Search Results - "Chung, D E"

Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer by Jiang, Zhe, Ju, YoungJun, Ali, Amjad, Chung, Philip E. D., Skowron, Patryk, Wang, Dong-Yu, Shrestha, Mariusz, Li, Huiqin, Liu, Jeff C., Vorobieva, Ioulia, Ghanbari-Azarnier, Ronak, Mwewa, Ethel, Koritzinsky, Marianne, Ben-David, Yaacov, Woodgett, James R., Perou, Charles M., Dupuy, Adam, Bader, Gary D., Egan, Sean E., Taylor, Michael D., Zacksenhaus, Eldad

“…Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary…”
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Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy by Chung, Philip E. D., Gendoo, Deena M. A., Ghanbari-Azarnier, Ronak, Liu, Jeff C., Jiang, Zhe, Tsui, Jennifer, Wang, Dong-Yu, Xiao, Xiao, Li, Bryan, Dubuc, Adrian, Shih, David, Remke, Marc, Ho, Ben, Garzia, Livia, Ben-David, Yaacov, Kang, Seok-Gu, Croul, Sidney, Haibe-Kains, Benjamin, Huang, Annie, Taylor, Michael D., Zacksenhaus, Eldad

“…Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1 . Presence of leptomeningeal metastases is…”
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A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride by Kaplan, S A, Chung, D E, Lee, R K, Scofield, S, Te, A E

“…We evaluated 5-year safety, efficacy and prostate volume data from BPH patients treated with finasteride or dutasteride. A retrospective analysis of 378…”
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Pre-Clinical Studies of a Novel Bispecific Fusion Protein Targeting C3b and VEGF in Neovascular and Nonexudative AMD Models by Lee, Yeri, Kim, Donggeon, Chung, Philip E. D., Lee, Minkyeong, Kim, Nahmju, Chang, Jihoon, Lee, Byoung Chul

“…Introduction KNP-301 is a bi-specific fragment crystallizable region (Fc) fusion protein, which inhibits both C3b and vascular endothelial growth factor (VEGF)…”
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Prodrugs of anthracyclines in cancer chemotherapy by Kratz, F, Warnecke, A, Schmid, B, Chung, D-E, Gitzel, M

“…Designing and developing truly tumor-specific prodrugs remains a challenge in the field of cancer chemotherapy. Active targeting strategies, on the one hand,…”
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shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer by TAO DENG, LIU, Jeff C, EGAN, Sean E, AL-AWAR, Rima, MOFFAT, Jason, ZACKSENHAUS, Eldad, CHUNG, Philip E. D, UEHLING, David, AMAN, Ahmed, JOSEPH, Babu, KETELA, Troy, ZHE JIANG, SCHACHTER, Nathan F, ROTTAPEL, Robert

“…HER2(+) breast cancer is currently treated with chemotherapy plus anti-HER2 inhibitors. Many patients do not respond or relapse with aggressive metastatic…”
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Novel racemosin B derivatives as new therapeutic agents for aggressive breast cancer by Xiao, Xiao, Xu, Mei, Yang, Chao, Yao, Yao, Liang, Li-na, ED Chung, Philip, Long, Qun, Zacksenhaus, Eldad, He, Zhixu, Liu, Sheng, Ben-David, Yaacov

“…[Display omitted] •New analogues of racemosin B were prepared and examined for anticancer activity.•The derivatives showed strong anti-cancer activity against…”
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A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux by Xiao, Xiao, Chung, Philip. E.D., Xu, Mei, Hu, Anling, Ju, Yangju, Yang, Xinmei, Song, Jialei, Song, Jingrui, Wang, Chunlin, Zacksenhaus, Eldad, Liu, Sheng, He, Zhixu, Ben-David, Yaacov

“…[Display omitted] Breast cancer is the most common malignancy among women worldwide. As conventional therapies are only partially successful in eradicating…”
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Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes by Jiang, Zhe, Li, Huiqin, Schroer, Stephanie A, Voisin, Veronique, Ju, YoungJun, Pacal, Marek, Erdmann, Natalie, Shi, Wei, Chung, Philip E D, Deng, Tao, Chen, Nien‐Jung, Ciavarra, Giovanni, Datti, Alessandro, Mak, Tak W, Harrington, Lea, Dick, Frederick A, Bader, Gary D, Bremner, Rod, Woo, Minna, Zacksenhaus, Eldad

“…Despite extensive analysis of pRB phosphorylation in vitro , how this modification influences development and homeostasis in vivo is unclear. Here, we show…”
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A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements by Idriss, Salam, Hallal, Mohammad, El-Kurdi, Abdullah, Zalzali, Hasan, El-Rassi, Inaam, Ehli, Erik A, Davis, Christel M, Chung, Philip E D, Gendoo, Deena M A, Zacksenhaus, Eldad, Saab, Raya, Khoueiry, Pierre

