Search Results - "Chun, Nicolette"

Racial/ethnic differences in multiple-gene sequencing results for hereditary cancer risk by Caswell-Jin, Jennifer L, Gupta, Tanya, Hall, Evan, Petrovchich, Iva M, Mills, Meredith A, Kingham, Kerry E, Koff, Rachel, Chun, Nicolette M, Levonian, Peter, Lebensohn, Alexandra P, Ford, James M, Kurian, Allison W

“…Purpose We examined racial/ethnic differences in the usage and results of germ-line multiple-gene sequencing (MGS) panels to evaluate hereditary cancer risk…”
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Psychosocial outcomes following germline multigene panel testing in an ethnically and economically diverse cohort of patients by Culver, Julie O., Ricker, Charité N., Bonner, Joseph, Kidd, John, Sturgeon, Duveen, Hodan, Rachel, Kingham, Kerry, Lowstuter, Katrina, Chun, Nicolette M., Lebensohn, Alexandra P., Rowe‐Teeter, Courtney, Levonian, Peter, Partynski, Katlyn, Lara‐Otero, Karlena, Hong, Christine, Morales Pichardo, Jennifer, Mills, Meredith A., Brown, Krystal, Lerman, Caryn, Ladabaum, Uri, McDonnell, Kevin J., Ford, James M., Gruber, Stephen B., Kurian, Allison W., Idos, Gregory E.

“…Background Little is known about the psychological outcomes of germline multigene panel testing, particularly among diverse patients and those with…”
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Clinical implications of conflicting variant interpretations in the cancer genetics clinic by Zukin, Elyssa, Culver, Julie O., Liu, Yuxi, Yang, Yunqi, Ricker, Charité N., Hodan, Rachel, Sturgeon, Duveen, Kingham, Kerry, Chun, Nicolette M., Rowe-Teeter, Courtney, Singh, Kathryn, Zell, Jason A., Ladabaum, Uri, McDonnell, Kevin J., Ford, James M., Parmigiani, Giovanni, Braun, Danielle, Kurian, Allison W., Gruber, Stephen B., Idos, Gregory E.

“…The aim of this study was to describe the clinical impact of commercial laboratories issuing conflicting classifications of genetic variants. Results from 2000…”
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Parent decision‐making around the genetic testing of children for germline TP53 mutations by Alderfer, Melissa A, Zelley, Kristin, Lindell, Robert B, Novokmet, Ana, Mai, Phuong L, Garber, Judy E, Nathan, Deepika, Scollon, Sarah, Chun, Nicolette M, Patenaude, Andrea F, Ford, James M, Plon, Sharon E, Schiffman, Joshua D, Diller, Lisa R, Savage, Sharon A, Malkin, David, Ford, Carol A, Nichols, Kim E

“…BACKGROUND Li‐Fraumeni syndrome is a rare genetic cancer predisposition syndrome caused by germline TP53 mutations. Up to 20% of mutation carriers develop…”
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Patient communication of cancer genetic test results in a diverse population by Ricker, Charité N, Koff, Rachel B, Qu, Chenxu, Culver, Julie, Sturgeon, Duveen, Kingham, Kerry E, Lowstuter, Katrina, Chun, Nicolette M, Rowe-Teeter, Courtney, Lebensohn, Alexandra, Levonian, Peter, Partynski, Katlyn, Lara-Otero, Karlena, Hong, Christine, Petrovchich, Iva M, Mills, Meredith A, Hartman, Anne-Renee, Allen, Brian, Ladabaum, Uri, McDonnell, Kevin, Ford, James M, Gruber, Stephen B, Kurian, Allison W, Idos, Gregory E

