Search Results - "Chung, Brian K."

Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma by Chung, Brian K., Karlsen, Tom Hemming, Folseraas, Trine

“…Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated with inflammatory bowel disease (IBD) and characterized by…”
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Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis by Chung, Brian K., Øgaard, Jonas, Reims, Henrik Mikael, Karlsen, Tom H., Melum, Espen

“…Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet patient need. Recent use of single‐cell RNA sequencing (scRNAseq)…”
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Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis by Chung, Brian K, Guevel, Bardia T, Reynolds, Gary M, Gupta Udatha, D.B.R.K, Henriksen, Eva Kristine Klemsdal, Stamataki, Zania, Hirschfield, Gideon M, Karlsen, Tom Hemming, Liaskou, Evaggelia

“…Abstract Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated biliary diseases that demonstrate prominent and…”
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Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells by Allan, Lenka L., Hoefl, Katrin, Zheng, Dong-Jun, Chung, Brian K., Kozak, Frederick K., Tan, Rusung, van den Elzen, Peter

“…Natural killer T (NKT) cells are innate-like lymphocytes that recognize lipid antigens and have been shown to enhance B-cell activation and antibody…”
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Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants by Tucker, Lori B, Lamot, Lovro, Niemietz, Iwona, Chung, Brian K, Cabral, David A, Houghton, Kristin, Petty, Ross E, Morishita, Kimberly A, Rice, Gillian I, Turvey, Stuart E, Gibson, William T, Brown, Kelly L

“…Despite recent advances in the diagnosis and understanding of many autoinflammatory diseases, there are still a great number of patients with phenotypes that…”
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Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease by Chung, Brian K., Henriksen, Eva Kristine Klemsdal, Jørgensen, Kristin Kaasen, Karlsen, Tom H., Hirschfield, Gideon M., Liaskou, Evaggelia

“…B cells express an antigen‐specific B‐cell receptor (BCR) and may contribute to liver inflammation by recognizing shared antigens in the gut and liver. Herein,…”
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Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT by Al Khatib, Iman, Deng, Jingti, Lei, Yuanjiu, Torres-Odio, Sylvia, Rojas, Gladys R, Newman, Laura E, Chung, Brian K, Symes, Andrew, Zhang, Hongliang, Huang, Shar-yin N, Pommier, Yves, Khan, Aneal, Shadel, Gerald S, West, Andrew Phillip, Gibson, William T, Shutt, Timothy E

“…Abstract The recognition that cytosolic mitochondrial DNA (mtDNA) activates cyclic GMP–AMP synthase-stimulator of interferon genes (cGAS-STING) innate immune…”
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Single-Cell Transcriptomic Profiling of Cholangiocyte Organoids Derived from Bile Ducts of Primary Sclerosing Cholangitis Patients by Frank, Anna Katharina, Chung, Brian K., De Novales, Miguel Larraz Lopez, Engesæter, Lise Katrine, Hoyle, Henry William, Øgaard, Jonas, Heslop, James, Karlsen, Tom H., Tysoe, Olivia, Brevini, Teresa, Tchorz, Jan S., Vallier, Ludovic, Mohorianu, Irina, Sampaziotis, Fotios, Melum, Espen

“…Background and Aims Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disorder without effective medical treatment which is characterized by…”
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Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation by Jiang, Xiaojun, Otterdal, Kari, Chung, Brian K., Maucourant, Christopher, Rønneberg, Jørgen D., Zimmer, Christine L., Øgaard, Jonas, Boichuk, Yuliia, Holm, Sverre, Geanon, Daniel, Schneditz, Georg, Bergquist, Annika, Björkström, Niklas K., Melum, Espen

“…Chronic inflammation surrounding bile ducts contributes to the disease pathogenesis of most cholangiopathies. Poor efficacy of immunosuppression in these…”
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Innate immune control of EBV-infected B cells by invariant natural killer T cells by Chung, Brian K., Tsai, Kevin, Allan, Lenka L., Zheng, Dong Jun, Nie, Johnny C., Biggs, Catherine M., Hasan, Mohammad R., Kozak, Frederick K., van den Elzen, Peter, Priatel, John J., Tan, Rusung

“…Individuals with X-linked lymphoproliferative disease lack invariant natural killer T (iNKT) cells and are exquisitely susceptible to Epstein-Barr virus (EBV)…”
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Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease by Henriksen, Eva Kristine Klemsdal, Jørgensen, Kristin Kaasen, Kaveh, Fatemeh, Holm, Kristian, Hamm, David, Olweus, Johanna, Melum, Espen, Chung, Brian K, Eide, Tor J, Lundin, Knut E.A, Boberg, Kirsten Muri, Karlsen, Tom H, Hirschfield, Gideon M, Liaskou, Evaggelia

“…Graphical abstract…”
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Immunogenetics in primary sclerosing cholangitis by Chung, Brian K, Hirschfield, Gideon M

“…PURPOSE OF REVIEWPrimary sclerosing cholangitis (PSC) is a progressive biliary liver disorder strongly associated with inflammatory bowel disease (PSC-IBD). We…”
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Genetic Risk and the Development of Autoimmune Liver Disease by Karlsen, Tom H, Chung, Brian K

“…Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) have collectively been recognized as autoimmune liver…”
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Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease by Chung, Brian K, Karlsen, Tom H

“…Over the last 50 years, genetic studies have uncovered a spectrum of rare and common alleles that confer susceptibility to both Mendelian and complex forms of…”
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CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling by Allan, Lenka L, Stax, Annelein M, Zheng, Dong-Jun, Chung, Brian K, Kozak, Fred K, Tan, Rusung, van den Elzen, Peter

“…B cell activation and Ab production in response to protein Ags requires presentation of peptides for recruitment of T cell help. We and others have recently…”
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CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections by Chung, Brian K, Priatel, John J, Tan, Rusung

“…Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor…”
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Natural killer T cell strategies to combat Epstein-Barr virus infection by Priatel, John J, Chung, Brian K, Tsai, Kevin, Tan, Rusung

“…Epstein-Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune…”
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Duplication of AKT3 is associated with macrocephaly and speech delay by Chung, Brian K., Eydoux, Patrice, ∨an Karnebeek, Clara D., Gibson, William T.

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SAT-163-YI Spatial characteristics of cell compartments in primary sclerosing cholangitis by Jördens, Markus S., Øgaard, Jonas, Luedde, Tom, Karlsen, Tom Hemming, Chung, Brian K., Melum, Espen

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THU-525-YI Temporal and spatial development of cholestasis induced liver injury by Øgaard, Jonas, Sivertsen Nordhus, Kathrine, Jördens, Markus S., Chung, Brian K., Melum, Espen

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