Search Results - "Chujo, Takeshi"

Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications by Chujo, Takeshi, Tomizawa, Kazuhito

“…tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes. Although composed of different chemistries, more than 40 types of human tRNA…”
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Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs by Chujo, Takeshi, Suzuki, Tsutomu

“…In human mitochondria, 1-methyladenosine (m¹A) occurs at position 58 of tRNA(Leu(UUR)). In addition, partial m¹A58 modifications have been found in human…”
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Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function by Chujo, Takeshi, Hirose, Tetsuro

“…Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis,…”
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Unusual semi‐extractability as a hallmark of nuclear body‐associated architectural noncoding RNAs by Chujo, Takeshi, Yamazaki, Tomohiro, Kawaguchi, Tetsuya, Kurosaka, Satoshi, Takumi, Toru, Nakagawa, Shinichi, Hirose, Tetsuro

“…NEAT1_2 long noncoding RNA (lncRNA) is the molecular scaffold of paraspeckle nuclear bodies. Here, we report an improved RNA extraction method: extensive…”
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Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization by West, Jason A, Mito, Mari, Kurosaka, Satoshi, Takumi, Toru, Tanegashima, Chiharu, Chujo, Takeshi, Yanaka, Kaori, Kingston, Robert E, Hirose, Tetsuro, Bond, Charles, Fox, Archa, Nakagawa, Shinichi

“…Paraspeckles are nuclear bodies built on the long noncoding RNA Neat1, which regulates a variety of physiological processes including cancer progression and…”
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FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression by Hirayama, Mayumi, Wei, Fan-Yan, Chujo, Takeshi, Oki, Shinya, Yakita, Maya, Kobayashi, Daiki, Araki, Norie, Takahashi, Nozomu, Yoshida, Ryoji, Nakayama, Hideki, Tomizawa, Kazuhito

“…N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation…”
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Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates by Bar-Yaacov, Dan, Frumkin, Idan, Yashiro, Yuka, Chujo, Takeshi, Ishigami, Yuma, Chemla, Yonatan, Blumberg, Amit, Schlesinger, Orr, Bieri, Philipp, Greber, Basil, Ban, Nenad, Zarivach, Raz, Alfonta, Lital, Pilpel, Yitzhak, Suzuki, Tsutomu, Mishmar, Dan

“…The mitochondrial ribosome, which translates all mitochondrial DNA (mtDNA)-encoded proteins, should be tightly regulated pre- and post-transcriptionally…”
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Remarkable improvement in detection of readthrough downstream-of-gene transcripts by semi-extractable RNA-sequencing by Iwakiri, Junichi, Tanaka, Kumiko, Chujo, Takeshi, Takakuwa, Hiro, Yamazaki, Tomohiro, Terai, Goro, Asai, Kiyoshi, Hirose, Tetsuro

“…The mammalian cell nucleus contains dozens of membrane-less nuclear bodies that play significant roles in various aspects of gene expression. Several nuclear…”
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The TDRD9-MIWI2 Complex Is Essential for piRNA-Mediated Retrotransposon Silencing in the Mouse Male Germline by Shoji, Masanobu, Tanaka, Takashi, Hosokawa, Mihoko, Reuter, Michael, Stark, Alexander, Kato, Yuzuru, Kondoh, Gen, Okawa, Katsuya, Chujo, Takeshi, Suzuki, Tsutomu, Hata, Kenichiro, Martin, Sandra L., Noce, Toshiaki, Kuramochi-Miyagawa, Satomi, Nakano, Toru, Sasaki, Hiroyuki, Pillai, Ramesh S., Nakatsuji, Norio, Chuma, Shinichiro

“…Host-defense mechanisms against transposable elements are critical to protect the genome information. Here we show that tudor-domain containing 9 ( Tdrd9) is…”
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Regulation of growth hormone biosynthesis by Cdk5 regulatory subunit associated protein 1-like 1 (CDKAL1) in pituitary adenomas by Takesue, Yoshihiro, Wei, Fan-Yan, Fukuda, Hiroyuki, Tanoue, Yuki, Yamamoto, Takahiro, Chujo, Takeshi, Shinojima, Naoki, Yano, Shigetoshi, Morioka, Motohiro, Mukasa, Akitake, Kuratsu, Junichi, Tomizawa, Kazuhito

