Search Results - "Chung, Kenny K.K"

S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function by Kenny K. K. Chung, Thomas, Bobby, Li, Xiaojie, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, Dawson, Valina L., Dawson, Ted M.

“…Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important in the survival of dopamine neurons in Parkinson's disease (PD)…”
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S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease by Tsang, Anthony H.K, Lee, Yun-IL, Ko, Han Seok, Savitt, Joseph M, Pletnikova, Olga, Troncoso, Juan C, Dawson, Valina L, Dawson, Ted M, Chung, Kenny K.K

“…Inhibitors of apoptosis (IAPs) are a family of highly-conserved proteins that regulate cell survival through binding to caspases, the final executioners of…”
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Parkin ubiquitinates the α-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease by Dawson, Ted M, Chung, Kenny K.K, Zhang, Yi, Lim, Kah Leong, Tanaka, Yuji, Huang, Hui, Gao, Jun, Ross, Christopher A, Dawson, Valina L

“…Parkinson disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated…”
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Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin by Sriram, Sathya R., Li, Xiaojie, Ko, Han Seok, Chung, Kenny K.K., Wong, Esther, Lim, Kah Leong, Dawson, Valina L., Dawson, Ted M.

“…Mutations in parkin are largely associated with autosomal recessive juvenile parkinsonism. The underlying mechanism of pathogenesis in parkin-associated…”
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role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease by Lee, Francesca K.M, Wong, Azaria K.Y, Lee, Yuk Wa, Wan, Oi Wan, Edwin Chan, H.Y, Chung, Kenny K.K

“…Parkinson's disease (PD) is a common movement disorder marked by the loss of dopaminergic (DA) neurons in the brain stem and the presence of intraneuronal…”
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NO Parkin in Parkinson's Disease by Lancaster, Jack R., Kenny K. K. Chung, Dawson, Valina L., Dawson, Ted M.

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The role of age‐associated alpha‐synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation by Li, Jiahua, Ng, Ka Wai, Sung, Chun Chau, Chung, Kenny K. K.

“…Parkinson's disease (PD) is a common neurodegenerative disorder that is affecting an increasing number of older adults. Although PD is mostly sporadic, genetic…”
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Oxidative and nitrosative stress in Parkinson's disease by Tsang, Anthony H.K., Chung, Kenny K.K.

“…Parkinson's disease (PD) is a common neurodegenerative disorder marked by movement impairment caused by a selective degeneration of dopaminergic neurons. The…”
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Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease by Xie, Weilin, Chung, Kenny K. K.

“…J. Neurochem. (2012) 122, 404–414. Alpha‐synuclein (α‐syn) is a synaptic protein that mutations have been linked to Parkinson’s disease (PD), a common…”
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Novel enhancement mechanism of tyrosine hydroxylase enzymatic activity by nitric oxide through S-nitrosylation by Wang, Yuanyuan, Sung, Chun Chau, Chung, Kenny K. K.

“…Tyrosine hydroxylase (TH) is a rate-limiting step enzyme in the synthesis of catecholamines. Catecholamines function both as hormone and neurotransmitters in…”
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S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease by Wu, Weiwei, Sung, Chun Chau, Yu, Peichun, Li, Jiahua, Chung, Kenny K K

“…Parkinson's disease (PD) is a common neurodegenerative disorder which is mostly sporadic but familial-linked PD (FPD) cases have also been found. The first…”
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The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease by Wan, Oi Wan, Chung, Kenny K K

“…α-Synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene triplication) have been found to cause an autosomal dominant form…”
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New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease by Xie, Weilin, Wan, Oi Wan, Chung, Kenny K.K.

“…Parkinson's disease (PD) is a common neurodegenerative movement disorder that affects increasing number of elderly in the world population. The disease is…”
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S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP’s anti-caspase 3 activity and anti-apoptotic function by Wu, Weiwei, Wan, Oi Wan, Chung, Kenny K. K.

“…X-linked inhibitor of apoptosis (XIAP) is a protein that possesses anti-apoptotic function and dysregulation of it has been linked to a number human disease…”
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Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation by Lim, Kah Leong, Chew, Katherine C. M, Tan, Jeanne M. M, Wang, Cheng, Chung, Kenny K. K, Zhang, Yi, Tanaka, Yuji, Smith, Wanli, Engelender, Simone, Ross, Christopher A, Dawson, Valina L, Dawson, Ted M

“…It is widely accepted that the familial Parkinson's disease (PD)-linked gene product, parkin, functions as a ubiquitin ligase involved in protein turnover via…”
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Parkin Functions as an E2-Dependent Ubiquitin-Protein Ligase and Promotes the Degradation of the Synaptic Vesicle-Associated Protein, CDCrel-1 by Zhang, Yi, Gao, Jun, Kenny K. K. Chung, Huang, Hui, Dawson, Valina L., Dawson, Ted M.

“…Parkinson's disease is a common neurodegenerative disorder in which familial-linked genes have provided novel insights into the pathogenesis of this disorder…”
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Emerging roles of nitric oxide in neurodegeneration by Chung, Kenny K.K., David, Karen K.

“…Nitric oxide (NO) is a gaseous signaling molecule which has physiological and pathological roles in the cell. Under normal conditions, NO is produced by nitric…”
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Accumulation of the Authentic Parkin Substrate Aminoacyl-tRNA Synthetase Cofactor, p38/JTV-1, Leads to Catecholaminergic Cell Death by Ko, Han Seok, von Coelln, Rainer, Sriram, Sathya R, Kim, Seong Who, Chung, Kenny K. K, Pletnikova, Olga, Troncoso, Juan, Johnson, Brett, Saffary, Roya, Goh, Eyleen L, Song, Hongjun, Park, Bum-Joon, Kim, Min Jung, Kim, Sunghoon, Dawson, Valina L, Dawson, Ted M

“…Autosomal-recessive juvenile parkinsonism (AR-JP) is caused by loss-of-function mutations of the parkin gene. Parkin, a RING-type E3 ubiquitin ligase, is…”
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The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders by Chung, Kenny K.K, Dawson, Valina L, Dawson, Ted M

“…A unifying feature of neurodegenerative diseases is the abnormal accumulation and processing of mutant or damaged intra- and extracellular proteins; this leads…”
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Studying nitrosative stress in Parkinson's disease by Chung, Kenny K K

“…Parkinson's disease (PD) is marked by a selective degeneration of dopaminergic neurons in the brain stem and it is the second most common neurodegenerative…”
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