Search Results - "Chu, Phillip Y."

Improved translation of stability for conjugated antibodies using an in vitro whole blood assay by Fourie-O'Donohue, Aimee, Chu, Phillip Y, Dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C, Sawyer, William S, Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H, Sadowsky, Jack, Dragovich, Peter S, Liu, Yichin, Kozak, Katherine R

“…For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several…”
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High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry by Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.

“…Toward the goal of increasing the throughput of high-resolution mass characterization of intact antibodies, we developed a RapidFire–mass spectrometry (MS)…”
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Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics by Chu, Phillip Y., Wang, Hui, Ross, Emily, Stephens, Nicole, Zhang, Hui-Min, Andersen, Nisana, Chan, Wayman, Shivva, Vittal, Crowell, Susan R., Spiess, Christoph, Holder, Patrick G., Agard, Nicholas J., Ji, Chengjie, Chen, John, Sreedhara, Alavattam, Wang, Jianyong, Wu, Cong, Liu, Yichin, Tran, John C.

“…Biotransformation leading to single residue modifications (e.g., deamidation, oxidation) can contribute to decreased efficacy/potency, poor pharmacokinetics,…”
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Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood by Li, Ke Sherry, Chu, Phillip Y., Fourie-O’Donohue, Aimee, Srikumar, Neha, Kozak, Katherine R., Liu, Yichin, Tran, John C.

“…Antibody-drug conjugates (ADCs) present unique challenges for ligand-binding assays primarily due to the dynamic changes of the drug-to-antibody ratio (DAR)…”
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Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema by Agard, Nicholas J., Zhang, Gu, Ridgeway, John, Dicara, Danielle M., Chu, Phillip Y., Ohri, Rachana, Sanowar, Sarah, Vernes, Jean-Michel, Chi, Hannah, Zhang, Jiameng, Holz, Emily, Paluch, Maciej, He, Guannan, Benson, Yingjia, Zhang, Jianhuan, Chan, Pamela, Tang, Nga, Javale, Prachi, Wilson, Blair, Barrett, Kathy, Rowntree, Rebecca K., Hang, Julie, Meng, Y. Gloria, Hass, Phil, Fuh, Germaine, Piskol, Robert, Bantseev, Vladimir, Loyet, Kelly M., Tran, John C., Wu, Cong, Indjeian, Vahan B., Shivva, Vittal, Yan, Minhong

“…PurposeDiabetic macular edema (DME) is the leading cause of vision loss and blindness among working-age adults. Although current intravitreal anti-vascular…”
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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay by Fourie-O'Donohue, Aimee, Chu, Phillip Y., dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C., Sawyer, William S., Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H., Sadowsky, Jack, Dragovich, Peter S., Liu, Yichin, Kozak, Katherine R.

“…For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several…”
Get full text