Search Results - "Chunduru, SK"

Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-[kappa]B signaling by degrading TRAF2-associated cIAP1 in cancer cells by Mitsuuchi, Y, Benetatos, Ca, Deng, Y, Haimowitz, T, Beck, Sc, Arnone, Mr, Kapoor, Gs, Seipel, Me, Chunduru, Sk, Mckinlay, Ma, Begley, Cg, Condon, Sm

“…The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines…”
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Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells by Mitsuuchi, Y, Benetatos, CA, Deng, Y, Haimowitz, T, Beck, SC, Arnone, MR, Kapoor, GS, Seipel, ME, Chunduru, SK, McKinlay, MA, Begley, CG, Condon, SM

“…The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines…”
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Mechanism of Action of a Pestivirus Antiviral Compound by Baginski, Scott G., Pevear, Daniel C., Seipel, Marty, Siu Chi Chang Sun, Benetatos, Christopher A., Chunduru, Srinivas K., Rice, Charles M., Collett, Marc S.

“…We report here the discovery of a small molecule inhibitor of pestivirus replication. The compound, designated VP32947, inhibits the replication of bovine…”
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Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase by LaPorte, M.G., Lessen, T.A., Leister, L., Cebzanov, D., Amparo, E., Faust, C., Ortlip, D., Bailey, T.R., Nitz, T.J., Chunduru, S.K., Young, D.C., Burns, C.J.

“…A series of tetrahydrobenzothiophenes have been prepared and identified as potent inhibitors of HCV NS5B polymerase. R = 6,6-Dimethyl, R′ = CONHSO 2Ar. A novel…”
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Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers by Lewis, W S, Cody, V, Galitsky, N, Luft, J R, Pangborn, W, Chunduru, S K, Spencer, H T, Appleman, J R, Blakley, R L

“…Although substitution of tyrosine, phenylalanine, tryptophan, or arginine for leucine 22 in human dihydrofolate reductase greatly slows hydride transfer, there…”
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Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions by CHUNDURU, S. K, CODY, V, LUFT, J. R, PANGBORN, W, APPLEMAN, J. R, BLAKLEY, R. L

“…Substitution of glycine or alanine for phenylalanine 31 in human dihydrofolate reductase produces variants that are inhibited less by methotrexate (MTX) than…”
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Exploitation of the V beta 8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector by Chunduru, S K, Sutherland, R M, Stewart, G A, Doms, R W, Paterson, Y

“…This study takes advantage of the predominant usage of V beta 8.2 by the TCRs of encephalitogenic T cells specific for myelin basic protein. Vaccinia virus…”
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Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate by Spencer, H T, Sorrentino, B P, Pui, C H, Chunduru, S K, Sleep, S E, Blakley, R L

“…Resistance to methotrexate (MTX) in some sublines of mammalian cells is reported to be due to one of the following amino acid substitutions in dihydrofolate…”
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Mechanism of ketol acid reductoisomerase. Steady-state analysis and metal ion requirement by Chunduru, Srinivas K, Mrachko, Gregory T, Calvo, K. C

“…Ketol acid reductoisomerase is an enzyme of the branched-chain amino acid biosynthetic pathway. It catalyzes two separate reactions: an acetoin rearrangement…”
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Exploitation of the Vbeta8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector by Chunduru, SK, Sutherland, RM, Stewart, GA, Doms, RW, Paterson, Y

“…This study takes advantage of the predominant usage of Vbeta8.2 by the TCRs of encephalitogenic T cells specific for myelin basic protein. Vaccinia virus…”
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The pH dependence of the kinetic parameters of ketol acid reductoisomerase indicates a proton shuttle mechanism for alkyl migration by Mrachko, G T, Chunduru, S K, Calvo, K C

“…The enzyme ketol acid reductoisomerase catalyzes the second common reaction in the biosynthesis of the branched chain amino acids. The reaction is complex as…”
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Mutations of human dihydrofolate reductase causing decreased inhibition by methotrexate by Blakley, R L, Appleman, J R, Chunduru, S K, Nakano, T, Lewis, W S, Harris, S E

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