Search Results - "Chung, Brian Y."

Circadian organization of behavior and physiology in Drosophila by Allada, Ravi, Chung, Brian Y

“…Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have…”
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Measurement of solid food intake in Drosophila via consumption-excretion of a dye tracer by Shell, Brandon C., Schmitt, Rebecca E., Lee, Kristen M., Johnson, Jacob C., Chung, Brian Y., Pletcher, Scott D., Grotewiel, Mike

“…Although the Drosophila melanogaster (fly) model is a popular platform for investigating diet-related phenomena, it can be challenging to measure the volume of…”
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Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior by Chung, Brian Y., Ro, Jennifer, Hutter, Sabine A., Miller, Kylie M., Guduguntla, Lakshmi S., Kondo, Shu, Pletcher, Scott D.

“…Proper regulation of sleep-wake behavior and feeding is essential for organismal health and survival. While previous studies have isolated discrete neural loci…”
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Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation by Tian, Linlu, Ogretmen, Besim, Chung, Brian Y., Yu, Xue-Zhong

“…Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapy against hematopoietic malignancies. The infused donor lymphocytes attack…”
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Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling by Waterson, Michael J., Chung, Brian Y., Harvanek, Zachary M., Ostojic, Ivan, Alcedo, Joy, Pletcher, Scott D.

“…Sensory perception modulates lifespan across taxa, presumably due to alterations in physiological homeostasis after central nervous system integration. The…”
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Gustatory and metabolic perception of nutrient stress in Drosophila by Linford, Nancy J, Ro, Jennifer, Chung, Brian Y, Pletcher, Scott D

“…Sleep loss is an adaptive response to nutrient deprivation that alters behavior to maximize the chances of feeding before imminent death. Organisms must…”
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The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster by Harrison, Benjamin R, Wang, Lu, Gajda, Erika, Hoffman, Elise V, Chung, Brian Y, Pletcher, Scott D, Raftery, Daniel, Promislow, Daniel E L

“…Genetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under…”
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Client Service Receipt Inventory as a standardised tool for measurement of socio-economic costs in the rare genetic disease population (CSRI-Ra) by Chung, Claudia C. Y., Fung, Jasmine L. F., Lui, Adrian C. Y., Chan, Marcus C. Y., Ng, Yvette N. C., Wong, Wilfred H. S., Lee, So Lun, Knapp, Martin, Chung, Brian H. Y.

“…The measurement of costs is fundamental in healthcare decision-making, but it is often challenging. In particular, standardised methods have not been developed…”
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Revealing the role of SPP1 + macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas by Tang, Wenshu, Lo, Cario W S, Ma, Wei, Chu, Annie T W, Tong, Amy H Y, Chung, Brian H Y

“…Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1-4 based on its malignancy. The suppressive immune…”
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Revealing parental mosaicism: the hidden answer to the recurrence of apparent de novo variants by Lee, Mianne, Lui, Adrian C. Y., Chan, Joshua C. K., Doong, Phoenix H. L., Kwong, Anna K. Y., Mak, Christopher C. Y., Li, Raymond H. W., Kan, Anita S. Y., Chung, Brian H. Y.

“…Abstract Mosaicism refers to the presence of two or more populations of genetically distinct cells within an individual, all of which originate from a single…”
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clockwork orange Encodes a Transcriptional Repressor Important for Circadian-Clock Amplitude in Drosophila by Lim, Chunghun, Chung, Brian Y., Pitman, Jena L., McGill, Jermaine J., Pradhan, Suraj, Lee, Jongbin, Keegan, Kevin P., Choe, Joonho, Allada, Ravi

“…Gene transcription is a central timekeeping process in animal clocks. In Drosophila, the basic helix-loop helix (bHLH)-PAS transcription-factor heterodimer,…”
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The different facets of “culture” in genetic counseling: A situated analysis of genetic counseling in Hong Kong by Zayts, Olga, Shipman, Hannah, Fung, Jasmine L.‐F., Liu, Anthony P.‐Y., Kwok, Sit‐Yee, Tsai, Anne C.‐H., Yung, Tak‐Cheung, Chung, Brian H.‐Y.

“…In this article, we problematize the concept of “culture” in genetic counseling. With globalization and increased mobility of both genetic professionals and…”
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Whole-genome array CGH evaluation for replacing prenatal karyotyping in Hong Kong by Kan, Anita S Y, Lau, Elizabeth T, Tang, W F, Chan, Sario S Y, Ding, Simon C K, Chan, Kelvin Y K, Lee, C P, Hui, Pui Wah, Chung, Brian H Y, Leung, K Y, Ma, Teresa, Leung, Wing C, Tang, Mary H Y

