Search Results - "Chu, S Haihua"

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia by Mar, Brenton G., Chu, S. Haihua, Kahn, Josephine D., Krivtsov, Andrei V., Koche, Richard, Castellano, Cecilia A., Kotlier, Jacob L., Zon, Rebecca L., McConkey, Marie E., Chabon, Jonathan, Chappell, Ryan, Grauman, Peter V., Hsieh, James J., Armstrong, Scott A., Ebert, Benjamin L.

“…Mutations in SETD2, encoding the histone 3 lysine 36 trimethyltransferase, are enriched in relapsed acute lymphoblastic leukemia and MLL-rearranged acute…”
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miR-99 regulates normal and malignant hematopoietic stem cell self-renewal by Khalaj, Mona, Woolthuis, Carolien M, Hu, Wenhuo, Durham, Benjamin H, Chu, S Haihua, Qamar, Sarah, Armstrong, Scott A, Park, Christopher Y

“…The microRNA-99 (miR-99) family comprises a group of broadly conserved microRNAs that are highly expressed in hematopoietic stem cells (HSCs) and acute myeloid…”
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FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm by Chu, S. Haihua, Heiser, Diane, Li, Li, Kaplan, Ian, Collector, Michael, Huso, David, Sharkis, Saul J., Civin, Curt, Small, Don

“…Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and…”
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MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C by Zhu, Nan, Chen, Mo, Eng, Rowena, DeJong, Joshua, Sinha, Amit U, Rahnamay, Noushin F, Koche, Richard, Al-Shahrour, Fatima, Minehart, Janna C, Chen, Chun-Wei, Deshpande, Aniruddha J, Xu, Haiming, Chu, S Haihua, Ebert, Benjamin L, Roeder, Robert G, Armstrong, Scott A

“…Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are…”
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Mechanisms of resistance to FLT3 inhibitors by Chu, S. Haihua, Small, Donald

“…Abstract The success of the small molecule tyrosine kinase receptor inhibitor (TKI) imatinib mesylate (Gleevec) in the treatment of chronic myeloid leukemia…”
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Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras by Chu, S. Haihua, Song, Evelyn J., Chabon, Jonathan R., Minehart, Janna, Matovina, Chloe N., Makofske, Jessica L., Frank, Elizabeth S., Ross, Kenneth, Koche, Richard P., Feng, Zhaohui, Xu, Haiming, Krivtsov, Andrei, Nussenzweig, Andre, Armstrong, Scott A.

“…Infant B-cell acute lymphoblastic leukemias (B-ALLs) that harbor MLL-AF4 rearrangements are associated with a poor prognosis. One important obstacle to…”
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Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development by Chu, S. Haihua, Chabon, Jonathan R., Matovina, Chloe N., Minehart, Janna C., Chen, Bo-Ruei, Zhang, Jian, Kumar, Vipul, Xiong, Yijun, Callen, Elsa, Hung, Putzer J., Feng, Zhaohui, Koche, Richard P., Liu, X. Shirley, Chaudhuri, Jayanta, Nussenzweig, Andre, Sleckman, Barry P., Armstrong, Scott A.

“…Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable…”
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Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis by Hérault, Aurélie, Binnewies, Mikhail, Leong, Stephanie, Calero-Nieto, Fernando J., Zhang, Si Yi, Kang, Yoon-A, Wang, Xiaonan, Pietras, Eric M., Chu, S. Haihua, Barry-Holson, Keegan, Armstrong, Scott, Göttgens, Berthold, Passegué, Emmanuelle

“…Although many aspects of blood production are well understood, the spatial organization of myeloid differentiation in the bone marrow remains unknown. Here we…”
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NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis by Xu, Haiming, Valerio, Daria G., Eisold, Meghan E., Sinha, Amit, Koche, Richard P., Hu, Wenhuo, Chen, Chun-Wei, Chu, S. Haihua, Brien, Gerard L., Park, Christopher Y., Hsieh, James J., Ernst, Patricia, Armstrong, Scott A.

“…The nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies. Here, we demonstrate that NUP98 fusion proteins,…”
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Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition by Zhu, Ruiqi, Shirley, Courtney M., Chu, S. Haihua, Li, Li, Nguyen, Bao H., Seo, Jaesung, Wu, Min, Seale, Tessa, Duffield, Amy S., Staudt, Louis M., Levis, Mark, Hu, Yu, Small, Donald

“…Internal tandem duplication mutations of FLT3 (FLT3/ITD) confer poor prognosis in AML. FLT3 tyrosine kinase inhibitors (TKIs) alone have limited and transient…”
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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia by Cremer, Anjali, Ellegast, Jana M, Alexe, Gabriela, Frank, Elizabeth S, Ross, Linda, Chu, S Haihua, Pikman, Yana, Robichaud, Amanda, Goodale, Amy, Häupl, Björn, Mohr, Sebastian, Rao, Arati V, Walker, Alison R, Blachly, James S, Piccioni, Federica, Armstrong, Scott A, Byrd, John C, Oellerich, Thomas, Stegmaier, Kimberly

“…Spleen tyrosine kinase (SYK) is a nonmutated therapeutic target in acute myeloid leukemia (AML). Attempts to exploit SYK therapeutically in AML have shown…”
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Stem cells: Dual response to Ras mutation by Chu, S Haihua, Armstrong, Scott A

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Dual response to Ras mutation by Chu, S. Haihua, Armstrong, Scott A.

