Search Results - "Chuckowree, Jyoti"

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window by Holtmaat, Anthony, De Paola, Vincenzo, Hübener, Mark, Knott, Graham, Nedivi, Elly, Portera-Cailliau, Carlos, Trachtenberg, Joshua T, Bonhoeffer, Tobias, Chow, David K, Chuckowree, Jyoti, Hofer, Sonja B, Keck, Tara, Lee, Wei-Chung A, Mostany, Ricardo, Mrsic-Flogel, Tom D, Svoboda, Karel, Wilbrecht, Linda

“…To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons and their synapses need to be studied in the intact brain over…”
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A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease by Clark, Jayden A, Yeaman, Elise J, Blizzard, Catherine A, Chuckowree, Jyoti A, Dickson, Tracey C

“…Amyotrophic lateral sclerosis (ALS) is an aggressive multifactorial disease converging on a common pathology: the degeneration of motor neurons (MNs), their…”
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The pathologic outcomes and efficacy of epothilone treatment following traumatic brain injury is determined by age by Zhu, Zhendan, Chuckowree, Jyoti A., Musgrove, Ruth, Dickson, Tracey C., Blizzard, Catherine A.

“…Traumatic brain injury (TBI) can affect individuals at any age, with the potential of causing lasting neurologic consequences. The lack of effective…”
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Mild Traumatic Brain Injury Leads to Decreased Inhibition and a Differential Response of Calretinin Positive Interneurons in the Injured Cortex by Brizuela, Mariana, Blizzard, Catherine A, Chuckowree, Jyoti A, Pitman, Kimberley A, Young, Kaylene M, Dickson, Tracey

“…It is clear that even mild forms of traumatic brain injury (TBI) can have lasting cognitive effects; however, the specific cellular changes responsible for the…”
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Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43A315T Mouse Model of Amyotrophic Lateral Sclerosis by Handley, Emily E., Reale, Laura A., Chuckowree, Jyoti A., Dyer, Marcus S., Barnett, Grace L., Clark, Courtney M., Bennett, William, Dickson, Tracey C., Blizzard, Catherine A.

“…Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex function affected early in disease. Younger females have a lower…”
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The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro by Brizuela, Mariana, Blizzard, Catherine A., Chuckowree, Jyoti A., Dawkins, Edgar, Gasperini, Robert J., Young, Kaylene M., Dickson, Tracey C.

“…Neuronal cytoskeletal alterations, in particular the loss and misalignment of microtubules, are considered a hallmark feature of the degeneration that occurs…”
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The Microtubule-Modulating Drug Epothilone D Alters Dendritic Spine Morphology in a Mouse Model of Mild Traumatic Brain Injury by Chuckowree, Jyoti A, Zhu, Zhendan, Brizuela, Mariana, Lee, Ka M, Blizzard, Catherine A, Dickson, Tracey C

“…Microtubule dynamics underpin a plethora of roles involved in the intricate development, structure, function, and maintenance of the central nervous system…”
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Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it? by Clark, Jayden, Zhu, Zhendan, Chuckowree, Jyoti, Dickson, Tracey, Blizzard, Catherine

“…Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive…”
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Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice by Clark, Rosemary M., Clark, Courtney M., Lewis, Katherine E.A., Dyer, Marcus S., Chuckowree, Jyoti A., Hoyle, Joshua A., Blizzard, Catherine A., Dickson, Tracey C.

“…Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In…”
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Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS by Clark, Courtney M., Clark, Rosemary M., Hoyle, Joshua A., Chuckowree, Jyoti A., McLean, Catriona A., Dickson, Tracey C.

“…Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While…”
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Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system by Vickers, James C, King, Anna E, Woodhouse, Adele, Kirkcaldie, Matthew T, Staal, Jerome A, McCormack, Graeme H, Blizzard, Catherine A, Musgrove, Ruth E.J, Mitew, Stanislaw, Liu, Yao, Chuckowree, Jyoti A, Bibari, Olivier, Dickson, Tracey C

“…Abstract There has been growing interest in the axon as the initial focus of pathological change in a number of neurodegenerative diseases of the central…”
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Cytoskeletal and Morphological Alterations Underlying Axonal Sprouting after Localized Transection of Cortical Neuron Axons In Vitro by Chuckowree, Jyoti A, Vickers, James C

“…We examined the cytoskeletal dynamics that characterize neurite sprouting after axonal injury to cortical neurons maintained in culture for several weeks and…”
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Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity by Blizzard, Catherine A, Chuckowree, Jyoti A, King, Anna E, Hosie, Katherine A, McCormack, Graeme H, Chapman, Jamie A, Vickers, James C, Dickson, Tracey C

“…Accumulating evidence indicates that damage to the adult mammalian brain evokes an array of adaptive cellular responses and may retain a capacity for…”
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Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy by Chung, Roger S, Staal, Jerome A, McCormack, Graeme H, Dickson, Tracey C, Cozens, Mark A, Chuckowree, Jyoti A, Quilty, Marian C, Vickers, James C

“…We report a new model of transient axonal stretch injury involving pressurized fluid deflection of bundles of axons, resulting in a transient 1-6% increase in…”
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α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the β-amyloid plaques in inducing neuronal injury by Dickson, Tracey C., Chuckowree, Jyoti A., Inn Chuah, Meng, West, Adrian K., Vickers, James C.

“…This study investigated the role of α-internexin in the neuronal alterations associated with β-amyloid plaque formation in Alzheimer's disease (AD). Cortical…”
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Intrinsic Regenerative Ability of Mature CNS Neurons by Chuckowree, Jyoti A., Dickson, Tracey C., Vickers, James C.

“…A prevailing view in neuroscience is that the mature CNS has relatively little capacity to respond adaptively to injury. Recent data indicating a high degree…”
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Does beta-amyloid plaque formation cause structural injury to neuronal processes? by Woodhouse, Adele, West, Adrian K, Chuckowree, Jyoti A, Vickers, James C, Dickson, Tracey C

“…The precise role of beta-amyloid plaque formation in the cascade of brain cell changes that lead to neurodegeneration and dementia in Alzheimer's disease has…”
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Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43 A315T Mouse Model of Amyotrophic Lateral Sclerosis by Handley, Emily E, Reale, Laura A, Chuckowree, Jyoti A, Dyer, Marcus S, Barnett, Grace L, Clark, Courtney M, Bennett, William, Dickson, Tracey C, Blizzard, Catherine A

“…Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex function affected early in disease. Younger females have a lower…”
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Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer by Chin, Suyin Paulynn, Marthick, James R., West, Alison C., Short, Annabel K., Chuckowree, Jyoti, Polanowski, Andrea M., Thomson, Russell J., Holloway, Adele F., Dickinson, Joanne L.

“…BACKGROUND Integrin alpha2 beta1 (α2β1) plays an integral role in tumour cell invasion, metastasis and angiogenesis, and altered expression of the receptor has…”
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Identification and characterization of a population of motile neurons in long-term cortical culture by Haas, Matilda A., Chuckowree, Jyoti A., Chung, Roger S., Vickers, James C., Dickson, Tracey C.

“…The specific phenotypes and progression to maturity of primary cortical neurons in long‐term culture correlate well with neurons in vivo. Utilizing a model of…”
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