Search Results - "Chung, Kathryn"

Fludrocortisone for orthostatic hypotension by Veazie, Stephanie, Peterson, Kim, Ansari, Yasmin, Chung, Kathryn A, Gibbons, Christopher H, Raj, Satish R, Helfand, Mark

“…Orthostatic hypotension is an excessive fall in blood pressure (BP) while standing and is the result of a decrease in cardiac output or defective or inadequate…”
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Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease by CHUNG, Kathryn A, LOBB, Brenna M, NUTT, John G, HORAK, Fay B

“…To investigate if a central cholinesterase inhibitor will reduce falling frequency in subjects with Parkinson disease (PD) with advanced postural instability…”
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Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression by Shi, Min, Bradner, Joshua, Hancock, Aneeka M., Chung, Kathryn A., Quinn, Joseph F., Peskind, Elaine R., Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P., Kim, Hojoong M., Leverenz, James B., Montine, Thomas J., Ginghina, Carmen, Kang, Un Jung, Cain, Kevin C., Wang, Yu, Aasly, Jan, Goldstein, David, Zhang, Jing

“…Objective: There is a clear need to develop biomarkers for Parkinson disease (PD) diagnosis, differential diagnosis of Parkinsonian disorders, and monitoring…”
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Gastrointestinal dysfunction in the synucleinopathies by Chung, Kathryn A., Pfeiffer, Ronald F.

“…Interest in gastrointestinal dysfunction in Parkinson’s disease has blossomed over the past 30 years and has generated a wealth of investigation into this…”
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Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease by Davis, Marie Y, Johnson, Catherine O, Leverenz, James B, Weintraub, Daniel, Trojanowski, John Q, Chen-Plotkin, Alice, Van Deerlin, Vivianna M, Quinn, Joseph F, Chung, Kathryn A, Peterson-Hiller, Amie L, Rosenthal, Liana S, Dawson, Ted M, Albert, Marilyn S, Goldman, Jennifer G, Stebbins, Glenn T, Bernard, Bryan, Wszolek, Zbigniew K, Ross, Owen A, Dickson, Dennis W, Eidelberg, David, Mattis, Paul J, Niethammer, Martin, Yearout, Dora, Hu, Shu-Ching, Cholerton, Brenna A, Smith, Megan, Mata, Ignacio F, Montine, Thomas J, Edwards, Karen L, Zabetian, Cyrus P

“…Parkinson disease (PD) is heterogeneous in symptom manifestation and rate of progression. Identifying factors that influence disease progression could provide…”
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DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease by Hong, Zhen, Shi, Min, Chung, Kathryn A., Quinn, Joseph F., Peskind, Elaine R., Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P., Leverenz, James B., Baird, Geoffrey, Montine, Thomas J., Hancock, Aneeka M., Hwang, Hyejin, Pan, Catherine, Bradner, Joshua, Kang, Un J., Jensen, Poul H., Zhang, Jing

“…Biomarkers are urgently needed for the diagnosis and monitoring of disease progression in Parkinson’s disease. Both DJ-1 and α-synuclein, two proteins…”
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GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease by Mata, Ignacio F., Leverenz, James B., Weintraub, Daniel, Trojanowski, John Q., Chen-Plotkin, Alice, Van Deerlin, Vivianna M., Ritz, Beate, Rausch, Rebecca, Factor, Stewart A., Wood-Siverio, Cathy, Quinn, Joseph F., Chung, Kathryn A., Peterson-Hiller, Amie L., Goldman, Jennifer G., Stebbins, Glenn T., Bernard, Bryan, Espay, Alberto J., Revilla, Fredy J., Devoto, Johnna, Rosenthal, Liana S., Dawson, Ted M., Albert, Marilyn S., Tsuang, Debby, Huston, Haley, Yearout, Dora, Hu, Shu-Ching, Cholerton, Brenna A., Montine, Thomas J., Edwards, Karen L., Zabetian, Cyrus P.

“…ABSTRACT Background Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is…”
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APOE ε4 increases risk for dementia in pure synucleinopathies by Tsuang, Debby, Leverenz, James B, Lopez, Oscar L, Hamilton, Ronald L, Bennett, David A, Schneider, Julie A, Buchman, Aron S, Larson, Eric B, Crane, Paul K, Kaye, Jeffrey A, Kramer, Patricia, Woltjer, Randy, Trojanowski, John Q, Weintraub, Daniel, Chen-Plotkin, Alice S, Irwin, David J, Rick, Jacqueline, Schellenberg, Gerard D, Watson, G Stennis, Kukull, Walter, Nelson, Peter T, Jicha, Gregory A, Neltner, Janna H, Galasko, Doug, Masliah, Eliezer, Quinn, Joseph F, Chung, Kathryn A, Yearout, Dora, Mata, Ignacio F, Wan, Jia Y, Edwards, Karen L, Montine, Thomas J, Zabetian, Cyrus P

“…To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy. Genetic case-control association study. Academic…”
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Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease by Cholerton, Brenna, Johnson, Catherine O., Fish, Brian, Quinn, Joseph F., Chung, Kathryn A., Peterson-Hiller, Amie L., Rosenthal, Liana S., Dawson, Ted M., Albert, Marilyn S., Hu, Shu-Ching, Mata, Ignacio F., Leverenz, James B., Poston, Kathleen L., Montine, Thomas J., Zabetian, Cyrus P., Edwards, Karen L.

