Search Results - "Chung, Jay H."

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway by Kim, Jeonghan, Kim, Ho-Shik, Chung, Jay H.

“…In addition to constituting the genetic material of an organism, DNA is a tracer for the recognition of foreign pathogens and a trigger of the innate immune…”
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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases by Park, Sung-Jun, Ahmad, Faiyaz, Philp, Andrew, Baar, Keith, Williams, Tishan, Luo, Haibin, Ke, Hengming, Rehmann, Holger, Taussig, Ronald, Brown, Alexandra L., Kim, Myung K., Beaven, Michael A., Burgin, Alex B., Manganiello, Vincent, Chung, Jay H.

“…Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is…”
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Metabolic effects of resveratrol: addressing the controversies by Bitterman, Jacob L, Chung, Jay H

“…Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful…”
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VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease by Kim, Jeonghan, Gupta, Rajeev, Blanco, Luz P, Yang, Shutong, Shteinfer-Kuzmine, Anna, Wang, Kening, Zhu, Jun, Yoon, Hee Eun, Wang, Xinghao, Kerkhofs, Martijn, Kang, Hyeog, Brown, Alexandra L, Park, Sung-Jun, Xu, Xihui, Zandee van Rilland, Eddy, Kim, Myung K, Cohen, Jeffrey I, Kaplan, Mariana J, Shoshan-Barmatz, Varda, Chung, Jay H

“…Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane…”
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AMP-Activated Protein Kinase―Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol by UM, Jee-Hyun, PARK, Sung-Jun, KANG, Hyeog, SHUTONG YANG, FORETZ, Marc, MCBURNEY, Michael W, KIM, Myung K, VIOLLET, Benoit, CHUNG, Jay H

“…Resveratrol, a natural polyphenolic compound that is found in grapes and red wine, increases metabolic rate, insulin sensitivity, mitochondrial biogenesis, and…”
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Peptide Switch Is Essential for Sirt1 Deacetylase Activity by Kang, Hyeog, Suh, Jeong-Yong, Jung, Young-Sang, Jung, Jae-Won, Kim, Myung K., Chung, Jay H.

“…In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1 –7) with a conserved deacetylase core that utilizes NAD + as a cofactor. Interestingly,…”
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AMPK regulates circadian rhythms in a tissue- and isoform-specific manner by Um, Jee-Hyun, Pendergast, Julie S, Springer, Danielle A, Foretz, Marc, Viollet, Benoit, Brown, Alexandra, Kim, Myung K, Yamazaki, Shin, Chung, Jay H

“…AMP protein kinase (AMPK) plays an important role in food intake and energy metabolism, which are synchronized to the light-dark cycle. In vitro, AMPK affects…”
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The Role of mPer2 Clock Gene in Glucocorticoid and Feeding Rhythms by Yang, Shutong, Liu, Aiyi, Weidenhammer, Adam, Cooksey, Robert C, McClain, Donald, Kim, Myung K, Aguilera, Greti, Abel, E. Dale, Chung, Jay H

“…The circadian clock synchronizes the activity level of an organism to the light-dark cycle of the environment. Energy intake, as well as energy metabolism,…”
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CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage by Kang, Hyeog, Jung, Jae-Won, Kim, Myung K, Chung, Jay H

“…SIRT1, an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells from stress-induced apoptosis, and its orthologues delay aging in…”
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The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest by Atkins, Katelyn M., Thomas, Laura L., Barroso-González, Jonathan, Thomas, Laurel, Auclair, Sylvain, Yin, Jun, Kang, Hyeog, Chung, Jay H., Dikeakos, Jimmy D., Thomas, Gary

“…SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here, we demonstrate that the sorting protein…”
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Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis by Park, Sung-Jun, Ahmad, Faiyaz, Bahde, Robert J, Philp, Andrew, Kim, Jeonghan, Huang, Tianjiao, Kim, Myung K, Trenkle, William C, Chung, Jay H

“…AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including…”
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Computational Modeling and Imaging of the Intracellular Oxygen Gradient by Sedlack, Andrew J. H., Penjweini, Rozhin, Link, Katie A., Brown, Alexandra, Kim, Jeonghan, Park, Sung-Jun, Chung, Jay H., Morgan, Nicole Y., Knutson, Jay R.

“…Computational modeling can provide a mechanistic and quantitative framework for describing intracellular spatial heterogeneity of solutes such as oxygen…”
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Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function by Muo, Ijeoma M., Park, Sung-Jun, Smith, Antoine, A. Springer, Danielle, Allen, Michele D., Hagen, Timothy J., Chung, Jay H.

“…Therapies that recapitulate the health benefits of caloric restriction in older adults are needed. Phosphodiesterase 4 inhibitors demonstrate such promise. We…”
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Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis by Park, Jun Hong, Kang, Hong-Jun, Lee, Yun Kyung, Kang, Hyeog, Kim, Jihyun, Chung, Jay H., Chang, Ji Suk, McPherron, Alexandra C., Lee, Sean Bong

“…EWS (Ewing sarcoma) encodes an RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosomal translocations…”
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Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins by Kang, Hyeog, Oka, Shinichi, Lee, Duck-Yeon, Park, Junhong, Aponte, Angel M., Jung, Young-Sang, Bitterman, Jacob, Zhai, Peiyong, He, Yi, Kooshapur, Hamed, Ghirlando, Rodolfo, Tjandra, Nico, Lee, Sean B., Kim, Myung K., Sadoshima, Junichi, Chung, Jay H.

“…Sirt1 is an NAD + -dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and…”
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Electrospun Microfibers Modulate Intracellular Amino Acids in Liver Cells via Integrin β1 by Huang, Tianjiao, Terrell, John A., Chung, Jay H., Chen, Chengpeng

“…Although numerous recent studies have shown the importance of polymeric microfibrous extracellular matrices (ECMs) in maintaining cell behaviors and functions,…”
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The role of DNA‐PK in aging and energy metabolism by Chung, Jay H.

“…DNA‐dependent protein kinase (DNA‐PK) is a very large holoenzyme comprised of the p470 kDa DNA‐PK catalytic subunit (DNA‐PKcs) and the Ku heterodimer…”
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Metabolic benefits of inhibiting cAMP-PDEs with resveratrol by Chung, Jay H.

“…Calorie restriction (CR) extends lifespan in species ranging from yeast to mammals. There is evidence that CR also protects against aging-related diseases in…”
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Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair by Zhang, Junran, Willers, Henning, Feng, Zhihui, Ghosh, Jagadish C., Kim, Sang, Weaver, David T., Chung, Jay H., Powell, Simon N., Xia, Fen

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK by Park, Sung-Jun, Ahmad, Faiyaz, Um, Jee-Hyun, Brown, Alexandra L., Xu, Xihui, Kang, Hyeog, Ke, Hengming, Feng, Xuesong, Ryall, James, Philp, Andrew, Schenk, Simon, Kim, Myung K., Sartorelli, Vittorio, Chung, Jay H.

“…The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does…”
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