“…Pediatric pineoblastomas (PBs) are rare and aggressive tumors of grade IV histology. Although some oncogenic drivers are characterized, including germline…”
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Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis by Zacksenhaus, Eldad, Shrestha, Mariusz, Liu, Jeff C, Vorobieva, Ioulia, Chung, Philip E D, Ju, YoungJun, Nir, Uri, Jiang, Zhe

“…A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid cell duplication, and is driven by multiple oncogenic alterations,…”
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Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast by An, Yeji, Adams, Jessica R., Hollern, Daniel P., Zhao, Anthony, Chang, Stephen G., Gams, Miki S., Chung, Philip E.D., He, Xiaping, Jangra, Rhea, Shah, Juhi S., Yang, Joanna, Beck, Lauren A., Raghuram, Nandini, Kozma, Katelyn J., Loch, Amanda J., Wang, Wei, Fan, Cheng, Done, Susan J., Zacksenhaus, Eldad, Guidos, Cynthia J., Perou, Charles M., Egan, Sean E.

“…CDH1 and PIK3CA are the two most frequently mutated genes in invasive lobular carcinoma (ILC) of the breast. Transcription profiling has identified molecular…”
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Thinking (Metastasis) outside the (Primary Tumor) Box by Jiang, Zhe, Ju, Young-Jun, Ali, Amjad, Chung, Philip E. D., Wang, Dong-Yu, Liu, Jeff C., Li, Huiqin, Vorobieva, Ioulia, Mwewa, Ethel, Ghanbari-Azarnier, Ronak, Shrestha, Mariusz, Ben-David, Yaacov, Zacksenhaus, Eldad

“…The metastasis of tumor cells into vital organs is a major cause of death from diverse types of malignancies [...]…”
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RB1 and p53 at the crossroad of EMT and triple-negative breast cancer by Jiang, Zhe, Jones, Robert, Liu, Jeff C., Deng, Tao, Robinson, Tyler, Chung, Philip E.D., Wang, Sharon, Herschkowitz, Jason I., Egan, Sean E., Perou, Charles M., Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC) is a heterogeneous disease that includes Basal-like and Claudin-low tumors. The Claudin-low tumors are enriched for…”
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Methylation data of mouse Rb-deficient pineoblastoma by Chung, Philip E.D., Zacksenhaus, Eldad

“…Methylation profiling is widely used to study tumor biology and perform cluster analysis, particularly in brain cancer research where tissue biopsies are…”
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CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead by Zacksenhaus, Eldad, Liu, Jeff C., Granieri, Letizia, Vorobieva, Ioulia, Wang, Dong-Yu, Ghanbari-Azarnier, Ronak, Li, Huiqin, Ali, Amjad, Chung, Philip E.D., Ju, YoungJun, Jiang, Zhe, Shrestha, Mariusz

“…The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors…”
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Albumin-Binding Prodrugs of Camptothecin and Doxorubicin with an Ala-Leu-Ala-Leu-Linker That Are Cleaved by Cathepsin B:  Synthesis and Antitumor Efficacy by Schmid, Björn, Chung, Da-Eun, Warnecke, André, Fichtner, Iduna, Kratz, Felix

“…We have recently validated a macromolecular prodrug strategy for improved cancer chemotherapy based on two features:  (a) rapid and selective binding of…”
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RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation by Jones, Robert A, Robinson, Tyler J, Liu, Jeff C, Shrestha, Mariusz, Voisin, Veronique, Ju, YoungJun, Chung, Philip E D, Pellecchia, Giovanna, Fell, Victoria L, Bae, SooIn, Muthuswamy, Lakshmi, Datti, Alessandro, Egan, Sean E, Jiang, Zhe, Leone, Gustavo, Bader, Gary D, Schimmer, Aaron, Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the…”
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Thinking Box by Jiang, Zhe, Ju, Young-Jun, Ali, Amjad, Chung, Philip E. D, Wang, Dong-Yu, Liu, Jeff C, Li, Huiqin, Vorobieva, Ioulia, Mwewa, Ethel, Ghanbari-Azarnier, Ronak, Shrestha, Mariusz, Ben-David, Yaacov, Zacksenhaus, Eldad

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Early‐ and Late‐onset Complications of the Ketogenic Diet for Intractable Epilepsy by Kang, Hoon Chul, Chung, Da Eun, Kim, Dong Wook, Kim, Heung Dong

“…Purpose: This study was undertaken to evaluate the exact limitations of the ketogenic diet (KD) and to collect data on the prevention and management of its…”
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