Search Results - "Chu, Timothy H."

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells by Khairallah, Camille, Chu, Timothy H, Sheridan, Brian S

“…Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to…”
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PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice by Kim, Woosook, Chu, Timothy H., Nienhüser, Henrik, Jiang, Zhengyu, Del Portillo, Armando, Remotti, Helen E., White, Ruth A., Hayakawa, Yoku, Tomita, Hiroyuki, Fox, James G., Drake, Charles G., Wang, Timothy C.

“…Immune checkpoint inhibitors have limited efficacy in many tumors. We investigated mechanisms of tumor resistance to inhibitors of programmed cell death–1…”
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Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation by Qiu, Zhijuan, Khairallah, Camille, Chu, Timothy H, Imperato, Jessica N, Lei, Xinyuan, Romanov, Galina, Atakilit, Amha, Puddington, Lynn, Sheridan, Brian S

“…CD8 tissue-resident memory T (TRM) cells provide frontline protection at barrier tissues; however, mechanisms regulating TRM cell development are not…”
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γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans by Chu, Timothy H, Khairallah, Camille, Shieh, Jason, Cho, Rhea, Qiu, Zhijuan, Zhang, Yue, Eskiocak, Onur, Thanassi, David G, Kaplan, Mark H, Beyaz, Semir, Yang, Vincent W, Bliska, James B, Sheridan, Brian S

“…Yersinia pseudotuberculosis is a foodborne pathogen that subverts immune function by translocation of Yersinia outer protein (Yop) effectors into host cells…”
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TGF-β: Many Paths to CD103 + CD8 T Cell Residency by Qiu, Zhijuan, Chu, Timothy H, Sheridan, Brian S

“…CD8 tissue-resident memory T (T ) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against…”
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Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans by Chu, Timothy H, Khairallah, Camille, Shieh, Jason, Cho, Rhea, Qiu, Zhijuan, Zhang, Yue, Eskiocak, Onur, Thanassi, David G, Kaplan, Mark H, Beyaz, Semir, Yang, Vincent W, Bliska, James B, Sheridan, Brian S

“…[This corrects the article DOI: 10.1371/journal.ppat.1010103.]…”
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The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice by Khairallah, Camille, Chu, Timothy H, Qiu, Zhijuan, Imperato, Jessica N, Yang, Daniella, Sheridan, Brian S

“…It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade…”
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Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer by Chen, Xiaowei, Takemoto, Yoshihiro, Deng, Huan, Middelhoff, Moritz, Friedman, Richard A., Chu, Timothy H., Churchill, Michael J., Ma, Yan, Nagar, Karan K., Tailor, Yagnesh H., Mukherjee, Siddhartha, Wang, Timothy C.

“…The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus…”
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KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model by Shieh, Jason, Chu, Timothy H, Liu, Yang, Kim, Julie, Ruiz de Sabando, Ainara, Kobayashi, Soma, Zee, Sui Y, Sheridan, Brian S, Bialkowska, Agnieszka B, Yang, Vincent W

“…Inflammatory bowel disease (IBD) is a chronic illness characterized by dysregulated immune cascades in the intestines, in which the Th17 immune response plays…”
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Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling by Normile, Tyler G., Chu, Timothy H., Sheridan, Brian S., Del Poeta, Maurizio

“…We previously reported that administration of Cryptococcus neoformans Δ sgl1 mutant vaccine, accumulating sterylglucosides (SGs) and having normal capsule…”
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Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop by Chen, Xiaowei, Deng, Huan, Churchill, Michael J., Luchsinger, Larry L., Du, Xing, Chu, Timothy H., Friedman, Richard A., Middelhoff, Moritz, Ding, Hongxu, Tailor, Yagnesh H., Wang, Alexander L.E., Liu, Haibo, Niu, Zhengchuan, Wang, Hongshan, Jiang, Zhengyu, Renders, Simon, Ho, Siu-Hong, Shah, Spandan V., Tishchenko, Pavel, Chang, Wenju, Swayne, Theresa C., Munteanu, Laura, Califano, Andrea, Takahashi, Ryota, Nagar, Karan K., Renz, Bernhard W., Worthley, Daniel L., Westphalen, C. Benedikt, Hayakawa, Yoku, Asfaha, Samuel, Borot, Florence, Lin, Chyuan-Sheng, Snoeck, Hans-Willem, Mukherjee, Siddhartha, Wang, Timothy C.