“…To evaluate the effectiveness of whole-genome array comparative genomic hybridization (aCGH) in prenatal diagnosis in Hong Kong. Array CGH was performed on 220…”
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Patient similarity and other artificial intelligence machine learning algorithms in clinical decision aid for shared decision-making in the Prevention of Cardiovascular Toxicity (PACT): a feasibility trial design by Brown, Sherry-Ann, Chung, Brian Y, Doshi, Krishna, Hamid, Abdulaziz, Pederson, Erin, Maddula, Ragasnehith, Hanna, Allen, Choudhuri, Indrajit, Sparapani, Rodney, Bagheri Mohamadi Pour, Mehri, Zhang, Jun, Kothari, Anai N, Collier, Patrick, Caraballo, Pedro, Noseworthy, Peter, Arruda-Olson, Adelaide

“…The many improvements in cancer therapies have led to an increased number of survivors, which comes with a greater risk of consequent/subsequent cardiovascular…”
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Diagnostic potential of the amniotic fluid cells transcriptome in deciphering mendelian disease: a proof-of-concept by Lee, Mianne, Kwong, Anna K. Y., Chui, Martin M. C., Chau, Jeffrey F. T., Mak, Christopher C. Y., Au, Sandy L. K., Lo, Hei Man, Chan, Kelvin Y. K., Yépez, Vicente A., Gagneur, Julien, Kan, Anita S. Y., Chung, Brian H. Y.

“…RNA sequencing (RNA-seq) is emerging in genetic diagnoses as it provides functional support for the interpretation of variants of uncertain significance…”
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Targeting Cellular Metabolism With CPI-613 Sensitizes Pancreatic Cancer Cells to Radiation Therapy by Khan, Husain Yar, Kamgar, Mandana, Aboukameel, Amro, Bannoura, Sahar, Chung, Brian Y., Li, Yiwei, Hallak, Mohammed Najeeb Al, Philip, Philip A., Tsai, Susan, Luther, Sanjeev, Hall, William A., Azmi, Asfar S.

“…Local tumor progression is a cause of significant morbidity and mortality in patients with pancreatic ductal adenocarcinoma (PDAC) with surgically unresectable…”
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The clinical impact of chromosomal microarray on paediatric care in Hong Kong by Tao, Victoria Q, Chan, Kelvin Y K, Chu, Yoyo W Y, Mok, Gary T K, Tan, Tiong Y, Yang, Wanling, Lee, So Lun, Tang, Wing Fai, Tso, Winnie W Y, Lau, Elizabeth T, Kan, Anita S Y, Tang, Mary H, Lau, Yu-Lung, Chung, Brian H Y

“…To evaluate the clinical impact of chromosomal microarray (CMA) on the management of paediatric patients in Hong Kong. We performed NimbleGen 135k…”
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A fatal case of COQ7‐associated primary coenzyme Q10 deficiency by Kwong, Anna K.‐Y., Chiu, Annie T.‐G., Tsang, Mandy H.‐Y., Lun, Kin‐Shing, Rodenburg, Richard J. T., Smeitink, Jan, Chung, Brian H.‐Y., Fung, Cheuk‐Wing

“…Background Primary coenzyme Q10 (CoQ10) deficiencies are clinically and genetically heterogeneous group of disorders associated with defects of genes involved…”
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22q11.2 deletion syndrome in diverse populations by Kruszka, Paul, Addissie, Yonit A., McGinn, Daniel E., Porras, Antonio R., Biggs, Elijah, Share, Matthew, Crowley, T. Blaine, Chung, Brian H. Y., Mok, Gary T. K., Mak, Christopher C. Y., Muthukumarasamy, Premala, Thong, Meow‐Keong, Sirisena, Nirmala D., Dissanayake, Vajira H. W., Paththinige, C. Sampath, Prabodha, L. B. Lahiru, Mishra, Rupesh, Shotelersuk, Vorasuk, Ekure, Ekanem Nsikak, Sokunbi, Ogochukwu Jidechukwu, Kalu, Nnenna, Ferreira, Carlos R., Duncan, Jordann‐Mishael, Patil, Siddaramappa Jagdish, Jones, Kelly L., Kaplan, Julie D., Abdul‐Rahman, Omar A., Uwineza, Annette, Mutesa, Leon, Moresco, Angélica, Obregon, María Gabriela, Richieri‐Costa, Antonio, Gil‐da‐Silva‐Lopes, Vera L., Adeyemo, Adebowale A., Summar, Marshall, Zackai, Elaine H., McDonald‐McGinn, Donna M., Linguraru, Marius George, Muenke, Maximilian

“…22q11.2 deletion syndrome (22q11.2 DS) is the most common microdeletion syndrome and is underdiagnosed in diverse populations. This syndrome has a variable…”
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The GABAA Receptor RDL Acts in Peptidergic PDF Neurons to Promote Sleep in Drosophila by Chung, Brian Y., Kilman, Valerie L., Keath, J. Russel, Pitman, Jena L., Allada, Ravi

“…Sleep is regulated by a circadian clock that times sleep and wake to specific times of day and a homeostat that drives sleep as a function of prior wakefulness…”
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