Analysis of Acute Phase Response Using Acute Phase Proteins Following Simultaneous Vaccination of Lumpy Skin Disease and Foot-and-Mouth Disease

Since 2011, South Korea has implemented biannual vaccinations against foot-and-mouth disease (FMD) and recently, lumpy skin disease (LSD), to mitigate the spread of transboundary animal diseases. However, due to past adverse reactions, potentially linked to acute phase responses from FMD vaccination...

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Bibliographic Details
Published in:	Vaccines (Basel) Vol. 12; no. 5; p. 556
Main Authors:	Kim, Jiyeon, Kim, Danil, Noh, Hyoeun, Hong, Leegon, Chun, Eunwoo, Kim, Eunkyung, Ro, Younghye, Choi, Woojae
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-05-2024
Subjects:	acute phase protein Acute phase proteins Adjuvants adverse reactions Amyloid precursor protein Animal diseases Animal health Blood Cattle Cytokines Disease control Disease transmission Fever Foot & mouth disease foot-and-mouth disease Immune response Livestock Livestock farming Lumpy skin disease Milk Plasma Proteins Side effects Skin Skin diseases Vaccination Vaccines South Korea Turkey United States > US Africa lumpy skin disease foot-and-mouth disease adverse reactions acute phase protein vaccination
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Summary:	Since 2011, South Korea has implemented biannual vaccinations against foot-and-mouth disease (FMD) and recently, lumpy skin disease (LSD), to mitigate the spread of transboundary animal diseases. However, due to past adverse reactions, potentially linked to acute phase responses from FMD vaccinations, there is hesitancy among Korean livestock farmers regarding new strategies for simultaneous vaccinations against both FMD and LSD. This study was conducted to assess possible adverse reactions to the LSD vaccination by analyzing acute phase proteins (APPs) in three groups: cows vaccinated against FMD (G1-FMDV), LSD (G2-LSDV), and both (G3-FMDV/LSDV). In G1-FMDV, APP levels peaked on day 3 post-vaccination ( < 0.001) and returned to baseline. In G2-LSDV, APP levels increased gradually, peaking on day 10 post-vaccination. In G3-FMDV/LSDV, APP levels peaked on day 3 post-vaccination and remained high until day 10 ( < 0.001). These results indicate that LSD vaccines trigger a later immune response compared to FMD vaccines, possibly due to different adjuvants. Therefore, a longer follow-up period for monitoring adverse reactions to LSD vaccinations may be required to understand and mitigate potential risks.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2076-393X 2076-393X
DOI:	10.3390/vaccines12050556