Search Results - "Chung, Fuzon"

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia by Kiel, Mark J., Velusamy, Thirunavukkarasu, Rolland, Delphine, Sahasrabuddhe, Anagh A., Chung, Fuzon, Bailey, Nathanael G., Schrader, Alexandra, Li, Bo, Li, Jun Z., Ozel, Ayse B., Betz, Bryan L., Miranda, Roberto N., Medeiros, L. Jeffrey, Zhao, Lili, Herling, Marco, Lim, Megan S., Elenitoba-Johnson, Kojo S.J.

“…The comprehensive genetic alterations underlying the pathogenesis of T-cell prolymphocytic leukemia (T-PLL) are unknown. To address this, we performed…”
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Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome by Kiel, Mark J., Sahasrabuddhe, Anagh A., Rolland, Delphine C. M., Velusamy, Thirunavukkarasu, Chung, Fuzon, Schaller, Matthew, Bailey, Nathanael G., Betz, Bryan L., Miranda, Roberto N., Porcu, Pierluigi, Byrd, John C., Medeiros, L. Jeffrey, Kunkel, Steven L., Bahler, David W., Lim, Megan S., Elenitoba-Johnson, Kojo S. J.

“…Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and limited options for targeted therapies. The comprehensive genetic…”
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A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma by Sahasrabuddhe, Anagh Anant, Chen, Xiaofei, Ma, Kaiyu, Wu, Rui, Kapoor, Richa, Chhipa, Rishi Raj, Zhang, Xiao, Onder, Ozlem, Wilmore, Joel, Gaudette, Brian T., Pillai, Vinodh, Li, Marilyn M., Ahn, Joon-Young, Chung, Fuzon, Szankasi, Philippe, Basrur, Venkatesha, Conlon, Kevin P, Bailey, Nathanael G., Hogaboam, Cory M, Rottapel, Robert, Kim, Junhyong, Lopez, Cristina, Seufert, Julian, Schlesner, Matthias, Siebert, Reiner, Cancro, Michael P, Allman, David, Pagano, Michele, Staudt, Louis M., Lim, Megan S., Elenitoba-Johnson, Kojo S.J.

“…Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common form of malignant lymphoma and may arise de novo, or through transformation from a…”
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A Novel Non-Canonical Phosphodegron Regulates EZH2 Proteasomal Degradation and H3K27 Trimethylation Activity in Hematopoietic Malignancies by Sahasrabuddhe, Anagh A, Chen, Xiaofei, Velusamy, Thirunavukkarasu, Chung, Fuzon, Lim, Megan S, Elenitoba-Johnson, Kojo S.J.

“…Introduction: Enhancer of zeste homologue 2 (EZH2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2) which trimethylates histone H3…”
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SCF-β-TrCP E3 Ubiquitin Ligase-Mediated Proteolysis Of EZH2 Regulates H3K27 Trimethylation Activity In Germinal Center-Derived B-Cell Lymphomas by Sahasrabuddhe, Anagh A, Chen, Xiaofei, Chung, Fuzon, Velusamy, Thirunavukkarasu, Lim, Megan S, Elenitoba-Johnson, Kojo S.J.

“…EZH2 is a critical enzymatic subunit of the PRC2 which trimethylates histone H3 (H3K27) to mediate gene repression. While overexpression of EZH2 and its…”
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Integrated Genome Sequencing Reveals Frequent Loss of Function Alterations of ARID1A and Other Epigenetic Modifiers in Sezary Syndrome by Kiel, Mark, Sahasrabuddhe, Anagh A, Velusamy, Thiru, Chung, Fuzon, Bailey, Nathanael G., Betz, Bryan L, Bahler, David W, Miranda, Roberto N., Medeiros, L. Jeffrey, Lim, Megan S, Elenitoba-Johnson, Kojo S.J.

“…Introduction Sezary Syndrome (SS) is an aggressive mature T-cell neoplasm characterized by erythroderma, generalized lymphadenopathy and circulating T-cells…”
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SCFFbxo45 controls cytokinesis through ubiquitin‐mediated proteolysis of GEF‐H1 by chen, xiaofei, Ahn, Joon-Young, Szankasi, Philippe, Chung, Fuzon, Basrur, enkatesha, Lim, Megan S., Miller, Ann L., Pagano, Michele, Elenitoba-Johnson, Kojo S. J.

“…Abstract only The rho guanine nucleotide exchange factor H1 (GEF‐H1) is a critical regulator of cytokinesis, but the requirement and mechanism for its timely…”
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Gene mapping of mouse IL-4 receptor : the loci of interleukin 4 (IL-4) receptor gene and lymphocyte function associated antigen 1 (LFA-1) gene are closely linked on chromosome 7 by SUZUKI, H, CHUNG, F, PALMER, E, SASAKI, T, OHARA, N, TAYLOR, B. A, OHARA, J.-I

“…In the present study, we have investigated the chromosomal localization of the mIL-4R gene to obtain additional insight into IL-4 biology, in particular, for…”
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