Search Results - "Chudasama, Vijay"

Advances in targeting the folate receptor in the treatment/imaging of cancers by Fernández, Marcos, Javaid, Faiza, Chudasama, Vijay

“…The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression on a large number of tumours. Consequently, the FR has been…”
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Recent advances in the construction of antibody–drug conjugates by Chudasama, Vijay, Maruani, Antoine, Caddick, Stephen

“…Antibody–drug conjugates have shown considerable promise for treating disease. However, in order to deliver their full potential, sophisticated site-specific…”
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Antibody fragments as nanoparticle targeting ligands: a step in the right direction by Richards, Daniel A, Maruani, Antoine, Chudasama, Vijay

“…Recent advances in nanomedicine have shown that dramatic improvements in nanoparticle therapeutics and diagnostics can be achieved through the use of disease…”
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The renaissance of chemically generated bispecific antibodies by Szijj, Peter, Chudasama, Vijay

“…Bispecific antibodies (bsAbs) target two different epitopes. These are an up-and-coming class of biologics, with two such therapeutics (emicizumab and…”
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Tyrosine bioconjugation - an emergent alternative by Szijj, Peter A, Kostadinova, Kristina A, Spears, Richard J, Chudasama, Vijay

“…Protein bioconjugation is an increasingly important field of research, with wide-ranging applications in areas such as therapeutics and biomaterials…”
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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy by Maruani, Antoine, Smith, Mark E.B., Miranda, Enrique, Chester, Kerry A., Chudasama, Vijay, Caddick, Stephen

“…Although recent methods for the engineering of antibody–drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction,…”
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Motional timescale predictions by molecular dynamics simulations: Case study using proline and hydroxyproline sidechain dynamics by Aliev, Abil E., Kulke, Martin, Khaneja, Harmeet S., Chudasama, Vijay, Sheppard, Tom D., Lanigan, Rachel M.

“…ABSTRACT We propose a new approach for force field optimizations which aims at reproducing dynamics characteristics using biomolecular MD simulations, in…”
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Dual modification of biomolecules by Maruani, Antoine, Richards, Daniel A, Chudasama, Vijay

“…With the advent of novel bioorthogonal reactions and "click" chemistry, an increasing number of strategies for the single labelling of proteins and…”
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Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic by Maruani, Antoine, Savoie, Huguette, Bryden, Francesca, Caddick, Stephen, Boyle, Ross, Chudasama, Vijay

“…Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant…”
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Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC) by Nunes, João P M, Morais, Maurício, Vassileva, Vessela, Robinson, Eifion, Rajkumar, Vineeth S, Smith, Mark E B, Pedley, R Barbara, Caddick, Stephen, Baker, James R, Chudasama, Vijay

“…Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging…”
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Photoimmunotherapy Using Cationic and Anionic Photosensitizer-Antibody Conjugates against HIV Env-Expressing Cells by Sadraeian, Mohammad, Bahou, Calise, da Cruz, Edgar Ferreira, Janini, Luíz Mário Ramos, Sobhie Diaz, Ricardo, Boyle, Ross W, Chudasama, Vijay, Eduardo Gontijo Guimarães, Francisco

“…Different therapeutic strategies have been investigated to target and eliminate HIV-1-infected cells by using armed antibodies specific to viral proteins, with…”
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Employing defined bioconjugates to generate chemically functionalised gold nanoparticles for in vitro diagnostic applications by Richards, Daniel A, Thomas, Michael R, Szijj, Peter A, Foote, James, Chen, Yiyun, Nogueira, João C F, Chudasama, Vijay, Stevens, Molly M

“…Novel methods for introducing chemical and biological functionality to the surface of gold nanoparticles serve to increase the utility of this class of…”
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Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment by Bryden, Francesca, Maruani, Antoine, Savoie, Huguette, Chudasama, Vijay, Smith, Mark E. B, Caddick, Stephen, Boyle, Ross W

“…The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of…”
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Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer by Greene, Michelle K., Chen, Ting, Robinson, Eifion, Straubinger, Ninfa L., Minx, Charlene, Chan, Darren K. W., Wang, Jun, Burrows, James F., Van Schaeybroeck, Sandra, Baker, James R., Caddick, Stephen, Longley, Daniel B., Mager, Donald E., Straubinger, Robert M., Chudasama, Vijay, Scott, Christopher J.

“…Background Antibody-drug conjugate (ADC) construction poses numerous challenges that limit clinical progress. In particular, common bioconjugation methods…”
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Assembly of High-Potency Photosensitizer–Antibody Conjugates through Application of Dendron Multiplier Technology by Bryden, Francesca, Maruani, Antoine, Rodrigues, João M. M, Cheng, Miffy H. Y, Savoie, Huguette, Beeby, Andrew, Chudasama, Vijay, Boyle, Ross W

“…Exploitation of photosensitizers as payloads for antibody-based anticancer therapeutics offers a novel alternative to the small pool of commonly utilized…”
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Optical control of trimeric P2X receptors and acid-sensing ion channels by Browne, Liam E., Nunes, João P. M., Sim, Joan A., Chudasama, Vijay, Bragg, Laricia, Caddick, Stephen, North, R. Alan

“…P2X receptors are trimeric membrane proteins that function as ion channels gated by extracellular ATP. We have engineered a P2X2 receptor that opens within…”
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Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation by Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F, Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A, Baker, James R, Smith, Mark E B, Caddick, Stephen

“…In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain…”
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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation by Morgan, Rachel E, Chudasama, Vijay, Moody, Paul, Smith, Mark E B, Caddick, Stephen

“…Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital…”
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A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine by Smith, Mark E B, Caspersen, Mikael B, Robinson, Eifion, Morais, Maurício, Maruani, Antoine, Nunes, João P M, Nicholls, Karl, Saxton, Malcolm J, Caddick, Stephen, Baker, James R, Chudasama, Vijay

“…Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine…”
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Formation of Synthetically Versatile 2‑Aminobenzophenones from Readily Accessed Acyl Hydrazides by Ahmed, Nehaal, Shamsabadi, André, Chudasama, Vijay

“…Herein, we report the transformation of readily accessed acyl hydrazides into protected 2-aminobenzophenones via a two-step process involving an aryne-based…”
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