Search Results - "Chuanlai Shen"

Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine Design by Mei, Xueyin, Gu, Pan, Shen, Chuanlai, Lin, Xue, Li, Jian

“…Since the first outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, its high…”
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Comparison of HBV-specific T cell reactivity across the pregnant, postpartum and non-pregnant women with chronic HBV infection by Wang, Genju, Yue, Fangping, Zhang, Ziyue, Wu, Yandan, Ji, Ruixue, Zhou, Guanlun, Ji, Ying, Shen, Chuanlai

“…To investigate the features of HBV-specific T cell reactivity across the pregnant, postpartum or non-pregnant women with chronic HBV infection. A total of 283…”
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The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules by Mei, Xueyin, Li, Xingyu, Zhao, Chen, Liu, Anna, Ding, Yan, Shen, Chuanlai, Li, Jian

“…Chronic hepatitis B virus (HBV), a potentially life-threatening liver disease, makes people vulnerable to serious diseases such as cancer. T lymphocytes play a…”
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A Systematic Review of T Cell Epitopes Defined from the Proteome of Hepatitis B Virus by Wu, Yandan, Ding, Yan, Shen, Chuanlai

“…Hepatitis B virus (HBV) infection remains a worldwide health problem and no eradicative therapy is currently available. Host T cell immune responses have…”
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Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay by Wu, Yandan, Liu, Xiaotao, Mao, Yuan, Ji, Ruixue, Xia, Lingzhi, Zhou, Zining, Ding, Yan, Li, Pinqing, Zhao, Yu, Peng, Min, Qiu, Jie, Shen, Chuanlai

“…The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort…”
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A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide-Autoreactive CD4 + and CD8 + T Cells by Wan, Xin, Pei, Weiya, Shahzad, Khawar Ali, Zhang, Lei, Song, Shilong, Jin, Xiaoxiao, Wang, Limin, Zhao, Chen, Shen, Chuanlai

“…In this study, a tolerogenic artificial APC (TaAPC) was developed to directly and selectively modulate myelin-autoreactive CD4 and CD8 T cells in the myelin…”
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Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8+ T cell responses in HLA-A transgenic mice by Jin, Xiaoxiao, Ding, Yan, Sun, Shihui, Wang, Xinyi, Zhou, Zining, Liu, Xiaotao, Li, Miaomiao, Chen, Xian, Shen, Anran, Wu, Yandan, Liu, Bicheng, Zhang, Jianqiong, Li, Jian, Yang, Yi, Qiu, Haibo, Shen, Chuanlai, He, Yuxian, Zhao, Guangyu

“…Since severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific T cells have been found to play essential roles in host immune protection and…”
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Screening and Identification of HBV Epitopes Restricted by Multiple Prevalent HLA-A Allotypes by Ding, Yan, Zhou, Zining, Li, Xingyu, Zhao, Chen, Jin, Xiaoxiao, Liu, Xiaotao, Wu, Yandan, Mei, Xueyin, Li, Jian, Qiu, Jie, Shen, Chuanlai

“…Although host T cell immune responses to hepatitis B virus (HBV) have been demonstrated to have important influences on the outcome of HBV infection, the…”
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Screening of Efficient Adjuvants for the RBD-Based Subunit Vaccine of SARS-CoV-2 by Shi, Juan, Zhao, Yu, Peng, Min, Zhu, Suyue, Wu, Yandan, Ji, Ruixue, Shen, Chuanlai

“…The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more transmissible, with a reduced sensitivity to vaccines targeting the…”
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On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation by Shahzad, Khawar Ali, Wan, Xin, Zhang, Lei, Pei, Weiya, Zhang, Aifeng, Younis, Muhammad, Wang, Wei, Shen, Chuanlai

“…Biomimetic nanoparticles have been reported as immune modulators in autoimmune diseases and allograft rejections by numerous researchers. However, most of the…”
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Effects of Adjuvants on the Immunogenicity and Efficacy of a Zika Virus Envelope Domain III Subunit Vaccine by Wang, Xinyi, Tai, Wanbo, Zhang, Xiaolu, Zhou, Yusen, Du, Lanying, Shen, Chuanlai

“…Zika virus (ZIKV), a mosquito-borne flavivirus, has attracted global attention due to its close association with congenital Zika syndrome and neurological…”
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Cancer Immunotherapy: Theory and Application by Chen, Guobing, Bodogai, Monica, Tamehiro, Norimasa, Shen, Chuanlai, Dou, Jun

“…Through either strengthening the host immune responses against tumors, supplying modified immune system components, or counteracting signals produced by cancer…”
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Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice by Shi, Juan, Jin, Xiaoxiao, Ding, Yan, Liu, Xiaotao, Shen, Anran, Wu, Yandan, Peng, Min, Shen, Chuanlai

“…Multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have spread around the world, but the neutralizing effects of antibodies…”
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An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8 + T Cells by Wang, Wei, Shahzad, Khawar Ali, Li, Miaochen, Zhang, Aifeng, Zhang, Lei, Xu, Tao, Wan, Xin, Shen, Chuanlai

“…Selectively depleting the pathogenic T cells is a fundamental strategy for the treatment of allograft rejection and autoimmune disease since it retains the…”
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A Combination Strategy for Construction of Peptide-β2m-H-2Kb Single Chain with Overlap Extension PCR and One-Step Cloning by Tao Xu, Xiaoe Li, You Wu, Khawar Ali Shahzad, Wei Wang, Lei Zhang, Chuanlai Shen

“…The time-consuming and high-cost preparation of soluble peptide-major histocompatibility complexes (pMHC) currently limits their wide uses in monitoring…”
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Downregulation of HLA Class I Molecules in Primary Oral Squamous Cell Carcinomas and Cell Lines by Tang, Qiusha, Zhang, Jianqiong, Qi, Bing, Shen, Chuanlai, Xie, Wei

“…Background and Aims Loss or downregulation of human leukocyte antigen (HLA) class I expression has been reported in a variety of human tumors including oral…”
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Characterization of MHC/peptide complexes refolded by a one-step ion-exchange chromatography by Shen, Chuanlai, He, Yong, Meng, Fanyan, Cheng, Kai, Zhang, Daoping, Miao, Fengqin, Zhang, Jianqiong

“…The current refolding process of MHC/peptide complexes is low-yield and time-consuming, thereby limiting the wide uses of MHC/peptide multimers. Here the heavy…”
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Cloning and expression of three peptide-linked β2-microglobulin molecules in Escherichia coli with an isocaudamer technique by Meng, Fanyan, Shen, Chuanlai, He, Yong, Miao, Fengqin, Zhang, Jianqiong

“…The application of the peptide-linked β2-microglobulin (β2m) strategy is limited in some cases due to the incompatibility between the sequences of the peptides…”
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Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection by Shen, Chuanlai, Hu, Ting, Shen, Ling, Gao, Lei, Xie, Wei, Zhang, Jianqiong

“…Background and Aim:  The interferon sensitivity determining region (ISDR) in the non‐structural 5A protein (NS5A) gene of hepatitis C virus genotype 1b…”
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A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2 by Jin, Xiaoxiao, Liu, Xiaotao, Shen, Chuanlai

“…•A systemic review of T cell epitopes of SARS-CoV-2 proteome.•The HLA restriction of defined T cell epitopes of SARS-CoV-2.•The methods identifying the T cell…”
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