“…Identification of factors associated with progression of cognitive symptoms in Parkinson's disease (PD) is important for treatment planning, clinical care, and…”
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A Metabolomic Aging Clock Using Human Cerebrospinal Fluid by Hwangbo, Nathan, Zhang, Xinyu, Raftery, Daniel, Gu, Haiwei, Hu, Shu-Ching, Montine, Thomas J, Quinn, Joseph F, Chung, Kathryn A, Hiller, Amie L, Wang, Dongfang, Fei, Qiang, Bettcher, Lisa, Zabetian, Cyrus P, Peskind, Elaine, Li, Gail, Promislow, Daniel E L, Franks, Alexander

“…Abstract Quantifying the physiology of aging is essential for improving our understanding of age-related disease and the heterogeneity of healthy aging. Recent…”
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APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease by Mata, Ignacio F, Leverenz, James B, Weintraub, Daniel, Trojanowski, John Q, Hurtig, Howard I, Van Deerlin, Vivianna M, Ritz, Beate, Rausch, Rebecca, Rhodes, Shannon L, Factor, Stewart A, Wood-Siverio, Cathy, Quinn, Joseph F, Chung, Kathryn A, Peterson, Amie L, Espay, Alberto J, Revilla, Fredy J, Devoto, Johnna, Hu, Shu-Ching, Cholerton, Brenna A, Wan, Jia Y, Montine, Thomas J, Edwards, Karen L, Zabetian, Cyrus P

“…Cognitive impairment is a common and disabling problem in Parkinson disease (PD) that is not well understood and is difficult to treat. Identification of…”
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Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease by Shi, Min, Zabetian, Cyrus P., Hancock, Aneeka M., Ginghina, Carmen, Hong, Zhen, Yearout, Dora, Chung, Kathryn A., Quinn, Joseph F., Peskind, Elaine R., Galasko, Douglas, Jankovic, Joseph, Leverenz, James B., Zhang, Jing

“…DJ-1 and α-synuclein are leading biomarkers for Parkinson's disease diagnosis and/or monitoring disease progression. A few recent investigations have…”
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Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease by Morris, Rosie, Martini, Douglas N., Smulders, Katrijn, Kelly, Valerie E., Zabetian, Cyrus P., Poston, Kathleen, Hiller, Amie, Chung, Kathryn A., Yang, Laurice, Hu, Shu-Ching, Edwards, Karen L., Cholerton, Brenna, Grabowski, Thomas J., Montine, Thomas J., Quinn, Joseph F., Horak, Fay

“…Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and…”
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Phosphorylated α-synuclein in Parkinson's disease by Wang, Yu, Shi, Min, Chung, Kathryn A, Zabetian, Cyrus P, Leverenz, James B, Berg, Daniela, Srulijes, Karin, Trojanowski, John Q, Lee, Virginia M-Y, Siderowf, Andrew D, Hurtig, Howard, Litvan, Irene, Schiess, Mya C, Peskind, Elaine R, Masuda, Masami, Hasegawa, Masato, Lin, Xiangmin, Pan, Catherine, Galasko, Douglas, Goldstein, David S, Jensen, Poul Henning, Yang, Hui, Cain, Kevin C, Zhang, Jing

“…Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human…”
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CSF Aβ42 and tau in Parkinson's disease with cognitive impairment by Montine, Thomas J., Shi, Min, Quinn, Joseph F., Peskind, Elaine R., Craft, Suzanne, Ginghina, Carmen, Chung, Kathryn A., Kim, Hojoong, Galasko, Douglas R., Jankovic, Joseph, Zabetian, Cyrus P., Leverenz, James B., Zhang, Jing

“…We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's…”
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CSF Multianalyte Profile Distinguishes Alzheimer and Parkinson Diseases by JING ZHANG, SOKAL, Izabela, PESKIND, Elaine R, QUINN, Joseph F, JANKOVIC, Joseph, KENNEY, Christopher, CHUNG, Kathryn A, MILLARD, Steven P, NUTT, John G, MONTINE, Thomas J

“…The therapeutic imperative for Alzheimer disease (AD) and Parkinson disease (PD) calls for discovery and validation of biomarkers. Increased cerebrospinal…”
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CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment by Montine, Thomas J, Shi, Min, Quinn, Joseph F, Peskind, Elaine R, Craft, Suzanne, Ginghina, Carmen, Chung, Kathryn A, Kim, Hojoong, Galasko, Douglas R, Jankovic, Joseph, Zabetian, Cyrus P, Leverenz, James B, Zhang, Jing

“…We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's…”
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Homocysteine and cognitive function in Parkinson's disease by Licking, Nicole, Murchison, Charles, Cholerton, Brenna, Zabetian, Cyrus P., Hu, Shu-Ching, Montine, Thomas J., Peterson-Hiller, Amie L., Chung, Kathryn A., Edwards, Karen, Leverenz, James B., Quinn, Joseph F.

“…Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear…”
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Evaluation of mild cognitive impairment subtypes in Parkinson's disease by Cholerton, Brenna A., Zabetian, Cyrus P., Wan, Jia Y., Montine, Thomas J., Quinn, Joseph F., Mata, Ignacio F., Chung, Kathryn A., Peterson, Amie, Espay, Alberto J., Revilla, Fredy J., Devoto, Johnna, Watson, G. Stennis, Hu, Shu-Ching, Leverenz, James B., Edwards, Karen L.

“…ABSTRACT Mild cognitive impairment in Parkinson's disease (PD‐MCI) is common and increases the risk for dementia. Establishing distinct PD‐MCI cognitive…”
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Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy by Wang, Yu, Hancock, Aneeka M, Bradner, Joshua, Chung, Kathryn A, Quinn, Joseph F, Peskind, Elaine R, Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P, Kim, Hojoong M, Leverenz, James B, Montine, Thomas J, Ginghina, Carmen, Edwards, Karen L, Snapinn, Katherine W, Goldstein, David S, Shi, Min, Zhang, Jing

“…Complement activation, a key component of neuroinflammation, has been reported in both Parkinson's disease (PD) and Alzheimer's disease (AD). However, it is…”
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