Search Results - "Chu, Xia"

The role of TGF-β/SMAD4 signaling in cancer by Zhao, Ming, Mishra, Lopa, Deng, Chu-Xia

“…Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis,…”
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Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation by Guo, Sen, Deng, Chu-Xia

“…The cellular environment where tumor cells reside is called the tumor microenvironment (TME), which consists of borders, blood vessels, lymph vessels,…”
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Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers by Huang, Tao, Deng, Chu-Xia

“…Cancer related exosomes are nano-size membrane vesicles that play important roles in tumor microenvironment. Emerging evidence indicates that exosomes can load…”
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The global battle against SARS-CoV-2 and COVID-19 by Deng, Chu-Xia

“…COVID-19 patients exhibit flu-like symptoms, such as persistent coughing, fever, shortness of breath, and difficulty breathing, which are similar to the Severe…”
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Recent progress in the biology and physiology of sirtuins by Finkel, Toren, Mostoslavsky, Raul, Deng, Chu-Xia

“…The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been…”
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SRC-3, a Steroid Receptor Coactivator: Implication in Cancer by Li, Licen, Deng, Chu-Xia, Chen, Qiang

“…Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the…”
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One step synthesis of efficient red emissive carbon dots and their bovine serum albumin composites with enhanced multi-photon fluorescence for in vivo bioimaging by Zhang, Huiqi, Wang, Gang, Zhang, Zhiming, Lei, Josh Haipeng, Liu, Tzu-Ming, Xing, Guichuan, Deng, Chu-Xia, Tang, Zikang, Qu, Songnan

“…Efficient red emissive carbon dots (CDs) in aqueous solutions are very scarce for high performance bioimaging applications. In this work, we report a one-step…”
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Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance by Zhang, Aiping, Miao, Kai, Sun, Heng, Deng, Chu-Xia

“…Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance,…”
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SIRT1, is it a tumor promoter or tumor suppressor? by Deng, Chu-Xia

“…SIRT1 has been considered as a tumor promoter because of its increased expression in some types of cancers and its role in inactivating proteins that are…”
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Biomineralized Metal–Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins by Chen, Ting-Ting, Yi, Jin-Tao, Zhao, Yan-Yan, Chu, Xia

“…Efficient delivery and endo-lysosomal release of active proteins in living cells remain a challenge in protein-based theranostics. We report a novel protein…”
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Oxygen‐Enriched Metal‐Phenolic X‐Ray Nanoprocessor for Cancer Radio‐Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy by Sang, Wei, Xie, Lisi, Wang, Guohao, Li, Jie, Zhang, Zhan, Li, Bei, Guo, Sen, Deng, Chu‐Xia, Dai, Yunlu

“…Radiotherapy (RT) based on DNA damage and reactive oxygen species (ROS) generation has been clinically validated in various types of cancer. However, high…”
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Emerging roles of SIRT1 in fatty liver diseases by Ding, Ren-Bo, Bao, Jiaolin, Deng, Chu-Xia

“…Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol consumption and/or other metabolic disorder causes, lead to…”
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A Dual-Emission Fluorescent Nanocomplex of Gold-Cluster-Decorated Silica Particles for Live Cell Imaging of Highly Reactive Oxygen Species by Chen, Tingting, Hu, Yihui, Cen, Yao, Chu, Xia, Lu, Yi

“…A novel nanocomplex displaying single-excitation and dual-emission fluorescent properties has been developed through a crown-like assembly of dye-encapsulated…”
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Toward Strong Near‐Infrared Absorption/Emission from Carbon Dots in Aqueous Media through Solvothermal Fusion of Large Conjugated Perylene Derivatives with Post‐Surface Engineering by Liu, Yupeng, Lei, Josh Haipeng, Wang, Gang, Zhang, Zhiming, Wu, Jun, Zhang, Bohan, Zhang, Huiqi, Liu, Enshan, Wang, Liming, Liu, Tzu‐Ming, Xing, Guichuan, Ouyang, Defang, Deng, Chu‐Xia, Tang, Zikang, Qu, Songnan

“…Carbon dots (CDs) have attracted significant interest as one of the most emerging photoluminescence (PL) nanomaterials. However, the realization of CDs with…”
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Characterization of potential driver mutations involved in human breast cancer by computational approaches by Rajendran, Barani Kumar, Deng, Chu-Xia

“…Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of…”
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Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype by Shao, Fangyuan, Sun, Heng, Deng, Chu-Xia

“…Triple-negative breast cancer (TNBC) is an aggressive subgroup of human breast cancer, which is characterized as estrogen receptor (ER) negative, progesterone…”
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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation by Miao, Kai, Lei, Josh Haipeng, Valecha, Monica Vishnu, Zhang, Aiping, Xu, Jun, Wang, Lijian, Lyu, Xueying, Chen, Si, Miao, Zhengqiang, Zhang, Xin, Su, Sek Man, Shao, Fangyuan, Rajendran, Barani Kumar, Bao, Jiaolin, Zeng, Jianming, Sun, Heng, Chen, Ping, Tan, Kaeling, Chen, Qiang, Wong, Koon Ho, Xu, Xiaoling, Deng, Chu-Xia

“…BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to…”
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Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics by Ding, Ren-Bo, Chen, Ping, Rajendran, Barani Kumar, Lyu, Xueying, Wang, Haitao, Bao, Jiaolin, Zeng, Jianming, Hao, Wenhui, Sun, Heng, Wong, Ada Hang-Heng, Valecha, Monica Vishnu, Yang, Eun Ju, Su, Sek Man, Choi, Tak Kan, Liu, Shuiming, Chan, Kin Iong, Yang, Ling-Lin, Wu, Jingbo, Miao, Kai, Chen, Qiang, Shim, Joong Sup, Xu, Xiaoling, Deng, Chu-Xia

“…Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer type with high morbidity in Southeast Asia, however the pathogenic mechanism of this disease…”
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Photocatalytic Pt(IV)‐Coordinated Carbon Dots for Precision Tumor Therapy by Guo, Dongbo, Lei, Josh Haipeng, Rong, Dade, Zhang, Tesen, Zhang, Bohan, Tang, Zikang, Shen, Han‐Ming, Deng, Chu‐Xia, Qu, Songnan

“…Rapid, efficient, and precise cancer therapy is highly desired. Here, this work reports solvothermally synthesized photoactivatable Pt(IV)‐coordinated carbon…”
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Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance by Wang, Rui-Hong, Kim, Hyun-Seok, Xiao, Cuiying, Xu, Xiaoling, Gavrilova, Oksana, Deng, Chu-Xia

“…Insulin resistance is a major risk factor for type 2 diabetes mellitus. The protein encoded by the sirtuin 1 (Sirt1) gene, which is a mouse homolog of yeast…”
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