Search Results - "Chun, J"

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins by Schumann, Kathrin, Lin, Steven, Boyer, Eric, Simeonov, Dimitre R., Subramaniam, Meena, Gate, Rachel E., Haliburton, Genevieve E., Ye, Chun J., Bluestone, Jeffrey A., Doudna, Jennifer A., Marson, Alexander

“…T-cell genome engineering holds great promise for cell-based therapies for cancer, HIV, primary immune deficiencies, and autoimmune diseases, but genetic…”
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Functional interpretation of single cell similarity maps by DeTomaso, David, Jones, Matthew G., Subramaniam, Meena, Ashuach, Tal, Ye, Chun J., Yosef, Nir

“…We present Vision , a tool for annotating the sources of variation in single cell RNA-seq data in an automated and scalable manner. Vision operates directly on…”
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Microbial Genetic Composition Tunes Host Longevity by Han, Bing, Sivaramakrishnan, Priya, Lin, Chih-Chun J., Neve, Isaiah A.A., He, Jingquan, Tay, Li Wei Rachel, Sowa, Jessica N., Sizovs, Antons, Du, Guangwei, Wang, Jin, Herman, Christophe, Wang, Meng C.

“…Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new…”
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CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells by Rupp, Levi J., Schumann, Kathrin, Roybal, Kole T., Gate, Rachel E., Ye, Chun J., Lim, Wendell A., Marson, Alexander

“…Immunotherapies with chimeric antigen receptor (CAR) T cells and checkpoint inhibitors (including antibodies that antagonize programmed cell death protein 1…”
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Lineage dynamics of murine pancreatic development at single-cell resolution by Byrnes, Lauren E., Wong, Daniel M., Subramaniam, Meena, Meyer, Nathaniel P., Gilchrist, Caroline L., Knox, Sarah M., Tward, Aaron D., Ye, Chun J., Sneddon, Julie B.

“…Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time. Here, we…”
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Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla by Bautista, Jhoanne L., Cramer, Nathan T., Miller, Corey N., Chavez, Jessica, Berrios, David I., Byrnes, Lauren E., Germino, Joe, Ntranos, Vasilis, Sneddon, Julie B., Burt, Trevor D., Gardner, James M., Ye, Chun J., Anderson, Mark S., Parent, Audrey V.

“…The thymus’ key function in the immune system is to provide the necessary environment for the development of diverse and self-tolerant T lymphocytes. While…”
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Transcatheter Embolisation of Type 1 Endoleaks after Endovascular Aortic Aneurysm Repair with Onyx: When No Other Treatment Option is Feasible by Chun, J.-Y, Morgan, R

“…Abstract Type 1 endoleaks following endovascular aortic aneurysm repair are associated with poor outcomes and re-intervention is recommended as soon as…”
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Optogenetic control of gut bacterial metabolism to promote longevity by Hartsough, Lucas A, Park, Mooncheol, Kotlajich, Matthew V, Lazar, John Tyler, Han, Bing, Lin, Chih-Chun J, Musteata, Elena, Gambill, Lauren, Wang, Meng C, Tabor, Jeffrey J

“…Gut microbial metabolism is associated with host longevity. However, because it requires direct manipulation of microbial metabolism in situ, establishing a…”
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Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation by Gu, Sean X., Tyagi, Tarun, Jain, Kanika, Gu, Vivian W., Lee, Seung Hee, Hwa, Jonathan M., Kwan, Jennifer M., Krause, Diane S., Lee, Alfred I., Halene, Stephanie, Martin, Kathleen A., Chun, Hyung J., Hwa, John

“…The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that…”
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Effects of Al Precursors on Deposition Selectivity of Atomic Layer Deposition of Al2O3 Using Ethanethiol Inhibitor by Kim, Hyun Gu, Kim, Miso, Gu, Bonwook, Khan, Mohammad Rizwan, Ko, Byeong Guk, Yasmeen, Sumaira, Kim, Chang Su, Kwon, Se-Hun, Kim, Jiyong, Kwon, Junhyuck, Jin, Kwangseon, Cho, Byungchul, Chun, J. -S, Shong, Bonggeun, Lee, Han-Bo-Ram

