Factors affecting the efficacy of gemcitabine and nab-paclitaxel (paclitaxel + albumin) combination in the Russian patient population: results of a multicenter retrospective study

Factors affecting the efficacy of gemcitabine and nab-paclitaxel (paclitaxel + albumin) combination in the Russian patient population: results of a multicenter retrospective study

Introduction. The randomized MPACT study showed that nab-paclitaxel plus gemcitabine results in statistically significantly longer life expectancy. The objective of this retrospective study is to obtain relevant data on the efficacy of this combination in real clinical practice in Russia. Materials...

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Published in:Medicinskij sovet no. 19; pp. 74 - 82
Main Authors: Pokataev, I. A., Lyadova, M. A., Fedyanin, M. Yu, Tryakin, A. A., Chubenko, V. F., Moiseenko, F. V., Zagorskaya, L. A., Stepanova, M. L., Androsova, A. V., Nosov, D. A., Karpova, N. V., Kit, O. I., Vladimirova, L. Yu, Popova, I. L., Belonogov, A. V., Ponomarenko, D. M., Yukalchuk, D. Yu, Shikina, V. E., Ivanova, N. V., Khasanova, A. I., Kruglov, A. D., Stradaeva, I. Yu, Perepletova, A. S., Filippova, V. M., Buzova, N. L., Khavaneva, O. V., Musaeva, Kh. S., Goryainova, A. Yu, Romanchuk, O. V., Tespizhek, I. Sh, Tyulyandin, S. A.
Format: Journal Article
Language:English
Russian
Published: Remedium Group LLC 09-12-2019
Subjects:
chemotherapy
gemcitabine
nab-paclitaxel
pancreatic cancer
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Summary:Introduction. The randomized MPACT study showed that nab-paclitaxel plus gemcitabine results in statistically significantly longer life expectancy. The objective of this retrospective study is to obtain relevant data on the efficacy of this combination in real clinical practice in Russia. Materials and methods. The study included patients with morphologically proven locally advanced or metastatic pancreatic cancer, with a general condition assessed on the ECOG scale between 0-2, which received gemcitabine and nab-paclitaxel. Immediate and long-term treatment outcomes were evaluated. Results. 142 patients, who received treatment from 2009 to 2019 in 17 centers from 11 regions of Russia, were included in the study. Assessment of the objective effect was made in 134 patients. Objective effects were detected in 34 (25.4%) cases. The median time-to-progression was 6.1 months (95% confidence interval (CI) 4.8-7.4),  the median length of life was 14.2 months (95% CI 10.6-17.9). An elevated CA19-9 level is the only independent adverse prognostic factor for progression-free survival (RR = 8.0, 95% CI 1.4 -43.8, p = 0.02) according to Cox multivariate regression analysis. The number of previously conducted chemotherapy lines (p = 0.34), ECOG status (p = 0.70), age over 70 years (p = 0.45), serious comorbidity (p = 0.97) did not have a statistically significant effect on progression-free survival. Findings. The gemcitabine and nab-paclitaxel combination has a relatively higher efficacy in advanced pancreatic cancer. The immediate and long-term results of its use in real clinical practice in Russia are consistent with data obtained in the Western countries.
ISSN:2079-701X
2658-5790
DOI:10.21518/2079-701X-2019-19-74-82