasiou, Anastasios D., Pyrina, Iryna, Ntafis, Vasileios, Gercken, Bettina, Lesche, Mathias, Petzold, Andreas, Sinha, Anupam, Nati, Marina, Thangapandi, Veera Raghavan, Kourtzelis, Ioannis, Andreadou, Margarita, Witt, Anke, Dahl, Andreas, Burkhardt, Ralph, Haase, Robert, Domingues, António Miguel de Jesus, Henry, Ian, Zamboni, Nicola, Mirtschink, Peter, Chung, Kyoung‐Jin, Hampe, Jochen, Coskun, Ünal, Kontoyiannis, Dimitris L., Chavakis, Triantafyllos

“…Background and Aims NAFLD is initiated by steatosis and can progress through fibrosis and cirrhosis to HCC. The RNA binding protein human antigen R (HuR)…”
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DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1 by Ziogas, Athanasios, Maekawa, Tomoki, Wiessner, Johannes R, Le, Thi Trang, Sprott, David, Troullinaki, Maria, Neuwirth, Ales, Anastasopoulou, Vasiliki, Grossklaus, Sylvia, Chung, Kyoung-Jin, Sperandio, Markus, Chavakis, Triantafyllos, Hajishengallis, George, Alexaki, Vasileia Ismini

“…Leukocytes are rapidly recruited to sites of inflammation via interactions with the vascular endothelium. The steroid hormone dehydroepiandrosterone (DHEA)…”
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Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Langer, Harald F, Choi, Eun Young, Zhou, Hong, Schleicher, Rebecca, Chung, Kyoung-Jin, Tang, Zhongshu, Göbel, Kerstin, Bdeir, Khalil, Chatzigeorgiou, Antonios, Wong, Connie, Bhatia, Sumeena, Kruhlak, Michael J, Rose, John W, Burns, James B, Hill, Kenneth E, Qu, Hongchang, Zhang, Yongqing, Lehrmann, Elin, Becker, Kevin G, Wang, Yunmei, Simon, Daniel I, Nieswandt, Bernhard, Lambris, John D, Li, Xuri, Meuth, Sven G, Kubes, Paul, Chavakis, Triantafyllos

“…RATIONALE:Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous…”
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The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance by Phieler, Julia, Chung, Kyoung-Jin, Chatzigeorgiou, Antonios, Klotzsche-von Ameln, Anne, Garcia-Martin, Ruben, Sprott, David, Moisidou, Maria, Tzanavari, Theodora, Ludwig, Barbara, Baraban, Elena, Ehrhart-Bornstein, Monika, Bornstein, Stefan R, Mziaut, Hassan, Solimena, Michele, Karalis, Katia P, Economopoulou, Matina, Lambris, John D, Chavakis, Triantafyllos

“…Obese adipose tissue (AT) inflammation contributes critically to development of insulin resistance. The complement anaphylatoxin C5a receptor (C5aR) has been…”
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Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis by Langer, Harald F., Chung, Kyoung-Jin, Orlova, Valeria V., Choi, Eun Young, Kaul, Sunil, Kruhlak, Michael J., Alatsatianos, Markella, DeAngelis, Robert A., Roche, Paul A., Magotti, Paola, Li, Xuri, Economopoulou, Matina, Rafail, Stavros, Lambris, John D., Chavakis, Triantafyllos

“…Beyond its role in immunity, complement mediates a wide range of functions in the context of morphogenetic or tissue remodeling processes. Angiogenesis is…”
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Dual role of B7 costimulation in obesity‐related nonalcoholic steatohepatitis and metabolic dysregulation by Chatzigeorgiou, Antonios, Chung, Kyoung‐Jin, Garcia‐Martin, Ruben, Alexaki, Vasileia‐Ismini, Klotzsche‐von Ameln, Anne, Phieler, Julia, Sprott, David, Kanczkowski, Waldemar, Tzanavari, Theodora, Bdeir, Mohktar, Bergmann, Sibylle, Cartellieri, Marc, Bachmann, Michael, Nikolakopoulou, Polyxeni, Androutsellis‐Theotokis, Andreas, Siegert, Gabriele, Bornstein, Stefan R., Muders, Michael H., Boon, Louis, Karalis, Katia P., Lutgens, Esther, Chavakis, Triantafyllos

“…The low‐grade inflammatory state present in obesity contributes to obesity‐related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and…”
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No Role for Mast Cells in Obesity-Related Metabolic Dysregulation by Chmelař, Jindřich, Chatzigeorgiou, Antonios, Chung, Kyoung-Jin, Prucnal, Marta, Voehringer, David, Roers, Axel, Chavakis, Triantafyllos

“…Obesity-related adipose tissue (AT) inflammation that promotes metabolic dysregulation is associated with increased AT mast cell numbers. Mast cells are potent…”
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Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation by Pyrina, Iryna, Chung, Kyoung-Jin, Michailidou, Zoi, Koutsilieris, Michael, Chavakis, Triantafyllos, Chatzigeorgiou, Antonios

“…Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells,…”
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Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades by Sun, Hu-Nan, Kim, Sun-Uk, Huang, Song Mei, Kim, Jin-Man, Park, Young-Ho, Kim, Seok-Ho, Yang, Hee-Young, Chung, Kyoung-Jin, Lee, Tae-Hoon, Choi, Hoon Sung, Min, Ju Sik, Park, Moon-Ki, Kim, Sang-Keun, Lee, Sang-Rae, Chang, Kyu-Tae, Lee, Sang-Ho, Yu, Dae-Yeul, Lee, Dong-Seok

“…J. Neurochem. (2010) 114, 39-50. Reactive oxygen species (ROS) actively participate in microglia-mediated pathogenesis as pro-inflammatory molecules. However,…”
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RtxA1-Induced Expression of the Small GTPase Rac2 Plays a Key Role in the Pathogenicity of Vibrio vulnificus by Chung, Kyoung-Jin, Cho, Eun-Jin, Kim, Mi Kwang, Kim, Young Ran, Kim, Seok-Ho, Yang, Hee-Young, Chung, Ki-Chul, Lee, Shee Eun, Rhee, Joon Haeng, Choy, Hyon E., Lee, Tae-Hoon

“…Infection with the human pathogen Vibrio vulnificus leads to the generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In the…”
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Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity by Kalafati, Lydia, Kourtzelis, Ioannis, Schulte-Schrepping, Jonas, Li, Xiaofei, Hatzioannou, Aikaterini, Grinenko, Tatyana, Hagag, Eman, Sinha, Anupam, Has, Canan, Dietz, Sevina, de Jesus Domingues, Antonio Miguel, Nati, Marina, Sormendi, Sundary, Neuwirth, Ales, Chatzigeorgiou, Antonios, Ziogas, Athanasios, Lesche, Mathias, Dahl, Andreas, Henry, Ian, Subramanian, Pallavi, Wielockx, Ben, Murray, Peter, Mirtschink, Peter, Chung, Kyoung-Jin, Schultze, Joachim L., Netea, Mihai G., Hajishengallis, George, Verginis, Panayotis, Mitroulis, Ioannis, Chavakis, Triantafyllos

“…Trained innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates sustained increased responsiveness to…”
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