“…CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tRNA-modifying enzyme that catalyzes 2-methylthiolation (ms2) and has been implicated in the…”
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Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication by Fukuda, Hiroyuki, Chujo, Takeshi, Wei, Fan-Yan, Shi, Sheng-Lan, Hirayama, Mayumi, Kaitsuka, Taku, Yamamoto, Takahiro, Oshiumi, Hiroyuki, Tomizawa, Kazuhito

“…Abstract Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A…”
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Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function by Chujo, Takeshi, Hirose, Tetsuro

“…Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis,…”
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Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats by Oka, Kaori, Fujioka, Shusuke, Kawamura, Yoshimi, Komohara, Yoshihiro, Chujo, Takeshi, Sekiguchi, Koki, Yamamura, Yuki, Oiwa, Yuki, Omamiuda-Ishikawa, Natsuko, Komaki, Shohei, Sutoh, Yoichi, Sakurai, Satoko, Tomizawa, Kazuhito, Bono, Hidemasa, Shimizu, Atsushi, Araki, Kimi, Yamamoto, Takuya, Yamada, Yasuhiro, Oshiumi, Hiroyuki, Miura, Kyoko

“…Naked mole-rats (NMRs) have a very low spontaneous carcinogenesis rate, which has prompted studies on the responsible mechanisms to provide clues for human…”
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LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria by Chujo, Takeshi, Ohira, Takayuki, Sakaguchi, Yuriko, Goshima, Naoki, Nomura, Nobuo, Nagao, Asuteka, Suzuki, Tsutomu

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Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation by Matsuura, Jin, Akichika, Shinichiro, Wei, Fan-Yan, Suzuki, Tsutomu, Yamamoto, Takahiro, Watanabe, Yuka, Valášek, Leoš Shivaya, Mukasa, Akitake, Tomizawa, Kazuhito, Chujo, Takeshi

“…Human cytoplasmic tRNAs contain dihydrouridine modifications at positions 16 and 17 (D16/D17). The enzyme responsible for D16/D17 formation and its cellular…”
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NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice by Murakami, Yoshitaka, Wei, Fan-Yan, Kawamura, Yoshimi, Horiguchi, Haruki, Kadomatsu, Tsuyoshi, Miyata, Keishi, Miura, Kyoko, Oike, Yuichi, Ando, Yukio, Ueda, Mitsuharu, Tomizawa, Kazuhito, Chujo, Takeshi

“…In mammalian mitochondria, translation of the AUA codon is supported by 5-formylcytidine (f 5 C) modification in the mitochondrial methionine tRNA anticodon…”
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t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and Severity by Nagayoshi, Yu, Nishiguchi, Kayo, Yamamura, Ryosuke, Chujo, Takeshi, Oshiumi, Hiroyuki, Nagata, Hiroko, Kaneko, Hitomi, Yamamoto, Keiichi, Nakata, Hirotomo, Sakakida, Korin, Kunisawa, Akihiro, Adachi, Masataka, Kakizoe, Yutaka, Mizobe, Takanori, Kuratsu, Jun-ichi, Shimada, Shinya, Nakamori, Yasushi, Matsuoka, Masao, Mukoyama, Masashi, Wei, Fan-Yan, Tomizawa, Kazuhito

“…SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing modified nucleosides into…”
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Correction: Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates by Bar-Yaacov, Dan, Frumkin, Idan, Yashiro, Yuka, Chujo, Takeshi, Ishigami, Yuma, Chemla, Yonatan, Blumberg, Amit, Schlesinger, Orr, Bieri, Philipp, Greber, Basil, Ban, Nenad, Zarivach, Raz, Alfonta, Lital, Pilpel, Yitzhak, Suzuki, Tsutomu, Mishmar, Dan

“…[This corrects the article DOI: 10.1371/journal.pbio.1002557.]…”
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A Small Chip Area Stochastic Calibration for TDC Using Ring Oscillator by Katoh, Kentaroh, Kobayashi, Yutaro, Chujo, Takeshi, Wang, Junshan, Li, Ensi, Li, Congbing, Kobayashi, Haruo

“…This paper proposes a small chip area stochastic calibration for TDC linearity and input range, and analyzes it with FPGA. The proposed calibration estimates…”
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Architectural RNAs (arcRNAs): A class of long noncoding RNAs that function as the scaffold of nuclear bodies by Chujo, Takeshi, Yamazaki, Tomohiro, Hirose, Tetsuro

“…Mammalian transcriptome analyses elucidated the presence of thousands of unannotated long noncoding RNAs (lncRNAs) with distinct transcriptional units…”
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