“…Patients with mutations in cancer risk genes from diverse ethnic and social backgrounds mostly all shared their genetic test results with family members…”
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Performance of BRCA1/2 Mutation Prediction Models in Asian Americans by Kurian, Allison W, Gong, Gail D, Chun, Nicolette M, Mills, Meredith A, Staton, Ashley D, Kingham, Kerry E, Crawford, Beth B, Lee, Robin, Chan, Salina, Donlon, Susan S, Ridge, Yolanda, Panabaker, Karen, West, Dee W, Whittemore, Alice S, Ford, James M

“…There are established differences in breast cancer epidemiology between Asian and white individuals, but little is known about hereditary breast cancer in…”
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Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation by Matsukuma, Karen E., MD, PhD, Mullins, Franklin M., MD, PhD, Dietz, Lisa, BS, Zehnder, James L., MD, Ford, James M., MD, Chun, Nicolette M., MS, Schrijver, Iris, MD

“…Summary Our patient was a 52-year-old man who was diagnosed with signet ring cell gastric adenocarcinoma. An extensive family history of gastric cancer raised…”
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Ductal Lavage of Fluid-Yielding and Non–Fluid-Yielding Ducts in BRCA1 and BRCA2 Mutation Carriers and Other Women at High Inherited Breast Cancer Risk by KURIAN, Allison W, MILLS, Meredith A, FORD, James M, HARTMAN, Anne-Renee, JAFFEE, Margo, SIGAL, Bronislava M, CHUN, Nicolette M, KINGHAM, Kerry E, COLLINS, Laura C, NOWELS, Kent W, PLEVRITIS, Sylvia K, GARBER, Judy E

“…Objective: Nipple fluid production and atypical breast duct cells in women at high risk of breast cancer have been associated with further increased risk. Most…”
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Somatic tumor mutations in moderate risk cancer genes: Targets for germline confirmatory testing by Llorin, Hannah, Graf, Madeline, Chun, Nicolette, Ford, James

“…•Recent guideline changes dramatically increase eligibility for germline testing among patients with somatic mutations in moderate risk breast and ovarian…”
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Understanding variants of uncertain significance in the era of multigene panels: Through the eyes of the patient by Reuter, Chloe, Chun, Nicolette, Pariani, Mitchel, Hanson‐Kahn, Andrea

“…Variants of uncertain significance (VUSs) are often disclosed to patients despite ambiguous association with disease risk and lack of clinical actionability…”
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CDC73 c.1155-3A > G is a pathogenic variant that causes aberrant splicing, disrupted parafibromin expression and hyperparathyroidism-jaw tumor syndrome by Needleman, Leor, Chun, Nicolette, Sitaraman, Sathvika, Tan, Marilyn, Sellmeyer, Deborah E, Kebebew, Electron, Annes, Justin P

“…Abstract Germline and somatic pathogenic variants in the CDC73 gene, encoding the nuclear protein parafibromin, increase the risk for parathyroid carcinoma and…”
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Family health beliefs and cascade genetic testing in Asian families with hereditary cancer risk: "Okay, now what?" by Tran, Leena, Young, Jennifer L, Barton, Claire M, Hodan, Rachel, Hanson-Kahn, Andrea, Chun, Nicolette

“…The limited literature on Asian family communication of hereditary cancer risk and cascade genetic testing for pathogenic variants (PVs) in BRCA1 and BRCA2 has…”
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Somatic tumor testing implications for Lynch syndrome germline genetic testing by Barrus, Kathleen, Purington, Natasha, Chun, Nicolette, Ladabaum, Uri, Ford, James M.

“…Clinicians involved in cancer treatment often utilize somatic tumor sequencing to help tailor chemotherapy and immunotherapy. However, somatic tumor sequencing…”
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Germline Testing for Patients With BRCA1/2 Mutations on Somatic Tumor Testing by Vlessis, Katherine, Purington, Natasha, Chun, Nicolette, Haraldsdottir, Sigurdis, Ford, James M

“…The National Comprehensive Cancer Network (NCCN) recommends germline testing for pathogenic mutations identified by somatic tumor sequencing. The aim of this…”
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Preventive surgery after multiplex genetic panel testing (MGPT) by Idos, Gregory, Kurian, Allison W., Ricker, Charité, Sturgeon, Duveen, Culver, Julie, Kingham, Kerry, Koff, Rachel, Chun, Nicolette M., Rowe-Teeter, Courtney, Levonian, Peter, Hong, Christine, Mills, Meredith, Ma, Cindy, Lancaster, Johnathan M., Brown, Krystal, Kidd, John, McDonnell, Kevin, Ladabaum, Uri, Ford, James M., Gruber, Stephen B.

