Search Results - "Chudinov, Mikhail"

Nucleoside Analogs with Fleximer Nucleobase by Chudinov, Mikhail V.

“…This review article is devoted to the so-called fleximer nucleoside analogs, containing two or more planar moieties in the heterocyclic base, connected by a…”
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Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents by Lukin, Alexei, Chudinov, Mikhail, Vedekhina, Tatiana, Rogacheva, Elizaveta, Kraeva, Lyudmila, Bakulina, Olga, Krasavin, Mikhail

“…The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives…”
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5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens by Rogacheva, Elizaveta, Kraeva, Lyudmila, Lukin, Alexey, Vinogradova, Lyubov, Komarova, Kristina, Chudinov, Mikhail, Gureev, Maxim, Chupakhin, Evgeny

“…A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing…”
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Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity by Vinogradova, Lyubov, Lukin, Alexey, Komarova, Kristina, Zhuravlev, Maxim, Fadeev, Artem, Chudinov, Mikhail, Rogacheva, Elizaveta, Kraeva, Lyudmila, Gureev, Maxim, Porozov, Yuri, Dogonadze, Marine, Vinogradova, Tatiana

“…A series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc…”
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Scaffold hopping in the oxadiazole antibiotic structure leads to more active compounds by Vinogradova, Lyubov V., Komarova, Kristina Yu, Chudinov, Mikhail V., Rogacheva, Elizaveta V., Kraeva, Lyudmila A., Lukin, Alexey Yu

“…[Display omitted] Isosteric replacement of the oxadiazole ring by amide bond in the structure of new non-β-lactam antibiotics led to compounds with higher…”
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The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis by Komarova, Kristina, Vinogradova, Lyubov, Lukin, Alexey, Zhuravlev, Maxim, Deniskin, Dmitry, Chudinov, Mikhail, Gureev, Maxim, Dogonadze, Marine, Zabolotnykh, Natalia, Vinogradova, Tatiana, Lavrova, Anastasia, Yablonskiy, Petr

“…A series of 21 new 7'H-spiro[azetidine-3,5'-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed…”
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Isosteric ribavirin analogues: Synthesis and antiviral activities by Zhurilo, Nikolay I., Chudinov, Mikhail V., Matveev, Andrey V., Smirnova, Olga S., Konstantinova, Irina D., Miroshnikov, Anatoly I., Prutkov, Alexander N., Grebenkina, Lyubov E., Pulkova, Natalya V., Shvets, Vitaly I.

“…[Display omitted] The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against…”
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Parallel synthesis of derivatives of 1H-1,2,4-triazole-3-carboxylic acids with heterocyclic substituents at position 5 by Grebenkina, Lyubov E., Matveev, Andrey V., Chudinov, Mikhail V.

“…A mild universal method for the synthesis of derivatives of 5-substituted 1 H -1,2,4-triazole-3-carboxylic acids from a single precursor, ethyl β- N…”
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The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof by Komarova, Kristina Yu, Lukin, Alexey Yu, Vinogradova, Lyubov V., Zhuravlev, Maxim E., Dogonadze, Marine Z., Vinogradova, Tatiana I., Gureev, Maxim A., Chudinov, Mikhail V., Dar’in, Dmitry V.

“…The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M . tu- berculosis containing…”
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Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists by Lukin, Alexey, Bakholdina, Anna, Chudinov, Mikhail, Onopchenko, Oleksandra, Zhuravel, Elena, Zozulya, Sergey, Gureev, Maxim, Krasavin, Mikhail

“…A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free…”
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5-alkylvinyl-1,2,4-triazole nucleosides: Synthesis and biological evaluation by Prutkov, Alexander N., Chudinov, Mikhail V., Matveev, Andrey V., Grebenkina, Lyubov E., Akimov, Mikhail G., Berezovskaya, Yulia V.

“…Some 5-substituted ribavirin analogues have a high antiviral and anticancer activity, but their mechanisms of action are obviously not the same as their parent…”
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Chemical ribosylation of 5-substituted 1,2,4-triazole-3-carboxylates by Prutkov, Alexander N., Chudinov, Mikhail V., Matveev, Andrey V., Grebenkina, Lyubov E., Berezovskaya, Yulia V.

“…The chemical ribosylation pathways of 5-substituted-1,2,4-triazole-3-carboxylates are discussed. For the products of the chemical synthesis of the 3(5)-alkyl-…”
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Chemo-enzymatic synthesis of 5-substituted ribavirin analogs: Unexpected cooperative effect in the interaction of 5-alkyloxymethyl 1,2,4-triazol-3-carboxamides with E. coli purine nucleoside phosphorylase active site by Smirnova, Olga S., Berzina, Maria Ya, Fateev, Ilya V., Eletskaya, Barbara Z., Kostromina, Maria A., Kaushin, Alexey L., Paramonov, Alexander S., Prutkov, Alexander N., Matveev, Andrey V., Grebenkina, Lyubov E., Chudinov, Mikhail V., Andronova, Valeria L., Galegov, Georgiy A., Deryabin, Petr G., Miroshnikov, Anatoly I., Esipov, Roman S., Konstantinova, Irina D.

“…A series of 5-alkyl/aryl-oxymethyl-ribavirin analogs was synthesized. Surprisingly, ability of E. coli purine nucleoside phosphorylase (PNP) to synthesize…”
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An alternative route to the arylvinyltriazole nucleosides by Chudinov, Mikhail V., Prutkov, Alexander N., Matveev, Andrey V., Grebenkina, Lyubov E., Konstantinova, Irina D., Berezovskaya, Yulia V.

“…[Display omitted] A new pathway to synthesis of arylvinyl ribavirin analogues is developed which makes it possible to obtain not only trans- but also…”
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Optimization of Antiviral Prodrug Properties Using Combinatorial Methods by Berezovskaya, Yulia V., Chudinov, Mikhail V., Yurkevich, Alexander M.

“…Some diacid biodegradable synthesis of aziduthymidine (AZT) were synthesized and applied to production of about 60 different derivatives…”
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Design and synthesis of 4-nitroimidazole derivatives with potential antitubercular activity by Vedekhina, T. S., Chudinov, M. V., Lukin, A. Yu

“…Objectives. To develop the procedures for synthesis of hybrid molecules with potential anti-tubercular activity containing heterocyclic cores of…”
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Novel 5-alkyl(aryl)-substituted ribavirine analogues: synthesis and antiviral evaluation by Chudinov, Mikhail V., Matveev, Andrey V., Prutkov, Alexander N., Konstantinova, Irina D., Fateev, Ilja V., Prasolov, Vladimir S., Smirnova, Olga A., Ivanov, Alexander V., Galegov, Georgy A., Deryabin, Petr G.

“…[Display omitted] Novel 5-alkyl(aryl)-substituted 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamides were prepared in three steps. Their antiviral activity was…”
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Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists by Lukin, Alexey, Bakholdina, Anna, Chudinov, Mikhail, Onopchenko, Oleksandra, Zhuravel, Elena, Zozulya, Sergey, Gureev, Maxim, Krasavin, Mikhail

“…A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free…”
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