Search Results - "Chul Kang"
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Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Published in Nature communications (05-08-2021)“…Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological…”
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The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
Published in Nature communications (05-03-2019)“…Accurate genome-wide detection of somatic mutations with low variant allele frequency (VAF, <1%) has proven difficult, for which generalized, scalable methods…”
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Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
Published in Nature medicine (01-04-2015)“…Deep sequencing identifies somatic activating mutations of MTOR in affected brain regions of FCDII patients that are sufficient to cause neuronal migration…”
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Tumor Regression In Vivo by Photothermal Therapy Based on Gold-Nanorod-Loaded, Functional Nanocarriers
Published in ACS nano (22-03-2011)“…We developed a very effective hyperthermia system for successful photothermal cancer therapy. Instead of applying individual gold nanorods (GNRs) that can…”
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5
Common genes and recurrent causative variants in 957 Asian patients with pediatric epilepsy
Published in Epilepsia (Copenhagen) (01-03-2024)“…Objective We aimed to identify common genes and recurrent causative variants in a large group of Asian patients with different epilepsy syndromes and…”
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Estimating Cloth Simulation Parameters From Tag Information and Cusick Drape Test
Published in Computer graphics forum (01-05-2024)“…In recent years, the fashion apparel industry has been increasingly employing virtual simulations for the development of new products. The first step in…”
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Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy
Published in Epilepsia (Copenhagen) (01-01-2016)“…Summary Objective We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the…”
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Precise detection of low-level somatic mutation in resected epilepsy brain tissue
Published in Acta neuropathologica (01-12-2019)“…Low-level somatic mutations have been shown to be the major genetic etiology of intractable epilepsy. The extents thereof, however, have yet to be…”
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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination
Published in Neuron (Cambridge, Mass.) (11-07-2018)“…Focal malformations of cortical development (FMCDs), including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are major etiologies of pediatric…”
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10
BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors
Published in Nature medicine (01-11-2018)“…Pediatric brain tumors are highly associated with epileptic seizures 1 . However, their epileptogenic mechanisms remain unclear. Here, we show that the…”
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Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia
Published in American journal of human genetics (02-03-2017)“…Focal cortical dysplasia (FCD) is a major cause of the sporadic form of intractable focal epilepsies that require surgical treatment. It has recently been…”
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Characterization of Weissella confusa DD_A7 isolated from kimchi
Published in Food science & technology (01-08-2019)“…Foodborne pathogenic bacteria like, Escherichia coli 0157:H7, Bacillus cereus and Salmonella typhimurium are the biggest threat to food industries. Their…”
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Determination of Dy substitution site in Nd2−xDyxFe14B by HAADF-STEM and illustration of magnetic anisotropy of “g” and “f” sites, before and after substitution
Published in Scientific reports (18-03-2021)“…Nd 2 Fe 14 B and Nd 2−x Dy x Fe 14 B (x = 0.25, 0.50) particles were prepared by the modified co-precipitation followed by reduction–diffusion process. Bright…”
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Effect of Different Grain Boundary Diffusion Alloys on Magnetic Properties of Dy-Free Sintered NdFeB Magnet
Published in IEEE transactions on magnetics (01-09-2024)“…Dy-free sintered magnets were fabricated by blending Neo powder with different grain boundary diffusion (GBD) alloy powders. Cu, CeAl, and CeAlCu have a…”
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Mathematical Modeling and Analysis of a Piston Air Compressor of a Railway Vehicle for Abnormal Data Generation
Published in International journal of control, automation, and systems (01-02-2024)“…To effectively implement condition-based maintenance for the air compressor in a railway vehicle, a thorough understanding of its fault characteristics and the…”
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Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy
Published in The Journal of clinical investigation (01-10-2019)“…Brain somatic mutations confer genomic diversity in the human brain and cause neurodevelopmental disorders. Recently, brain somatic activating mutations in…”
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Analysis of low-level somatic mosaicism reveals stage and tissue-specific mutational features in human development
Published in PLoS genetics (19-09-2022)“…Most somatic mutations that arise during normal development are present at low levels in single or multiple tissues depending on the developmental stage and…”
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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
Published in Nature communications (25-10-2016)“…X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a progressive neurodegenerative disorder associated with the accumulation of very…”
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Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
Published in Cell (10-04-2014)“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and…”
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Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms
Published in Nature communications (11-10-2021)“…The chromatin remodeler RSF1 enriched at mitotic centromeres is essential for proper chromosome alignment and segregation and underlying mechanisms remain to…”
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