Search Results - "Chu, Zhaoxing"

Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3‑Kinase Inhibitors as a Promising Strategy for Cancer Therapy by Wang, Junwei, Li, Hui, He, Guangchao, Chu, Zhaoxing, Peng, Kewen, Ge, Yiran, Zhu, Qihua, Xu, Yungen

“…Concomitant inhibition of PARP and PI3K pathways has been recognized as a promising strategy for cancer therapy, which may expand the clinical utility of PARP…”
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Regorafenib-loaded poly (lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma by Li, Xiang, He, Guangwei, Su, Feng, Chu, Zhaoxing, Xu, Leiming, Zhang, Yazhong, Zhou, Jianping, Ding, Yang

“…Transarterial chemoembolization (TACE) has been widely introduced to treat hepatocellular carcinoma (HCC) especially for unresectable patients for decades…”
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Semi-Mechanistic Modeling of HY-021068 Based on Irreversible Inhibition of Thromboxane Synthetase by Li, Ping, Huang, Jie, Geng, Donghao, Liu, Peihua, Chu, Zhaoxing, Zou, Jianjun, Yang, Guoping, Liu, Li

“…HY-021068 [4-(2-(1H-imidazol-1-yl) ethoxy)-3-methoxybenzoate], developed by Hefei Industrial Pharmaceutical Institute Co., Ltd. (Anhui, China), is a potential…”
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Phase I Trial of Pyragrel, a Novel Thromboxane Synthetase Inhibitor, to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers by Zou, Chan, Zuo, Xiaocong, Huang, Jie, Hua, Ye, Yang, Shuang, Yang, Xiaoyan, Guo, Can, Tan, Hongyi, Chen, Jun, Chu, Zhaoxing, Pei, Qi, Yang, Guoping

“…Background and Objective: Inhibition of thrombosis and platelet aggregation through a thromboxane synthetase inhibitor proved to be an effective and promising…”
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Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice by Huang, Ye, Han, Min, Shi, Qifeng, Li, Xuewang, Mo, Jiajia, Liu, Yan, Chu, Zhaoxing, Li, Weizu

“…Cerebral ischemia-reperfusion injury (CIRI) is a severe pathological condition that involves oxidative stress, inflammatory response, and neuronal damage…”
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Synthesis and biological evaluation of N-(benzene sulfonyl)acetamide derivatives as anti-inflammatory and analgesic agents with COX-2/5-LOX/TRPV1 multifunctional inhibitory activity by Chen, Wenli, Xu, Qinlong, Ma, Xiaodong, Mo, Jiajia, Lin, Gaofeng, He, Guangwei, Chu, Zhaoxing, Li, Jiaming

“…[Display omitted] •A series of novel N- (benzene sulfonyl) acetamide derivatives were designed and synthesized.•9a and 9b showed significant suppressive…”
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Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy by He, Xin, He, Guangchao, Chu, Zhaoxing, Wu, Huanhuan, Wang, Junjie, Ge, Yiran, Shen, Hui, Zhang, Shan, Shan, Jinxi, Peng, Kewen, Wei, Zhifeng, Zou, Yi, Xu, Yungen, Zhu, Qihua

“…Indoleamine 2,3-dioxygenase-1 (IDO1) plays an important role in tumor immune escape. However, unsatisfactory clinical efficacies of selective IDO1 inhibitors…”
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Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway by Mo, Jiajia, Zhou, Peng, Chu, Zhaoxing, Zhao, Yan, Wang, Xiang

“…Objective. To investigate the protective effect and mechanism of liquiritin (LIQ) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II). Methods…”
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Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 Ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method by Shao, Li, Mo, Jiajia, Xu, Qinlong, He, Guangwei, Xing, Chunyu, Chu, Zhaoxing

“…1. HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in…”
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Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents by Xu, Qinlong, Hu, Mengqi, Li, Jiaming, Ma, Xiaodong, Chu, Zhaoxing, Zhu, Qihua, Zhang, Yanchun, Zhu, Panhu, Huang, Yuanzheng, He, Guangwei