“…Abstract only 1525 Background: Guidelines recommend consideration of prophylactic surgery for patients with a germline pathogenic variant in some cancer…”
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Promoting colorectal cancer (CRC) screening after multiplex genetic testing and genetic counseling by Idos, Gregory, Kurian, Allison W., Ricker, Charite, Sturgeon, Duveen, Culver, Julie, Kingham, Kerry, Koff, Rachel, Chun, Nicolette M., Rowe-Teeter, Courtney, Kidd, John, Evans, Brent, Brown, Krystal, Mills, Meredith, Ma, Cindy, Hong, Christine, McDonnell, Kevin, Ladabaum, Uri, Ford, James M., Gruber, Stephen B.

“…Abstract only…”
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Promoting breast cancer screening after multiplex genetic panel testing (MGPT) and genetic counseling by Idos, Gregory, Kurian, Allison W., Ricker, Charite, Sturgeon, Duveen, Culver, Julie, Kingham, Kerry, Koff, Rachel, Chun, Nicolette M., Rowe-Teeter, Courtney, Kidd, John, Evans, Brent, Brown, Krystal, Mills, Meredith, Ma, Cindy, Hong, Christine, McDonnell, Kevin J, Ladabaum, Uri, Ford, James M., Gruber, Stephen B.

“…Abstract only…”
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The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype by Kwok, Chau-To, Vogelaar, Ingrid P, van Zelst-Stams, Wendy A, Mensenkamp, Arjen R, Ligtenberg, Marjolijn J, Rapkins, Robert W, Ward, Robyn L, Chun, Nicolette, Ford, James M, Ladabaum, Uri, McKinnon, Wendy C, Greenblatt, Marc S, Hitchins, Megan P

“…Germline mutations of the DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2, and deletions affecting the EPCAM gene adjacent to MSH2, underlie Lynch syndrome…”
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Safety of multiplex gene testing for inherited cancer risk in a fully accrued prospective trial by Kurian, Allison W., Idos, Gregory, Ricker, Charite Nicolette, Culver, Julie, Sturgeon, Duveen, Kingham, Kerry, Koff, Rachel, Lowstuter, Katrina, Chun, Nicolette M., Rowe-Teeter, Courtney, Partynski, Katlyn, Hartman, Anne-Renee, Allen, Brian, Kidd, John, Mills, Meredith, Hong, Christine, McDonnell, Kevin, Ladabaum, Uri, Ford, James M., Gruber, Stephen B.

“…Abstract only 1576 Background: Sequencing more genes increases the chance of finding a pathogenic mutation and/or a variant of uncertain significance (VUS)…”
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Expanded yield of multiplex panel testing in fully accrued prospective trial by Idos, Gregory, Kurian, Allison W., Ricker, Charite Nicolette, Sturgeon, Duveen, Culver, Julie, Kingham, Kerry, Koff, Rachel, Chun, Nicolette M., Rowe-Teeter, Courtney, Lowstuter, Katrina, Hartman, Anne-Renee, Allen, Brian, Kidd, John, Mills, Meredith, Ma, Cindy, Hong, Christine, McDonnell, Kevin, Ladabaum, Uri, Ford, James M., Gruber, Stephen B.

“…Abstract only 1525 Background: Genetic testing is a powerful tool for stratifying cancer risk. Multiplex gene panel (MGP) testing allows simultaneous analysis…”
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