Search Results - "Chulkina, Marina"

Role of PD-L1 in Gut Mucosa Tolerance and Chronic Inflammation by Chulkina, Marina, Beswick, Ellen J, Pinchuk, Irina V

“…The gastrointestinal (GI) mucosa is among the most complex systems in the body. It has a diverse commensal microbiome challenged continuously by food and…”
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Drug-Microbiota Interaction in Colon Cancer Therapy: Impact of Antibiotics by Mohamed, Ali, Menon, Harry, Chulkina, Marina, Yee, Nelson S, Pinchuk, Irina V

“…Colon adenocarcinoma is one of the most common malignancies, and it is highly lethal. Chemotherapy plays an important role in the treatment of colon cancer at…”
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The differences in immunoadjuvant mechanisms of TLR3 and TLR4 agonists on the level of antigen-presenting cells during immunization with recombinant adenovirus vector by Lebedeva, Ekaterina, Bagaev, Alexander, Pichugin, Alexey, Chulkina, Marina, Lysenko, Andrei, Tutykhina, Irina, Shmarov, Maxim, Logunov, Denis, Naroditsky, Boris, Ataullakhanov, Ravshan

“…Agonists of TLR3 and TLR4 are effective immunoadjuvants for different types of vaccines. The mechanisms of their immunostimulatory action differ significantly;…”
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Su1735 HYPERACTIVATION OF TGF-BETA SIGNALING IN INTESTINAL FIBROBLASTS AGGRAVATES INTESTINAL INFLAMMATION AND FIBROSIS IN MICE by Chulkina, Marina, McAninch, Steven B., McAninch, Christina, Pinchuk, Irina V.

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Tu1816 JAK2/STAT SIGNALING: ROLE IN GENERATION OF INFLAMMATORY MESENCHYMAL CELLS IN ULCERATIVE COLITIS by Rohmer, Christina, Chulkina, Marina, McAninch, Steven B., Koltun, Walter, Yochum, Gregory S., Powell, Don W., Pinchuk, Iryna V.

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1138 JAK2 OVEREXPRESSION IN MESENCHYMAL CELLS CONTRIBUTE TO THE IMMUNOPATHOGENESIS OF UC AND IS A POTENTIAL THERAPEUTIC TARGET by Panganiban, Ronaldo P., McAninch, Christina, Chulkina, Marina, McAninch, Steven B., Edwards, Rachael M., Seideneck, Ashley M., Koltun, Walter, Yochum, Gregory, Pinchuk, Irina V.

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INCREASE IN MK2 ACTIVITY IN CROHN’S DISEASE: ROLE IN THE INFLAMMATORY ACTIVATION OF FIBROBLASTS by Chulkina, Marina, McAninch, Steven, Ehudin, Melanie, Dovat, Sinisa, Koltun, Walter, Yochum, Gregory, Valentine, John, Beswick, Ellen, Pinchuk, Irina

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ACTIVATION OF MK2 IN CROHN’S DISEASE-ASSOCIATED FIBROSIS: NEW TARGET FOR ANTI-FIBROTIC THERAPY by Chulkina, Marina, McAninch, Steven, Ehudin, Melanie, Cohen, Claire, Dovat, Sinisa, Koltun, Walter, Yochum, Gregory, Pinchuk, Irina, Beswick, Ellen

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344 ACTIVATION OF MK2-TTP SIGNALING AS A DRIVER OF PATHOLOGICAL CHANGES IN INTESTINAL FIBROBLASTS IN CROHN'S DISEASE by Chulkina, Marina, McAninch, Steven B., Rohmer, Christina, Markov, Nikolay S., He, Bing, Koltun, Walter, Yochum, Gregory, Beswick, Ellen J., Pinchuk, Iryna V.

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174 BRD4 AS A POTENTIAL THERAPEUTIC TARGET FOR CROHN'S DISEASEASSOCIATED FIBROSIS by McAninch, Christina, Chulkina, Marina, Ma, Zonghui, McAninch, Steven B., Edwards, Rachael M., Seideneck, Ashley, Panganiban, Ronaldo P., Chen, Haiying, Koltun, Walter, Yochum, Gregory, Tian, Bing, Zhou, Jia, Pinchuk, Irina V.