“…In this work, a novel structural series of brain-penetrant GluN2B NMDAR antagonists were designed, synthesized and biologically evaluated as anti-stroke…”
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Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain-Penetrant and In Vivo Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment by Lin, Gaofeng, Xu, Qinlong, Li, Jiaming, Chu, Zhaoxing, Ma, Xiaodong, Zhu, Qihua, Zhao, Yan, Mo, Jiajia, Ye, Wenfeng, Shao, Li, Fang, Tao, He, Minghan, Yue, Shaoyun, Dai, Mingqi

“…A series of structurally novel GluN2B NMDAR antagonists were designed, synthesized, and biologically evaluated as anti-stroke therapeutics by optimizing the…”
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Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis by Chu, Zhaoxing, Xu, Qinlong, Zhu, Qihua, Ma, Xiaodong, Mo, Jiajia, Lin, Gaofeng, Zhao, Yan, Gu, Yuanfeng, Bian, Lincui, Shao, Li, Guo, Jing, Ye, Wenfeng, Li, Jiaming, He, Guangwei, Xu, Yungen

“…In this work, a series of structurally novel benzoxaborole derivatives were designed, synthesized and biologically evaluated as PDE4 inhibitors for battling…”
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Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis by He, Guangchao, Wan, Sheng, Wu, Yunze, Chu, Zhaoxing, Shen, Hui, Zhang, Shan, Chen, Linya, Bao, Zijing, Gu, Shuhui, Huang, Junzhang, Huang, Lei, Gong, Guoqing, Zou, Yi, Zhu, Qihua, Xu, Yungen

“…Indoleamine 2,3-dioxygenase 2 (IDO2), a closely related homologue of well-studied immunomodulatory enzyme IDO1, has been identified as a pathogenic mediator of…”
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Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases by Chu, Zhaoxing, Cen, Lifang, Xu, Qinlong, Lin, Gaofeng, Mo, Jiajia, Shao, Li, Zhao, Yan, Li, Jiaming, Ye, Wenfeng, Fang, Tao, Ren, Weijie, Zhu, Qihua, He, Guangwei, Xu, Yungen

“…Desloratadine, a second-generation histamine H1 receptor antagonist, has established itself as a first-line drug for the treatment of allergic diseases…”
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LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study by Wu, Jingying, Zheng, Liang, Zhang, Qian, Zhang, Qin, Qin, Huiling, Zhou, Renpeng, Chu, Zhaoxing, He, Guangwei, Wang, Ling, Hu, Wei

“…HY072808 is a novel phosphodiesterase 4 inhibitor currently under clinical development to treat atopic dermatitis. The first step is to address the…”
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Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H1 antagonize activities by Li, Feng, Xu, Qinlong, Zhu, Qihua, Chu, Zhaoxing, Lin, Gaofeng, Mo, Jiajia, Zhao, Yan, Li, Jiaming, He, Guangwei, Xu, Yungen

“…To improve the anti-inflammatory activity of desloratadine, we designed and synthesized a series of novel desloratadine derivatives. All compounds were…”
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In vitro and Ex vivo Antioxidant Activity and Sustained Release Properties of Sinomenine-Loaded Liposomes-in-Hydrogel Biomaterials Simulating Cells-in-Extracellular Matrix by Yang, Xinying, Xia, Hongmei, Li, Yufan, Cheng, Yongfeng, Wang, Yu, Xia, Ying, Yue, Yan, Cheng, Xiaoman, Chu, Zhaoxing

“…Sinomenine (SIN), a natural product, has been used to treat rheumatoid arthritis (RA) in China for thousands of years. SIN has been developed for the treatment…”
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Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors by Zhu, Qihua, Wang, Xuyan, Chu, Zhaoxing, He, Guangwei, Dong, Guangping, Xu, Yungen

“…A series of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP inhibitors is described. A series of novel cyclic amine-substituted…”
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Profiling and Preparation of Metabolites from Pyragrel in Human Urine by Online Solid-Phase Extraction Coupled with High Performance Liquid Chromatography Tandem Mass Spectrometry Followed by a Macroporous Resin-Based Purification Approach by Zhao, Xin, Jiang, Jingjing, Yang, Guang, Huang, Jie, Yang, Guoping, He, Guangwei, Chu, Zhaoxing, Hang, Taijun, Fan, Guorong

“…Pyragrel, a new anticoagulant drug, is derived from the molecular combination of ligustrazine and ferulic acid. Pyragrel showed significant inhibitory activity…”
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