“…Area-selective atomic layer deposition (AS-ALD) is a promising bottom-up patterning approach for fabricating conformal thin films. One of the current…”
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The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration by Jafar-nejad, Paymaan, Powers, Berit, Soriano, Armand, Zhao, Hien, Norris, Daniel A, Matson, John, DeBrosse-Serra, Beatrice, Watson, Jamie, Narayanan, Padmakumar, Chun, Seung J, Mazur, Curt, Kordasiewicz, Holly, Swayze, Eric E, Rigo, Frank

“…Abstract Antisense oligonucleotides (ASOs) have emerged as a new class of drugs to treat a wide range of diseases, including neurological indications…”
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The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation by Lv, Lin L, Tang, Patrick Ming-Kuen, Li, Chun J, You, Yong K, Li, Jinhong, Huang, Xiao-Ru, Ni, Jun, Feng, Min, Liu, Bi C, Lan, Hui-Yao

“…Mincle (macrophage-inducible C-type lectin, Clec4e) is a transmembrane pattern recognition receptor involving the innate immunity, but its role in kidney…”
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Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity by Binnewies, Mikhail, Mujal, Adriana M., Pollack, Joshua L., Combes, Alexis J., Hardison, Emily A., Barry, Kevin C., Tsui, Jessica, Ruhland, Megan K., Kersten, Kelly, Abushawish, Marwan A., Spasic, Marko, Giurintano, Jonathan P., Chan, Vincent, Daud, Adil I., Ha, Patrick, Ye, Chun J., Roberts, Edward W., Krummel, Matthew F.

“…Differentiation of proinflammatory CD4+ conventional T cells (Tconv) is critical for productive antitumor responses yet their elicitation remains poorly…”
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Role of Alkali Cations in Stabilizing Mixed-Cation Perovskites to Thermal Stress and Moisture Conditions by Maniyarasu, Suresh, Ke, J. Chun-Ren, Spencer, Ben F, Walton, Alex S, Thomas, Andrew G, Flavell, Wendy R

“…Perovskite solar cells (PSCs) based on organic–inorganic hybrid perovskites containing a small fraction of substituted alkali-metal cations have shown…”
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Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis by Lee, M, Won, Y, Shin, Y, Kim, J.-H, Chun, J.-S

“…Summary Objective Hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis in chondrocytes serve as catabolic regulators of osteoarthritic cartilage…”
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Physician associates in interventional radiology: a new paradigm? by Lewis, L, Das, R, Ratnam, L, Chun, J-Y, Mailli, L, Ameli-Renani, S-M, Gonsalves, M, Morgan, R

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Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure by Oelen, Roy, de Vries, Dylan H., Brugge, Harm, Gordon, M. Grace, Vochteloo, Martijn, Ye, Chun J., Westra, Harm-Jan, Franke, Lude, van der Wijst, Monique G. P.

“…The host’s gene expression and gene regulatory response to pathogen exposure can be influenced by a combination of the host’s genetic background, the type of…”
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Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD+ -SIRT axis in articular chondrocytes is involved in osteoarthritis by Oh, H, Kwak, J.-S, Yang, S, Gong, M.-K, Kim, J.-H, Rhee, J, Kim, S.K, Kim, H.-E, Ryu, J.-H, Chun, J.-S

“…Summary Objective Hypoxia-inducible factor-2α (HIF-2α) transcriptionally upregulates Nampt in articular chondrocytes. NAMPT, which exhibits nicotinamide…”
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A tissue checkpoint regulates type 2 immunity by Van Dyken, Steven J, Nussbaum, Jesse C, Lee, Jinwoo, Molofsky, Ari B, Liang, Hong-Erh, Pollack, Joshua L, Gate, Rachel E, Haliburton, Genevieve E, Ye, Chun J, Marson, Alexander, Erle, David J, Locksley, Richard M

“…Type 2 responses can be elicited by ILC2s and T H 2 cells. Locksley and colleagues show that the epithelium-derived cytokines IL-25, IL-33 and TSLP are…”
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Dealing with complications in interventional radiology by Oseni, A. O., Chun, J.-Y., Morgan, R., Ratnam, L.

“…It is widely accepted that most misadventures, which lead to harm have not occurred because of a single individual but rather due to a failure of process that…”
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