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INCREASE IN MK2 ACTIVITY IN CROHN’S DISEASE: ROLE IN THE INFLAMMATORY ACTIVATION OF FIBROBLASTS by Chulkina, Marina, McAninch, Steven, Ehudin, Melanie, Dovat, Sinisa, Koltun, Walter, Yochum, Gregory, Valentine, John, Beswick, Ellen, Pinchuk, Irina

“…Abstract INTRODUCTION AND HYPOTHESIS Mesenchymal cells known as myo-/fibroblasts (MFs) are critical immunosuppressors under gut mucosal homeostasis. Expression…”
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ACTIVATION OF MK2 IN CROHN’S DISEASE-ASSOCIATED FIBROSIS: NEW TARGET FOR ANTI-FIBROTIC THERAPY by Chulkina, Marina, McAninch, Steven, Ehudin, Melanie, Cohen, Claire, Dovat, Sinisa, Koltun, Walter, Yochum, Gregory, Pinchuk, Irina, Beswick, Ellen

“…Abstract INTRODUCTION Fibrosis is the major aggressive complication of Crohn’s disease (CD), causing intestinal obstruction. No targeted therapies are…”
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457: INCREASE IN MK2 ACTIVITY IN CROHN'S DISEASE: ROLE IN THE INFLAMMATORY ACTIVATION OF FIBROBLASTS by Chulkina, Marina, McAninch, Steven B., Dovat, Sinisa, Koltun, Walter, Yochum, Gregory S., Valentine, John F., Beswick, Ellen J., Pinchuk, Iryna V.

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11: BRD4-MK2 SIGNALING: TARGET FOR CROHN'S DISEASE-ASSOCIATED FIBROSIS by Chulkina, Marina, McAninch, Steven B., Li, Yi, Koltun, Walter, Yochum, Gregory S., Tian, Bing, Zhou, Jia, Beswick, Ellen J., Brasier, Allan R., Pinchuk, Iryna V.

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MyD88-mediated signaling in myo-/fibroblasts is required for control of macrophage maturation under mucosal tolerance in the gut by Chulkina, Marina, Uribe, Gabriela, He, Bing, McAninch, Steven, Khanipov, Kamil, Golovko, George, Markov, Nikolay S., Powell, Don W, Beswick, Ellen, Pinchuk, Iryna V.

“…Abstract Introduction Colonic myo-/fibroblasts (MFs) are cells of mesenchymal origin in a healthy gut are among the key players in the mucosal tolerance that…”
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Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism by Villéger, Romain, Chulkina, Marina, Mifflin, Randy C, Powell, Don W, Pinchuk, Irina V

“…Stromal myo-/fibroblasts (MFs) account for up to 30% of lamina propria cells in the normal human colon and their number is dramatically increased in colon…”
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BRD4‐MK2 signaling: target for Crohn’s Disease‐associated fibrosis by Chulkina, Marina, McAninch, Steven, Li, Yi, Koltun, Walter, Yochum, Gregory, Tian, Bing, Zhou, Jia, Beswick, Ellen J., Brasier, Allan R., Pinchuk, Irina V.

“…Introduction Fibrosis is the major complication of Crohn’s disease (CD). No targeted therapies are currently available to revert CD‐associated fibrosis. While…”
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Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts by Chulkina, Marina, Negmadjanov, Ulugbek, Lebedeva, Ekaterina, Pichugin, Aleksey, Mazurov, Dmitriy, Ataullakhanov, Ravshan, Holmuhamedov, Ekhson

“…Synthetic 14 AA peptide (Gepon) derived from the hinge region of ezrin, a protein that links cell surface molecules to intracellular actin filaments,…”
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Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer by Villéger, Romain, Chulkina, Marina, Mifflin, Randy C., Markov, Nikolay S., Trieu, Judy, Sinha, Mala, Johnson, Paul, Saada, Jamal I., Adegboyega, Patrick A., Luxon, Bruce A., Beswick, Ellen J., Powell, Don W., Pinchuk, Irina V.

“…Background Increases in IL-6 by cancer-associated fibroblasts (CAFs) contribute to colon cancer progression, but the mechanisms involved in the increase of…”
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Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease by Chulkina, Marina, Rohmer, Christina, McAninch, Steven, Panganiban, Ronaldo P, Villéger, Romain, Portolese, Austin, Ciocirlan, Justin, Yang, Wenjing, Cohen, Claire, Koltun, Walter, Valentine, John F, Cong, Yingzi, Yochum, Gregory, Beswick, Ellen J, Pinchuk, Irina V

“…Mesenchymal stromal cells are suggested to play a critical role in Crohn's disease [CD]-associated fibrosis. MAPKAPK2 [MK2] has emerged as a potential…”
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