Search Results - "Chung, Douglas"

Comparison of pre-operative computed tomography cholangiography and intraoperative cholangiography in laparoscopic cholecystectomy: a retrospective analysis by Chung, Douglas

“…The role of intra-operative cholangiography (IOC) in laparoscopic cholecystectomy (LC) is controversial. CT cholangiography (CTC) provides a reliable…”
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Innate lymphoid cells in early tumor development by Warner, Kathrin, Ghaedi, Maryam, Chung, Douglas C, Jacquelot, Nicolas, Ohashi, Pamela S

“…Innate and adaptive immune cells monitor, recognize, and eliminate transformed cells. Innate lymphoid cells (ILCs) are innate counterparts of T cells that play…”
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Mechanisms and determinants of ultralong action potential duration and slow rate-dependence in cardiac myocytes by Qu, Zhilin, Chung, Douglas

“…In normal cardiac myocytes, the action potential duration (APD) is several hundred milliseconds. However, experimental studies showed that under certain…”
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Innate Lymphoid Cells: Role in Immune Regulation and Cancer by Chung, Douglas C, Jacquelot, Nicolas, Ghaedi, Maryam, Warner, Kathrin, Ohashi, Pamela S

“…Immune regulation is composed of a complex network of cellular and molecular pathways that regulate the immune system and prevent tissue damage. It is…”
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Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models by Lamorte, Sara, Elford, Alisha R, Chung, Douglas C, Murakami, Kiichi, McGaha, Tracy L, Jacquelot, Nicolas

“…Pancreatic cancer remains an unmet medical need. Late diagnosis and the lack of efficient treatment significantly impact the prognosis of patients suffering…”
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A comparison of electronically-delivered and face to face cognitive behavioural therapies in depressive disorders: A systematic review and meta-analysis by Luo, Candice, Sanger, Nitika, Singhal, Nikhita, Pattrick, Kaitlin, Shams, Ieta, Shahid, Hamnah, Hoang, Peter, Schmidt, Joel, Lee, Janice, Haber, Sean, Puckering, Megan, Buchanan, Nicole, Lee, Patsy, Ng, Kim, Sun, Sunny, Kheyson, Sasha, Chung, Douglas Cho-Yan, Sanger, Stephanie, Thabane, Lehana, Samaan, Zainab

“…Cognitive behavioural therapy (CBT) is a widely used treatment for depression. However, limited resource availability poses several barriers to patients…”
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Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy by Jacquelot, Nicolas, Ghaedi, Maryam, Warner, Kathrin, Chung, Douglas C, Crome, Sarah Q, Ohashi, Pamela S

“…Immune checkpoints (IC) are broadly characterized as inhibitory pathways that tightly regulate the activation of the immune system. These molecular "brakes"…”
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Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization by Chung, Douglas C, Garcia-Batres, Carlos R, Millar, Douglas G, Wong, Stephanie W Y, Elford, Alisha R, Mathews, Jessica A, Wang, Ben X, Nguyen, Linh T, Shaw, Patricia A, Clarke, Blaise A, Bernardini, Marcus Q, Sacher, Adrian G, Crome, Sarah Q, Ohashi, Pamela S

“…NK cells have been shown to exhibit inflammatory and immunoregulatory functions in a variety of healthy and diseased settings. In the context of chronic viral…”
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A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability by Chung, Douglas, Bakshi, Suruchi, van der Graaf, Piet H

“…Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive quantitative mechanistic understanding of the effects of these and…”
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Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors by Chung, Douglas C, Ghaedi, Maryam, Warner, Kathrin, Sayad, Azin, Saibil, Samuel D, Bernardini, Marcus Q, Clarke, Blaise A, Shaw, Patricia A, Butler, Marcus O, Easson, Alexandra, Morrissy, Sorana, Wang, Ben X, Nguyen, Linh, Ohashi, Pamela S, Jacquelot, Nicolas