“…Proliferation-driving mutations in haematopoietic stem cells often result in the loss of stem-cell properties. But at least one common oncogenic mutation seems…”
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Polyhydroxybutyrate-enhanced transformation of log-phase Escherichia coli by Addison, Charles J, Chu, S Haihua, Reusch, Rosetta N

“…Transformation of Escherichia coli plays an important role in recombinant DNA technology. Most current transformation protocols require that the cells be…”
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Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant through Engineered Stem Cell Antibody Paired Evasion (ESCAPE) by Mondal, Nandini, Harmon, Alexander, Budak, Elizabeth, Zhang, Kathy, Wong, Jeffrey, Menon, Archita Venugopal, Wolin, Adam, White, Moriah, Musenge, Faith, Camblin, Adam, Coisman, Brent, Lucini, Corrina, Bai, Tao, Qiao, Kangjian, Austin, Wayne, DeLelys, Michelle, Kromer, Hugh, Hardy, Lisa, Law, Megan, Manoukian, Raffi, Goldsmith, Rachel, Fallon, Kiera, Patel, Mudra, Cozier, Antoinette, Lazzara, Colin, Decker, Jeremy, Jenkins, Rebecca, Bohnuud, Tanggis, Feliciano, Patricia, Lee, Seung-Joo, Kopesky, Paul, Smith, Sarah, McDonagh, Charlotte, Gaudelli, Nicole, Chu, S. Haihua, Hartigan, Adam, Shankar, Gopi, Ciaramella, Giuseppe

“…While ex vivo gene editing of CD34 + hematopoietic stem and progenitor cells (HSPCs) offers potentially curative therapies for patients with serious diseases,…”
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Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies by Mondal, Nandini, Harmon, Alexander, Budak, Elizabeth, Zhang, Kathy, Wong, Jeffrey, Rinaldi, Conrad, Olins, Jenny, Hoar, Kara, Menon, Archita Venugopal, White, Moriah, Musenge, Faith, Camblin, Adam, Wolin, Adam, Coisman, Brent, Bai, Tao, Qiao, Kangjian, Patel, Mudra, Decker, Jeremy, Gantzer, Bob, Leete, Thomas, Yu, Yi, Bohnuud, Tanggis, Lee, Seung-Joo, Smith, Sarah, McDonagh, Charlotte F, Gaudelli, Nicole M., Chu, S. Haihua, Hartigan, Adam J., Ciaramella, Giuseppe

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Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease by Chu, S. Haihua, Budak, Elizabeth, Mondal, Nandini, Zhang, Kathy, Harmon, Alexander, Wong, Jeffrey, Lam, Dieter, Lucini, Corrina, Coisman, Brent, Qiao, Kangjian, Bai, Tao, Decker, Jeremy, Gantzer, Bob, Lee, Kindo, Sen, Maya, Bohnuud, Tanggis, Barrera, Luis, Cafferty, Brian, Lee, Seung-Joo, Kopesky, Paul, Gaudelli, Nicole M., McDonagh, Charlotte F, Ciaramella, Giuseppe, Hartigan, Adam J.

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Adenine Base Editing of the Sickle Allele in CD34+ Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S by Chu, S. Haihua, Lam, Daisy, Packer, Michael S., Olins, Jennifer, Liquori, Alexander, Marshall, Jeffrey, Lee, Calvin, Yan, Bo, Decker, Jeremy, Gantzer, Bob, Haskett, Scott J., Bohnuud, Tanggis, Born, David, Barrera, Luis, Slaymaker, Ian, Gaudelli, Nicole M., Hartigan, Adam J., Ciaramella, Giuseppe

“…While there are several small molecule, gene therapy, and gene editing approaches for treating sickle cell disease (SCD), these strategies do not result in the…”
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Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function by Chu, S. Haihua, Ortega, Manuel, Feliciano, Paty, Winton, Valerie, Xu, Chavonna, Haupt, Daniel, McDonald, Teresa, Martinez, Salette, Liquori, Alexander, Marshall, Jeffrey, Lam, Daisy, Olins, Jenny, Rinaldi, Conrad, Rehberger, Kyle, Lazarra, Colin, Decker, Jeremy, Gantzer, Bob, Bohnuud, Tanggis, Born, David, Barrera, Luis, Yan, Bo, Slaymaker, Ian, Packer, Michael S., Smith, Sarah, Zambonelli, Carlo, Lee, Matt, Gaudelli, Nicole M., Hartigan, Adam J., Ciaramella, Giuseppe

“…Conversion of the pathogenic sickle allele to a naturally occurring, non-pathogenic hemoglobin variant, Hb G-Makassar, represents a long-term and durable…”
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Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations by Song, Evelyn J, Chu, S. Haihua, Minehart, Janna, Chabon, Jonathan, Koche, Richard, Krivtsov, Andrei, Armstrong, Scott A.

“…Childhood B-cell acute lymphoblastic leukemia (B-ALL) that harbor a translocation of the MLL1 and AF4 genes are considered high-risk with poor prognosis…”
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