“…Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone…”
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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis by Jiang, Zhengyu, Wu, Feijing, Laise, Pasquale, Takayuki, Tanaka, Na, Fu, Kim, Woosook, Kobayashi, Hiroki, Chang, Wenju, Takahashi, Ryota, Valenti, Giovanni, Sunagawa, Masaki, White, Ruth A, Macchini, Marina, Renz, Bernhard W, Middelhoff, Moritz, Hayakawa, Yoku, Dubeykovskaya, Zinaida A, Tan, Xiangtian, Chu, Timothy H, Nagar, Karan, Tailor, Yagnesh, Belin, Bryana R, Anand, Akanksha, Asfaha, Samuel, Finlayson, Michael O, Iuga, Alina C, Califano, Andrea, Wang, Timothy C

“…While adult pancreatic stem cells are thought not to exist, it is now appreciated that the acinar compartment harbors progenitors, including tissue-repairing…”
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The use of foodborne infection to evaluate bacterial pathogenesis and host response by Chu, Timothy H, Qiu, Zhijuan, Sheridan, Brian S

“…Foodborne bacterial infections are a major cause of gastrointestinal illness. Murine models have been widely used to interrogate bacterial pathogenesis and…”
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A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells by Khairallah, Camille, Bettke, Julie A., Gorbatsevych, Oleksandr, Qiu, Zhijuan, Zhang, Yue, Cho, Kyungjin, Kim, Kwang Soon, Chu, Timothy H., Imperato, Jessica N., Hatano, Shinya, Romanov, Galina, Yoshikai, Yasunobo, Puddington, Lynn, Surh, Charles D., Bliska, James B., van der Velden, Adrianus W. M., Sheridan, Brian S.

“…Although murine γδ T cells are largely considered innate immune cells, they have recently been reported to form long-lived memory populations. Much remains…”
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Abstract LB-272: Histidine decarboxylase (Hdc)-expressing myeloid cells support Foxp3+ Treg cells and promote colorectal cancer progression by Chen, Xiaowei, Takemoto, Yoshihiro, Nagar, Karan K., Chu, Timothy H., Jiang, Zhengyu, Chang, Wenju, Friedman, Richard A., Tailor, Yagnesh H., Worthley, Daniel L., Wang, Timothy C.

“…Abstract The tumor microenvironment contains a diverse population of myeloid cells that are recruited from bone marrow and converted to immunosuppressive…”
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Sa1363 Newly Synthesized Selective Beta-2 Blockers Reveal Stress Mediated Acceleration of Pancreatic Carcinogenesis by Jiang, Zhengyu, Renz, Bernhard W, Deng, Shi-xian, Xu, Xiaoming, Macchini, Marina, Chen, Xiaowei, Chang, Wenju, Chu, Timothy H, Nagar, Karan K, Tailor, Yagnesh, Landry, Donald W, Wang, Timothy C

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Su1865 Bacterial Infection Contributes to Inflammation-Associated Cancer Progression via Increased Trafficking of HDC-Expressing Neutrophils by Chen, Xiaowei, Nagar, Karan K, Chu, Timothy H, Jiang, Zhengyu, Chang, Wenju, Friedman, Richard A, Ge, Zhongming, Sakitani, Kosuke, Hayakawa, Yoku, Tailor, Yagnesh, Wang, Edwin, Worthley, Daniel L, Churchill, Michael J, Mukherjee, Siddhartha, Erdman, Susan, Fox, James G, Wang, Timothy C

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803 MIST1 Positive Stem Cells in the Antrum Serve As a Cell-of-Origin for Gastric Cancer With APC Loss by Sakitani, Kosuke, Hayakawa, Yoku, Kim, Woosook, Urbanska, Aleksandra, Chang, Wenju, Middelhoff, Moritz, Dubeykovskaya, Zinaida A, Jiang, Zhengyu, Tanaka, Takayuki, Chen, Xiaowei, Tailor, Yagnesh, Nagar, Karan K, Chu, Timothy H, Fox, James G, Wang, Timothy C

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359 MICE WITH INTESTINE-SPECIFIC DELETION OF KRÜPPEL-LIKE FACTOR 5 EXHIBIT A TH17 IMMUNERESPONSE WITH ABERRANT CELLULAR LOCALIZATION OF PHOSPHORYLATED STAT3 IN THE INTESTINAL EPITHELIUM by Shieh, Jason, Liu, Yang, Chu, Timothy H., de Sabando, Ainara Ruiz, Sheridan, Brian, Bialkowska, Agnieszka B., Yang, Vincent W.

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Mesenteric lymph node priming licenses intestinal CD103+ CD8 tissue-resident memory T cell development by Qiu, Zhijuan, Khairallah, Camille, Chu, Timothy H., Imperato, Jessica N., Romanov, Galina, Puddington, Lynn, Sheridan, Brian S.

“…Abstract CD8 tissue-resident memory T (TRM) cells provide front-line protective immunity at barrier tissues; however, mechanisms regulating their development…”
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