“…The innate lymphoid cell (ILC) family is composed of heterogeneous innate effector and helper immune cells that preferentially reside in tissues where they…”
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Chemotherapy-induced changes in tumor consistency can allow gross total resection of previously unresectable brainstem pilocytic astrocytoma by Chung, Douglas J., Arif, Bilal, Odia, Yazmin, Siomin, Vitaly

“…Background: Low-grade gliomas (LGG) are described by the World Health Organization as Grades I and II. Among LGGs, the most common primary brain tumor is…”
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Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells by Han, SeongJun, Chung, Douglas C., St. Paul, Michael, Liu, Zhe Qi, Garcia-Batres, Carlos, Elford, Alisha R., Tran, Charles W., Chapatte, Laurence, Ohashi, Pamela S.

“…Regulatory T cells are integral to the regulation of autoimmune and anti-tumor immune responses. However, several studies have suggested that changes in T cell…”
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Extreme Intracranial Hypotension With Brain Herniation Treated With Repeat Bolus Intrathecal Infusions by Chung, Douglas J, Liounakos, Jason, Abrams, Kevin, Siomin, Vitaly

“…Intracranial hypotension (IH) is a relatively common condition associated with low cerebrospinal (CSF) pressure. The most typical symptom is orthostatic…”
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Microsurgical Clip Suspension to Prevent Optic Neuropathy Following Ligation of Anterior Communicating Artery Aneurysm: A Technical Report and Surgical Video by Chung, Douglas J, Matus, Alejandro, Siomin, Vitaly

“…Anterior communicating artery (ACoA) aneurysms are among the most common intracerebral aneurysms. Complications of ACoA aneurysm include subarachnoid…”
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Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity by Han, SeongJun, Liu, Zhe Qi, Chung, Douglas C, Paul, Michael St, Garcia-Batres, Carlos R, Sayad, Azin, Elford, Alisha R, Gold, Matthew J, Grimshaw, Natasha, Ohashi, Pamela S

“…Regulatory T cells (Treg) are an integral component of the adaptive immune system that negatively affect antitumor immunity. Here, we investigated the role of…”
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Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy by St. Paul, Michael, Saibil, Samuel D., Kates, Meghan, Han, SeongJun, Lien, Scott C., Laister, Rob C., Hezaveh, Kebria, Kloetgen, Andreas, Penny, Susanne, Guo, Tingxi, Garcia-Batres, Carlos, Smith, Logan K., Chung, Douglas C., Elford, Alisha R., Sayad, Azin, Pinto, Devanand, Mak, Tak W., Hirano, Naoto, McGaha, Tracy, Ohashi, Pamela S.

“…The manipulation of T cell metabolism to enhance anti-tumor activity is an area of active investigation. Here, we report that activating the amino acid…”
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831 E3 ubiquitin ligase Cbl-b deficient CD8+ T cells overcome Treg cell-mediated suppression through IFN-γ and induce robust anti-tumor immunity by Han, SeongJun, Liu, Zhe Qi, Chung, Douglas, Paul, Michael St, Garcia-Batres, Carlos, Sayad, Azin, Elford, Alisha, Gold, Matthew, Grimshaw, Natasha, Ohashi, Pamela

“…BackgroundAdoptive T cell therapy (ACT) is reaching its potential in multiple malignancies. However, anti-tumor T cell responses can be attenuated by…”
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Jejunal diverticulosis - A case series and literature review by Chung, Douglas

“…Scant literature is available regarding in vivo jejunal diverticulosis, in part due to its typically asymptomatic course. This is made more difficult by the…”
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Jejunal diverticulitis secondary to a gastrointestinal stromal tumor: A case report by Chung, Douglas

“…The common manifestations of gastrointestinal stromal tumors (GIST) are well established. However, jejunal diverticulosis is an uncommon phenomenon to be…”
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Ischaemic gastritis and perforation by Chung, Douglas

“…Gastric perforation is a common general surgical emergency. Ischaemia of the stomach is uncommon due to its rich vascular supply, and is an uncommon cause of…”
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